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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
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Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


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isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 6 122,553,809 122,564,180 RGD:2290270
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 11 80,089,379 80,135,797 RGD:2290270
G Batf basic leucine zipper transcription factor, ATF-like JBrowse link 12 85,686,720 85,709,087 RGD:2290270
G Cd40lg CD40 ligand JBrowse link X 57,212,143 57,224,042 RGD:2290270
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 JBrowse link 7 19,344,067 19,356,524 RGD:2290270
G Exo1 exonuclease 1 JBrowse link 1 175,880,768 175,911,396 RGD:2290270
G Exosc3 exosome component 3 JBrowse link 4 45,316,613 45,320,616 RGD:2290270
G Exosc6 exosome component 6 JBrowse link 8 111,056,339 111,057,664 RGD:2290270
G Icosl icos ligand JBrowse link 10 78,069,368 78,079,525 RGD:2290270
G Lig4 ligase IV, DNA, ATP-dependent JBrowse link 8 9,970,020 9,977,696 RGD:2290270
G Mlh1 mutL homolog 1 JBrowse link 9 111,228,228 111,271,786 RGD:2290270
G Msh2 mutS homolog 2 JBrowse link 17 87,672,532 87,723,713 RGD:2290270
G Msh6 mutS homolog 6 JBrowse link 17 87,975,050 87,990,892 RGD:2290270
G Nbn nibrin JBrowse link 4 15,957,587 15,992,589 RGD:2290270
G Rnf168 ring finger protein 168 JBrowse link 16 32,277,461 32,301,442 RGD:2290270
G Rnf8 ring finger protein 8 JBrowse link 17 29,614,789 29,641,664 RGD:2290270
G Swap70 SWA-70 protein JBrowse link 7 110,221,703 110,283,506 RGD:2290270
G Ung uracil DNA glycosylase JBrowse link 5 114,130,366 114,139,321 RGD:2290270
G Xrcc4 X-ray repair complementing defective repair in Chinese hamster cells 4 JBrowse link 13 89,848,914 90,089,608 RGD:2290270
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 chemokine (C-C motif) receptor 6 JBrowse link 17 8,236,041 8,258,519 RGD:2290270
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspd1 heat shock protein 1 (chaperonin) JBrowse link 1 55,077,833 55,088,243 RGD:2290270
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 9 106,470,322 106,476,949 RGD:2290270
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Thoc1 THO complex 1 JBrowse link 18 9,958,180 9,995,484 RGD:2290270
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 B cell leukemia/lymphoma 6 JBrowse link 16 23,965,050 23,988,866 RGD:2290270
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 38,418,907 38,465,197 RGD:2290270
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exosc3 exosome component 3 JBrowse link 4 45,316,613 45,320,616 RGD:2290270
G Exosc6 exosome component 6 JBrowse link 8 111,056,339 111,057,664 RGD:2290270
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific JBrowse link 6 87,913,907 87,936,619 RGD:2290270
G Kmt5b lysine methyltransferase 5B JBrowse link 19 3,767,362 3,818,303 RGD:2290270
G Kmt5c lysine methyltransferase 5C JBrowse link 7 4,740,092 4,747,514 RGD:2290270
G Mad2l2 MAD2 mitotic arrest deficient-like 2 JBrowse link 4 148,130,158 148,145,704 RGD:2290270
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 JBrowse link 5 27,740,080 27,791,672 RGD:2290270
G Rif1 replication timing regulatory factor 1 JBrowse link 2 52,072,815 52,126,769 RGD:2290270
G Shld1 shieldin complex subunit 1 JBrowse link 2 132,686,931 132,751,055 RGD:2290270
G Shld2 shieldin complex subunit 2 JBrowse link 14 34,236,948 34,310,651 RGD:2290270
G Tfrc transferrin receptor JBrowse link 16 32,608,896 32,632,794 RGD:2290270
G Trp53bp1 transformation related protein 53 binding protein 1 JBrowse link 2 121,194,835 121,296,354 RGD:2290270
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link 9 111,228,228 111,271,786 RGD:2290270
G Msh2 mutS homolog 2 JBrowse link 17 87,672,532 87,723,713 RGD:2290270
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link 5 33,820,676 33,897,966 RGD:2290270
G Pms2 PMS1 homolog2, mismatch repair system component JBrowse link 5 143,909,901 143,972,745 RGD:2290270
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:2290270
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 JBrowse link 11 69,682,577 69,685,554 RGD:2290270
G Tnfsfm13 tumor necrosis factor (ligand) superfamily, membrane-bound member 13 JBrowse link 11 69,682,577 69,696,098 RGD:2290270
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcf1 cardiotrophin-like cytokine factor 1 JBrowse link 19 4,214,238 4,223,505 RGD:2290270
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
G Stat6 signal transducer and activator of transcription 6 JBrowse link 10 127,642,955 127,660,987 RGD:2290270
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family, AAA domain containing 5 JBrowse link 11 80,089,379 80,135,797 RGD:2290270
G Cd28 CD28 antigen JBrowse link 1 60,746,388 60,773,359 RGD:2290270
G Cd40 CD40 antigen JBrowse link 2 165,055,614 165,071,654 RGD:2290270
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:2290270
G Il2 interleukin 2 JBrowse link 3 37,120,713 37,125,954 RGD:2290270
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
G Mlh1 mutL homolog 1 JBrowse link 9 111,228,228 111,271,786 RGD:2290270
G Msh2 mutS homolog 2 JBrowse link 17 87,672,532 87,723,713 RGD:2290270
G Pagr1a PAXIP1 associated glutamate rich protein 1A JBrowse link 7 127,015,051 127,017,352 RGD:2290270
G Paxip1 PAX interacting (with transcription-activation domain) protein 1 JBrowse link 5 27,740,080 27,791,672 RGD:2290270
G Pms2 PMS1 homolog2, mismatch repair system component JBrowse link 5 143,909,901 143,972,745 RGD:2290270
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 1 138,062,859 138,175,756 RGD:2290270
G Tbx21 T-box 21 JBrowse link 11 97,098,007 97,115,331 RGD:2290270
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link 6 87,628,425 87,672,237 RGD:2290270
G Mir181b-1 microRNA 181b-1 JBrowse link 1 137,966,639 137,966,718 RGD:2290270
G Mir181b-2 microRNA 181b-2 JBrowse link 2 38,853,830 38,853,918 RGD:2290270
G Supt6 SPT6, histone chaperone and transcription elongation factor JBrowse link 11 78,206,749 78,245,972 RGD:2290270
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:2290270
G Il27ra interleukin 27 receptor, alpha JBrowse link 8 84,030,286 84,042,600 RGD:2290270
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 38,418,907 38,465,197 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23162
    immune system process 2759
      leukocyte activation 1023
        lymphocyte activation 858
          lymphocyte activation involved in immune response 200
            B cell activation involved in immune response 84
              isotype switching 57
                isotype switching to IgA isotypes + 9
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 7
                isotype switching to IgG isotypes + 17
                negative regulation of isotype switching + 5
                positive regulation of isotype switching + 31
                regulation of isotype switching + 41
Path 2
Term Annotations click to browse term
  biological_process 23162
    metabolic process 10900
      cellular metabolic process 9695
        heterocycle metabolic process 5013
          nucleobase-containing compound metabolic process 4876
            nucleic acid metabolic process 4443
              DNA metabolic process 843
                DNA recombination 288
                  somatic cell DNA recombination 71
                    somatic diversification of immune receptors via germline recombination within a single locus 71
                      somatic recombination of immunoglobulin gene segments 62
                        somatic recombination of immunoglobulin genes involved in immune response 57
                          isotype switching 57
                            isotype switching to IgA isotypes + 9
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 7
                            isotype switching to IgG isotypes + 17
                            negative regulation of isotype switching + 5
                            positive regulation of isotype switching + 31
                            regulation of isotype switching + 41
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.