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ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
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Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


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isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 12 42,874,705 42,920,438 RGD:14298760
G CD40LG CD40 ligand JBrowse link X 111,778,666 111,788,901 RGD:14298760
G EXOSC3 exosome component 3 JBrowse link 1 238,536,341 238,541,756 RGD:14298760
G EXOSC6 exosome component 6 JBrowse link 6 13,295,591 13,296,942 RGD:14298760
G LIG4 DNA ligase 4 JBrowse link 11 75,537,027 75,547,711 RGD:14298760
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G MSH6 mutS homolog 6 JBrowse link 3 92,792,590 92,814,154 RGD:14298760
G NBN nibrin JBrowse link 4 46,787,664 46,854,331 RGD:14298760
G SWAP70 switching B cell complex subunit SWAP70 JBrowse link 2 49,721,120 49,805,262 RGD:14298760
G UNG uracil DNA glycosylase JBrowse link 14 41,746,498 41,757,841 RGD:14298760
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCR6 C-C motif chemokine receptor 6 JBrowse link 1 2,016,600 2,034,172 RGD:14298760
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HSPD1 heat shock protein family D (Hsp60) member 1 JBrowse link 15 101,360,355 101,373,498 RGD:14298760
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 13 34,075,807 34,084,384 RGD:14298760
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 13 125,377,247 125,401,328 RGD:14298760
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 1 238,536,341 238,541,756 RGD:14298760
G EXOSC6 exosome component 6 JBrowse link 6 13,295,591 13,296,942 RGD:14298760
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 13 71,732,311 71,752,296 RGD:14298760
G KMT5B lysine methyltransferase 5B JBrowse link 2 4,710,510 4,768,237 RGD:14298760
G KMT5C lysine methyltransferase 5C JBrowse link 6 59,517,058 59,524,551 RGD:14298760
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 6 71,773,680 71,779,192 RGD:14298760
G RIF1 replication timing regulatory factor 1 JBrowse link 15 769,518 832,036 RGD:14298760
G SHLD1 shieldin complex subunit 1 JBrowse link 17 14,610,723 14,706,082 RGD:14298760
G SHLD2 shieldin complex subunit 2 JBrowse link 14 88,005,599 88,121,155 RGD:14298760
G TFRC transferrin receptor JBrowse link 13 133,976,765 133,997,554 RGD:14298760
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 1 127,958,500 128,032,370 RGD:14298760
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 8 938,832 1,018,032 RGD:14298760
G TGFB1 transforming growth factor beta 1 JBrowse link 6 49,332,169 49,348,642 RGD:14298760
G TNFSF13 TNF superfamily member 13 JBrowse link 12 52,853,646 52,857,033 RGD:14298760
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4 interleukin 4 JBrowse link 2 134,986,817 134,994,365 RGD:14298760
G STAT6 signal transducer and activator of transcription 6 JBrowse link 5 22,406,356 22,422,412 RGD:14298760
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 12 42,874,705 42,920,438 RGD:14298760
G CD28 CD28 molecule JBrowse link 15 107,128,103 107,155,431 RGD:14298760
G CD40 CD40 molecule JBrowse link 17 48,286,116 48,298,188 RGD:14298760
G IL2 interleukin 2 JBrowse link 8 101,640,938 101,645,683 RGD:14298760
G IL4 interleukin 4 JBrowse link 2 134,986,817 134,994,365 RGD:14298760
G MLH1 mutL homolog 1 JBrowse link 13 21,791,276 21,877,789 RGD:14298760
G MSH2 mutS homolog 2 JBrowse link 3 93,082,958 93,163,556 RGD:14298760
G PAXIP1 PAX interacting protein 1 JBrowse link 18 3,066,853 3,111,239 RGD:14298760
G PTPRC protein tyrosine phosphatase receptor type C JBrowse link 10 21,482,984 21,601,627 RGD:14298760
G TBX21 T-box transcription factor 21 JBrowse link 12 23,996,415 24,009,353 RGD:14298760
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 3 73,752,115 73,831,158 RGD:14298760
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 12 44,916,716 44,940,732 RGD:14298760
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G IL27RA interleukin 27 receptor subunit alpha JBrowse link 2 65,127,278 65,149,665 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15166
    immune system process 1627
      leukocyte activation 575
        lymphocyte activation 481
          lymphocyte activation involved in immune response 137
            B cell activation involved in immune response 59
              isotype switching 40
                isotype switching to IgA isotypes + 6
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 5
                isotype switching to IgG isotypes + 14
                negative regulation of isotype switching + 4
                positive regulation of isotype switching + 25
                regulation of isotype switching + 32
Path 2
Term Annotations click to browse term
  biological_process 15166
    metabolic process 9321
      cellular metabolic process 8405
        heterocycle metabolic process 4325
          nucleobase-containing compound metabolic process 4222
            nucleic acid metabolic process 3865
              DNA metabolic process 659
                DNA recombination 229
                  somatic cell DNA recombination 53
                    somatic diversification of immune receptors via germline recombination within a single locus 53
                      somatic recombination of immunoglobulin gene segments 45
                        somatic recombination of immunoglobulin genes involved in immune response 40
                          isotype switching 40
                            isotype switching to IgA isotypes + 6
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 5
                            isotype switching to IgG isotypes + 14
                            negative regulation of isotype switching + 4
                            positive regulation of isotype switching + 25
                            regulation of isotype switching + 32
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.