Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:isotype switching
go back to main search page
Accession:GO:0045190 term browser browse the term
Definition:The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
Comment:Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
Synonyms:exact_synonym: class switch recombination;   class switching;   isotype switch recombination
 xref: Wikipedia:Immunoglobulin_class_switching


show annotations for term's descendants       view all columns           Sort by:
 
isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation induced cytidine deaminase JBrowse link NW_004936870 25,039 34,601 RGD:9068941
G Atad5 ATPase family AAA domain containing 5 JBrowse link NW_004936538 2,815,370 2,877,084 RGD:9068941
G Batf basic leucine zipper ATF-like transcription factor JBrowse link NW_004936488 4,607,716 4,631,237 RGD:9068941
G Cd40lg CD40 ligand JBrowse link NW_004936513 10,607,617 10,620,403 RGD:9068941
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link NW_004936706 1,854,938 1,867,521 RGD:9068941
G Exo1 exonuclease 1 JBrowse link NW_004936526 8,570,488 8,627,004 RGD:9068941
G Exosc3 exosome component 3 JBrowse link NW_004936524 5,580,855 5,586,170 RGD:9068941
G Exosc6 exosome component 6 JBrowse link NW_004936475 23,295,441 23,297,321 RGD:9068941
G Lig4 DNA ligase 4 JBrowse link NW_004936472 3,861,833 3,867,943 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004936473 26,556,636 26,600,830 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004936508 4,943,987 5,013,356 RGD:9068941
G Msh6 mutS homolog 6 JBrowse link NW_004936508 4,708,661 4,728,671 RGD:9068941
G Nbn nibrin JBrowse link NW_004936544 3,773,828 3,812,673 RGD:9068941
G Rnf168 ring finger protein 168 JBrowse link NW_004936784 1,073,236 1,094,575 RGD:9068941
G Rnf8 ring finger protein 8 JBrowse link NW_004936476 22,074,146 22,121,286 RGD:9068941
G Swap70 switching B cell complex subunit SWAP70 JBrowse link NW_004936528 8,441,839 8,511,374 RGD:9068941
G Ung uracil DNA glycosylase JBrowse link NW_004936769 911,296 922,770 RGD:9068941
isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr6 C-C motif chemokine receptor 6 JBrowse link NW_004936489 16,669,297 16,689,451 RGD:9068941
isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link NW_004936506 1,678,069 1,687,632 RGD:9068941
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp3 poly(ADP-ribose) polymerase family member 3 JBrowse link NW_004936529 3,291,282 3,297,581 RGD:9068941
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Thoc1 THO complex 1 JBrowse link NW_004936550 590,119 638,152 RGD:9068941
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 BCL6 transcription repressor JBrowse link NW_004936578 2,371,976 2,395,034 RGD:9068941
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link NW_004936504 12,053,470 12,103,346 RGD:9068941
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004936481 14,391,359 14,409,514 RGD:9068941
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exosc3 exosome component 3 JBrowse link NW_004936524 5,580,855 5,586,170 RGD:9068941
G Exosc6 exosome component 6 JBrowse link NW_004936475 23,295,441 23,297,321 RGD:9068941
G Hmces 5-hydroxymethylcytosine binding, ES cell specific JBrowse link NW_004936798 261,566 284,480 RGD:9068941
G Kmt5b lysine methyltransferase 5B JBrowse link NW_004936599 1,928,172 1,983,983 RGD:9068941
G Kmt5c lysine methyltransferase 5C JBrowse link NW_004936886 596,949 602,959 RGD:9068941
G Mad2l2 mitotic arrest deficient 2 like 2 JBrowse link NW_004936474 538,703 542,901 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004936527 9,440,129 9,488,215 RGD:9068941
G Rif1 replication timing regulatory factor 1 JBrowse link NW_004936469 26,045,500 26,105,980 RGD:9068941
G Shld1 shieldin complex subunit 1 JBrowse link NW_004936485 13,179,218 13,267,980 RGD:9068941
G Shld2 shieldin complex subunit 2 JBrowse link NW_004936601 5,315,297 5,400,752 RGD:9068941
G Tfrc transferrin receptor JBrowse link NW_004936784 696,738 728,385 RGD:9068941
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link NW_004936471 6,589,395 6,668,242 RGD:9068941
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mlh1 mutL homolog 1 JBrowse link NW_004936473 26,556,636 26,600,830 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004936508 4,943,987 5,013,356 RGD:9068941
G Nsd2 nuclear receptor binding SET domain protein 2 JBrowse link NW_004936477 21,460,442 21,531,563 RGD:9068941
G Tgfb1 transforming growth factor beta 1 JBrowse link NW_004936661 3,742,080 3,758,266 RGD:9068941
G Tnfsf13 TNF superfamily member 13 JBrowse link NW_004936595 839,877 842,962 RGD:9068941
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcf1 cardiotrophin like cytokine factor 1 JBrowse link NW_004936599 2,372,889 2,376,316 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004936647 2,510,457 2,518,576 RGD:9068941
G Stat6 signal transducer and activator of transcription 6 JBrowse link NW_004936646 1,297,530 1,312,508 RGD:9068941
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atad5 ATPase family AAA domain containing 5 JBrowse link NW_004936538 2,815,370 2,877,084 RGD:9068941
G Cd28 CD28 molecule JBrowse link NW_004936631 335,411 363,407 RGD:9068941
G Cd40 CD40 molecule JBrowse link NW_004936514 6,936,915 6,947,246 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004936662 1,594,953 1,599,625 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004936647 2,510,457 2,518,576 RGD:9068941
G Mlh1 mutL homolog 1 JBrowse link NW_004936473 26,556,636 26,600,830 RGD:9068941
G Msh2 mutS homolog 2 JBrowse link NW_004936508 4,943,987 5,013,356 RGD:9068941
G Paxip1 PAX interacting protein 1 JBrowse link NW_004936527 9,440,129 9,488,215 RGD:9068941
G Ptprc protein tyrosine phosphatase receptor type C JBrowse link NW_004936567 5,266,653 5,378,464 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004936490 13,546,405 13,558,635 RGD:9068941
regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link NW_004936491 12,857,928 12,961,709 RGD:9068941
G Il10 interleukin 10 JBrowse link NW_004936557 5,834,874 5,838,502 RGD:9068941
G Il4 interleukin 4 JBrowse link NW_004936647 2,510,457 2,518,576 RGD:9068941
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link NW_004936538 4,878,645 4,910,613 RGD:9068941
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004936721 1,118,376 1,125,282 RGD:9068941
G Il27ra interleukin 27 receptor subunit alpha JBrowse link NW_004936659 2,706,037 2,720,486 RGD:9068941
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link NW_004936504 12,053,470 12,103,346 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14835
    immune system process 2565
      leukocyte activation 1103
        lymphocyte activation 615
          lymphocyte activation involved in immune response 159
            B cell activation involved in immune response 73
              isotype switching 50
                isotype switching to IgA isotypes + 7
                isotype switching to IgD isotypes + 0
                isotype switching to IgE isotypes + 7
                isotype switching to IgG isotypes + 14
                negative regulation of isotype switching + 5
                positive regulation of isotype switching + 27
                regulation of isotype switching + 36
Path 2
Term Annotations click to browse term
  biological_process 14835
    metabolic process 10258
      cellular metabolic process 9544
        heterocycle metabolic process 5129
          nucleobase-containing compound metabolic process 4979
            nucleic acid metabolic process 4494
              DNA metabolic process 894
                DNA recombination 286
                  somatic cell DNA recombination 67
                    somatic diversification of immune receptors via germline recombination within a single locus 67
                      somatic recombination of immunoglobulin gene segments 55
                        somatic recombination of immunoglobulin genes involved in immune response 50
                          isotype switching 50
                            isotype switching to IgA isotypes + 7
                            isotype switching to IgD isotypes + 0
                            isotype switching to IgE isotypes + 7
                            isotype switching to IgG isotypes + 14
                            negative regulation of isotype switching + 5
                            positive regulation of isotype switching + 27
                            regulation of isotype switching + 36
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.