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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of isotype switching
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Accession:GO:0045191 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: regulation of class switch recombination;   regulation of class switching;   regulation of isotype switch recombination


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regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APLF aprataxin and PNKP like factor JBrowse link 10 67,454,500 67,522,659 RGD:13508589
G SUPT6H SPT6 homolog, histone chaperone and transcription elongation factor JBrowse link 9 42,859,154 42,896,044 RGD:13508589
negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 20 37,767,336 37,774,269 RGD:13508589
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G THOC1 THO complex 1 JBrowse link 7 67,082,100 67,136,592 RGD:13508589
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 34 20,112,302 20,135,705 RGD:13508589
positive regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EXOSC3 exosome component 3 JBrowse link 11 54,072,993 54,079,024 RGD:13508589
G HMCES 5-hydroxymethylcytosine binding, ES cell specific JBrowse link 20 2,808,687 2,831,123 RGD:13508589
G KMT5B lysine methyltransferase 5B JBrowse link 18 49,655,783 49,691,899 RGD:13508589
G KMT5C lysine methyltransferase 5C JBrowse link 1 102,334,687 102,342,090 RGD:13508589
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 2 84,539,724 84,549,402 RGD:13508589
G RIF1 replication timing regulatory factor 1 JBrowse link 19 52,661,278 52,711,969 RGD:13508589
G SHLD1 shieldin complex subunit 1 JBrowse link 24 15,957,863 16,037,336 RGD:13508589
G TFRC transferrin receptor JBrowse link 33 29,206,024 29,237,221 RGD:13508589
G TP53BP1 tumor protein p53 binding protein 1 JBrowse link 30 10,263,650 10,362,646 RGD:13508589
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B9D2 B9 domain containing 2 JBrowse link 1 112,621,832 112,627,726 RGD:13508589
G MLH1 mutL homolog 1 JBrowse link 23 6,889,108 6,938,117 RGD:13508589
G MSH2 mutS homolog 2 JBrowse link 10 49,517,448 49,594,001 RGD:13508589
G NSD2 nuclear receptor binding SET domain protein 2 JBrowse link 3 62,164,888 62,228,006 RGD:13508589
G TGFB1 transforming growth factor beta 1 JBrowse link 1 112,629,476 112,643,885 RGD:13508589
G TNFSF13 TNF superfamily member 13 JBrowse link 5 32,482,723 32,484,790 RGD:13508589
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ATAD5 ATPase family AAA domain containing 5 JBrowse link 9 40,869,778 40,917,976 RGD:13508589
G CD40 CD40 molecule JBrowse link 24 33,352,992 33,383,488 RGD:13508589
G IL2 interleukin 2 JBrowse link 19 17,750,780 17,756,394 RGD:13508589
G IL4 interleukin 4 JBrowse link 11 20,972,693 20,981,539 RGD:13508589
G MLH1 mutL homolog 1 JBrowse link 23 6,889,108 6,938,117 RGD:13508589
G MSH2 mutS homolog 2 JBrowse link 10 49,517,448 49,594,001 RGD:13508589
G PAXIP1 PAX interacting protein 1 JBrowse link 16 18,066,289 18,116,007 RGD:13508589
G TBX21 T-box transcription factor 21 JBrowse link 9 24,077,752 24,086,560 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14453
    multicellular organismal process 4889
      multicellular organism development 3130
        regulation of multicellular organismal development 1205
          regulation of isotype switching 26
            negative regulation of isotype switching + 3
            positive regulation of isotype switching + 21
            regulation of isotype switching to IgA isotypes + 7
            regulation of isotype switching to IgD isotypes + 0
            regulation of isotype switching to IgE isotypes + 2
            regulation of isotype switching to IgG isotypes + 8
Path 2
Term Annotations click to browse term
  biological_process 14453
    cellular process 13629
      cellular metabolic process 8186
        cellular nitrogen compound metabolic process 4711
          nucleobase-containing compound metabolic process 4061
            nucleic acid metabolic process 3673
              DNA metabolic process 619
                DNA recombination 209
                  somatic cell DNA recombination 46
                    somatic diversification of immune receptors via germline recombination within a single locus 46
                      somatic recombination of immunoglobulin gene segments 39
                        somatic recombination of immunoglobulin genes involved in immune response 34
                          isotype switching 34
                            regulation of isotype switching 26
                              negative regulation of isotype switching + 3
                              positive regulation of isotype switching + 21
                              regulation of isotype switching to IgA isotypes + 7
                              regulation of isotype switching to IgD isotypes + 0
                              regulation of isotype switching to IgE isotypes + 2
                              regulation of isotype switching to IgG isotypes + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.