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ONTOLOGY REPORT - ANNOTATIONS


Term:synapse
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Accession:GO:0045202 term browser browse the term
Definition:The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Synonyms:exact_synonym: synaptic junction
 narrow_synonym: mixed synapse
 related_synonym: electrotonic synapse
 xref: NIF_Subcellular:sao914572699;   Wikipedia:Chemical_synapse
 only_in_taxon: NCBITaxon:33208 ! Metazoa


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  cellular_component 132215
    cellular anatomical entity 126642
      cell junction 15984
        synapse 11472
          GABA-ergic synapse + 856
          Schaffer collateral - CA1 synapse 922
          cerebellar Golgi cell to granule cell synapse 8
          cholinergic synapse + 127
          dopaminergic synapse 127
          excitatory synapse + 619
          glutamatergic synapse + 4108
          glycinergic synapse 103
          inhibitory synapse + 194
          neuromuscular junction + 738
          neuron to neuron synapse + 3513
          noradrenergic synapse 0
          perforant pathway to dendrate granule cell synapse 0
          polyadic synapse 0
          postsynapse + 5774
          presynapse + 4882
          ribbon synapse + 181
          serotonergic synapse 24
          synaptic cleft + 173
          synaptic membrane + 3491
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.