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ONTOLOGY REPORT - ANNOTATIONS


Term:oxoglutarate dehydrogenase complex
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Accession:GO:0045252 term browser browse the term
Definition:A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).
Comment:See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
Synonyms:exact_synonym: dihydrolipoamide S-succinyltransferase complex


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oxoglutarate dehydrogenase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhtkd1 dehydrogenase E1 and transketolase domain containing 1 JBrowse link 17 76,306,585 76,358,058 RGD:13792537
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:2306876
RGD:13792537
RGD:1624291
G Dlst dihydrolipoamide S-succinyltransferase JBrowse link 6 108,936,534 108,961,322 RGD:1359804
RGD:1624291
RGD:1600115
RGD:2306876
G Kat2a lysine acetyltransferase 2A JBrowse link 10 88,611,586 88,619,558 RGD:1624291
G LOC103693780 2-oxoglutarate dehydrogenase, mitochondrial-like JBrowse link 14 86,599,906 86,614,963 RGD:13792537
G Ogdh oxoglutarate dehydrogenase JBrowse link 14 86,414,924 86,481,903 RGD:2306876
RGD:13792537
RGD:1624291
G Ogdhl oxoglutarate dehydrogenase L JBrowse link 16 8,497,495 8,523,552 RGD:13792537
mitochondrial oxoglutarate dehydrogenase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mrps36 mitochondrial ribosomal protein S36 JBrowse link 2 30,740,620 30,750,916 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19949
    protein-containing complex 5829
      tricarboxylic acid cycle enzyme complex 18
        dihydrolipoyl dehydrogenase complex 11
          oxoglutarate dehydrogenase complex 8
            cytosolic oxoglutarate dehydrogenase complex 0
            mitochondrial oxoglutarate dehydrogenase complex 1
Path 2
Term Annotations click to browse term
  cellular_component 19949
    protein-containing complex 5829
      catalytic complex 1451
        oxidoreductase complex 129
          dihydrolipoyl dehydrogenase complex 11
            oxoglutarate dehydrogenase complex 8
              cytosolic oxoglutarate dehydrogenase complex 0
              mitochondrial oxoglutarate dehydrogenase complex 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.