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ONTOLOGY REPORT - ANNOTATIONS


Term:pyruvate dehydrogenase complex
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Accession:GO:0045254 term browser browse the term
Definition:Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
Comment:Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
Synonyms:exact_synonym: pyruvate dehydrogenase complex (lipoamide)
 broad_synonym: dihydrolipoyl dehydrogenase complex
 alt_id: GO:0009364
 xref: Wikipedia:Pyruvate_dehydrogenase_complex


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pyruvate dehydrogenase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:728205
RGD:1624291
RGD:1599112
G Dld dihydrolipoamide dehydrogenase JBrowse link 6 50,597,677 50,618,694 RGD:1599112
RGD:1624291
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:1599112
RGD:1624291
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 JBrowse link 2 246,736,449 246,737,997 RGD:1599112
G Pdhb pyruvate dehydrogenase E1 subunit beta JBrowse link 15 18,540,826 18,546,855 RGD:1599112
RGD:1600115
RGD:1624291
G Pdhx pyruvate dehydrogenase complex, component X JBrowse link 3 92,910,300 92,933,725 RGD:1624291
RGD:13792537
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:2307429
G Pdk2 pyruvate dehydrogenase kinase 2 JBrowse link 10 82,838,270 82,852,758 RGD:2307429
mitochondrial pyruvate dehydrogenase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dlat dihydrolipoamide S-acetyltransferase JBrowse link 8 55,062,549 55,087,832 RGD:13792537
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:729480
RGD:13792537
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 JBrowse link 2 246,736,449 246,737,997 RGD:13792537
G Pdhb pyruvate dehydrogenase E1 subunit beta JBrowse link 15 18,540,826 18,546,855 RGD:13792537
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1600115
RGD:1624291
G Pdk2 pyruvate dehydrogenase kinase 2 JBrowse link 10 82,838,270 82,852,758 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19951
    intracellular 13934
      cytoplasm 10687
        pyruvate dehydrogenase complex 8
          cytosolic pyruvate dehydrogenase complex 0
          mitochondrial pyruvate dehydrogenase complex 6
          plastid pyruvate dehydrogenase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 19951
    protein-containing complex 5828
      catalytic complex 1451
        oxidoreductase complex 129
          pyruvate dehydrogenase complex 8
            cytosolic pyruvate dehydrogenase complex 0
            mitochondrial pyruvate dehydrogenase complex 6
            plastid pyruvate dehydrogenase complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.