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ONTOLOGY REPORT - ANNOTATIONS


Term:MHC class II biosynthetic process
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Accession:GO:0045342 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.
Synonyms:exact_synonym: MHC class II anabolism;   MHC class II biosynthesis;   MHC class II formation;   MHC class II synthesis;   major histocompatibility complex class II biosynthesis;   major histocompatibility complex class II biosynthetic process


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MHC class II biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc11a1 solute carrier family 11 member 1 ISO
IEA
MGI:MGI:1857755 (MGI:MGI:64652|PMID:8301134)
GO_REF:0000107
RGD
Ensembl
PMID:8301134 GO_REF:0000107, MGI:MGI:64652 NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
JBrowse link
negative regulation of MHC class II biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO (PMID:1940799) RGD PMID:1940799 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Marchf8 membrane associated ring-CH-type finger 8 ISO (MGI:MGI:3785681|PMID:16785530) RGD PMID:16785530 MGI:MGI:3785681 NCBI chr 4:148,285,467...148,398,148
Ensembl chr 4:148,286,853...148,398,148
JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 ISO (MGI:MGI:2180954|PMID:12047746) RGD PMID:12047746 MGI:MGI:2180954 NCBI chr 5:57,290,916...57,348,720
Ensembl chr 5:57,291,156...57,348,720
JBrowse link
G Pf4 platelet factor 4 ISO (PMID:10666185) RGD PMID:10666185 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Spi1 Spi-1 proto-oncogene ISO (MGI:MGI:4942273|PMID:7592651) RGD PMID:7592651 MGI:MGI:4942273 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 ISO (PMID:20937824) RGD PMID:20937824 NCBI chr18:30,779,149...30,781,297
Ensembl chr18:30,779,150...30,781,292
JBrowse link
positive regulation of MHC class II biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40lg CD40 ligand IDA RGD PMID:18262271 RGD:2313421 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO (PMID:29020624) RGD PMID:29020624 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator IEP
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:11477547, PMID:21873635, PMID:11071855 RGD:632487, RGD:13792537, RGD:632488 NCBI chr10:5,212,621...5,260,641
Ensembl chr10:5,213,350...5,260,608
JBrowse link
G Ifng interferon gamma IEP
ISO
UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:3033882|PMID:11027433), (MGI:MGI:4942276|PMID:2502420), (MGI:MGI:4942277|PMID:2493384), (MGI:MGI:4943415|PMID:1845803), (MGI:MGI:5776417|PMID:26227742) RGD PMID:1845803, PMID:2493384, PMID:2502420, PMID:11027433, PMID:26227742, PMID:3127329 MGI:MGI:3033882, MGI:MGI:4942276, MGI:MGI:4942277, MGI:MGI:4943415, MGI:MGI:5776417, RGD:8547557 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 ISO (MGI:MGI:3033882|PMID:11027433) RGD PMID:11027433 MGI:MGI:3033882 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il33 interleukin 33 ISO
IEA
(MGI:MGI:6414704|PMID:26936882)
GO_REF:0000107
RGD
Ensembl
PMID:26936882 GO_REF:0000107, MGI:MGI:6414704 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:2178646|PMID:10549626), (MGI:MGI:3033882|PMID:11027433)
PMID:21873635
RGD PMID:10549626, PMID:11027433, PMID:21873635 MGI:MGI:2178646, MGI:MGI:3033882, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Jak2 Janus kinase 2 ISO UniProtKB:P01580 (MGI:MGI:5776417|PMID:26227742) RGD PMID:26227742 MGI:MGI:5776417 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:21890893)
GO_REF:0000107
RGD
Ensembl
PMID:21890893 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEA
MGI:MGI:1860885 (MGI:MGI:2178646|PMID:10549626)
GO_REF:0000107
RGD
Ensembl
PMID:10549626 GO_REF:0000107, MGI:MGI:2178646 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tmem106a transmembrane protein 106A ISS
ISO
GO_REF:0000024
(MGI:MGI:6216178|PMID:26215746)
UniProt
RGD
PMID:26215746 GO_REF:0000024, MGI:MGI:6216178 NCBI chr10:89,484,269...89,493,288
Ensembl chr10:89,484,468...89,493,283
JBrowse link
G Xbp1 X-box binding protein 1 ISO
ISS
(PMID:1903538)
GO_REF:0000024
RGD
UniProt
PMID:1903538 GO_REF:0000024 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        macromolecule metabolic process 10081
          macromolecule biosynthetic process 5161
            MHC class II biosynthetic process 18
              negative regulation of MHC class II biosynthetic process 6
              positive regulation of MHC class II biosynthetic process 12
              regulation of MHC class II biosynthetic process + 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.