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ONTOLOGY REPORT - ANNOTATIONS


Term:endothelial cell differentiation
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Accession:GO:0045446 term browser browse the term
Definition:The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.


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endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr4 C-X-C motif chemokine receptor 4 IMP RGD PMID:24955809 RGD:11352686 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Fstl1 follistatin-like 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:4457221|PMID:20054002)
UniProt
RGD
PMID:20054002 GO_REF:0000024, MGI:MGI:4457221 NCBI chr11:65,791,196...65,845,721
Ensembl chr11:65,782,567...65,845,418
JBrowse link
G Hoxb5 homeo box B5 ISO (MGI:MGI:2670246|PMID:12897140) RGD PMID:12897140 MGI:MGI:2670246 NCBI chr10:84,152,152...84,154,360
Ensembl chr10:84,152,152...84,154,360
JBrowse link
G Kdm6b lysine demethylase 6B ISO (MGI:MGI:5574281|PMID:23856522) RGD PMID:23856522 MGI:MGI:5574281 NCBI chr10:56,000,494...56,009,582
Ensembl chr10:56,001,799...56,008,885
JBrowse link
G Kdr kinase insert domain receptor IBA
ISO
PMID:21873635
(MGI:MGI:2670246|PMID:12897140), (MGI:MGI:5543371|PMID:18772315)
RGD PMID:12897140, PMID:18772315, PMID:21873635 MGI:MGI:2670246, MGI:MGI:5543371, RGD:13792537 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (PMID:18297060) RGD PMID:18297060 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Notch4 notch receptor 4 IDA RGD PMID:10964583 RGD:1304484 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Prox1 prospero homeobox 1 ISO MGI:MGI:2386336 (MGI:MGI:2177970|PMID:11927535) RGD PMID:11927535 MGI:MGI:2177970 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Ptn pleiotrophin IEP RGD PMID:20830586 RGD:9686141 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IEP RGD PMID:7959012 RGD:61573 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
arterial endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO UniProtKB:Q9QUS4 (MGI:MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:MGI:3040159 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO UniProtKB:Q9WV93 (MGI:MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:MGI:3040159 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:MGI:3040159|PMID:15107403) RGD PMID:15107403 MGI:MGI:3040159 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Tmem100 transmembrane protein 100 ISO MGI:MGI:5432904|MGI:MGI:5432905 (MGI:MGI:5432418|PMID:22783020) RGD PMID:22783020 MGI:MGI:5432418 NCBI chr10:77,537,340...77,543,710
Ensembl chr10:77,537,340...77,543,192
JBrowse link
arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO (MGI:MGI:3056004|PMID:15466160) RGD PMID:15466160 MGI:MGI:3056004 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein ISO MGI:MGI:3512761 (MGI:MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:MGI:3837878 NCBI chr14:86,812,728...86,859,408
Ensembl chr14:86,813,082...86,859,406
JBrowse link
blood vessel endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbpj recombination signal binding protein for immunoglobulin kappa J region ISO UniProtKB:P52800 (MGI:MGI:3056004|PMID:15466160) RGD PMID:15466160 MGI:MGI:3056004 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
central nervous system vasculogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 ISO
IEA
MGI:MGI:2148569 (MGI:MGI:3821408|PMID:19023080)
GO_REF:0000107
RGD
Ensembl
PMID:19023080 GO_REF:0000107, MGI:MGI:3821408 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Eng endoglin ISO (PMID:7894484) RGD PMID:7894484 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Rtn4 reticulon 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:5492189|PMID:23625008)
UniProt
RGD
PMID:23625008 GO_REF:0000024, MGI:MGI:5492189 NCBI chr14:114,126,931...114,174,459
Ensembl chr14:114,126,943...114,174,458
JBrowse link
G Wnt7a Wnt family member 7A ISO MGI:MGI:98962 (MGI:MGI:3821408|PMID:19023080) RGD PMID:19023080 MGI:MGI:3821408 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
G Wnt7b Wnt family member 7B ISO MGI:MGI:98961 (MGI:MGI:3821408|PMID:19023080) RGD PMID:19023080 MGI:MGI:3821408 NCBI chr 7:126,423,418...126,465,724
Ensembl chr 7:126,420,656...126,465,723
JBrowse link
endocardial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 ISO (MGI:MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:MGI:4837019 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nrg1 neuregulin 1 ISO
IEA
(PMID:17336907)
GO_REF:0000107
RGD
Ensembl
PMID:17336907 GO_REF:0000107 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Smad4 SMAD family member 4 ISO
IEA
(MGI:MGI:4946551|PMID:21330551)
GO_REF:0000107
RGD
Ensembl
PMID:21330551 GO_REF:0000107, MGI:MGI:4946551 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sox17 SRY-box transcription factor 17 ISO MGI:MGI:103559 (MGI:MGI:3716256|PMID:17610846) RGD PMID:17610846 MGI:MGI:3716256 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sox18 SRY-box transcription factor 18 ISO MGI:MGI:107543 (MGI:MGI:3716256|PMID:17610846) RGD PMID:17610846 MGI:MGI:3716256 NCBI chr 3:177,177,237...177,179,039
Ensembl chr 3:177,177,310...177,179,127
JBrowse link
endocardial cushion cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO
IEA
(PMID:19506109)
GO_REF:0000107
RGD
Ensembl
PMID:19506109 GO_REF:0000107 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930
JBrowse link
endothelial cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccm2 CCM2 scaffold protein ISO MGI:MGI:1924696|MGI:MGI:3512761 (MGI:MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:MGI:3837878 NCBI chr14:86,812,728...86,859,408
Ensembl chr14:86,813,082...86,859,406
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO
IEA
MGI:MGI:2158814 (MGI:MGI:3698597|PMID:16373599)
GO_REF:0000107
RGD
Ensembl
PMID:16373599 GO_REF:0000107, MGI:MGI:3698597 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 ISO MGI:MGI:2384924 (MGI:MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:MGI:3837878 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690
JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:165,247,630...165,259,228
Ensembl chr 5:165,247,133...165,259,224
JBrowse link
G Vezf1 vascular endothelial zinc finger 1 ISO MGI:MGI:3583268 (MGI:MGI:3581991|PMID:15882861) RGD PMID:15882861 MGI:MGI:3581991 NCBI chr10:75,365,763...75,382,014
Ensembl chr10:75,365,822...75,381,555
JBrowse link
endothelial cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxa13 homeo box A13 ISO MGI:MGI:2152356 (MGI:MGI:3797428|PMID:18483557) RGD PMID:18483557 MGI:MGI:3797428 Ensembl chr 4:82,228,017...82,229,397 JBrowse link
endothelial cell morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef26 Rho guanine nucleotide exchange factor 26 ISO MGI:MGI:5500046 (MGI:MGI:5486234|PMID:23372835) RGD PMID:23372835 MGI:MGI:5486234 NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
JBrowse link
G Clic4 chloride intracellular channel 4 ISO
IEA
MGI:MGI:3838012 (MGI:MGI:3837628|PMID:19197003)
GO_REF:0000107
RGD
Ensembl
PMID:19197003 GO_REF:0000107, MGI:MGI:3837628 NCBI chr 5:153,568,937...153,625,669
Ensembl chr 5:153,568,745...153,625,869
JBrowse link
G Cnmd chondromodulin ISO
IBA
(MGI:MGI:2656472|PMID:12714610)
PMID:21873635
RGD PMID:12714610, PMID:21873635 MGI:MGI:2656472, RGD:13792537 NCBI chr15:61,923,291...61,947,840
Ensembl chr15:61,923,299...61,947,764
JBrowse link
G Col15a1 collagen type XV alpha 1 chain IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:62,840,360...62,950,240 JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain ISO
IBA
(MGI:MGI:3046127|PMID:15188432)
PMID:21873635
RGD PMID:15188432, PMID:21873635 MGI:MGI:3046127, RGD:13792537 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col22a1 collagen type XXII alpha 1 chain IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:113,014,896...113,251,165
Ensembl chr 7:113,015,747...113,228,439
JBrowse link
G Col24a1 collagen type XXIV alpha 1 chain IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:251,200,686...251,436,254
Ensembl chr 2:251,200,686...251,434,932
JBrowse link
G Heg1 heart development protein with EGF-like domains 1 ISO MGI:MGI:3838392 (MGI:MGI:3837878|PMID:19151727) RGD PMID:19151727 MGI:MGI:3837878 NCBI chr11:70,234,248...70,322,966
Ensembl chr11:70,236,888...70,322,690
JBrowse link
G Hoxa13 homeo box A13 ISO MGI:MGI:2152356 (MGI:MGI:3797428|PMID:18483557) RGD PMID:18483557 MGI:MGI:3797428 Ensembl chr 4:82,228,017...82,229,397 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein ISO MGI:MGI:2679939 (MGI:MGI:3759000|PMID:17717145) RGD PMID:17717145 MGI:MGI:3759000 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Ift88 intraflagellar transport 88 ISO MGI:MGI:2157527 (MGI:MGI:4940123|PMID:21285373) RGD PMID:21285373 MGI:MGI:4940123 NCBI chr15:37,690,417...37,786,855
Ensembl chr15:37,691,345...37,784,924
JBrowse link
G LOC108348074 collagen alpha-1(XV) chain-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:64,475,618...64,543,510 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase IEA
ISO
GO_REF:0000107
(PMID:14500721)
Ensembl
RGD
PMID:14500721 GO_REF:0000107 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Notch4 notch receptor 4 IDA RGD PMID:10964583 RGD:1304484 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO MGI:MGI:2677448 (MGI:MGI:3723364|PMID:17563397) RGD PMID:17563397 MGI:MGI:3723364 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ISO MGI:MGI:3620600|MGI:MGI:3620601 (MGI:MGI:3618677|PMID:16467571) RGD PMID:16467571 MGI:MGI:3618677 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Stc1 stanniocalcin 1 ISO (PMID:14500721) RGD PMID:14500721 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Tnmd tenomodulin ISO
IBA
(MGI:MGI:2656472|PMID:12714610)
PMID:21873635
RGD PMID:12714610, PMID:21873635 MGI:MGI:2656472, RGD:13792537 NCBI chr  X:104,684,676...104,700,173
Ensembl chr  X:104,684,676...104,700,173
JBrowse link
endothelial tip cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5466218|PMID:22282195)
Ensembl
UniProt
RGD
PMID:22282195 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5466218 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
establishment of blood-nerve barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISO MGI:MGI:2136636 (MGI:MGI:2385816|PMID:9734405) RGD PMID:9734405 MGI:MGI:2385816 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cldn1 claudin 1 IMP RGD PMID:22733753 RGD:11341802 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Dmd dystrophin ISO MGI:MGI:1856328 (MGI:MGI:3612931|PMID:12673830) RGD PMID:12673830 MGI:MGI:3612931 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Hapln2 hyaluronan and proteoglycan link protein 2 ISO
IEA
MGI:MGI:4437572 (MGI:MGI:4437139|PMID:20181608)
GO_REF:0000107
RGD
Ensembl
PMID:20181608 GO_REF:0000107, MGI:MGI:4437139 NCBI chr 2:187,395,104...187,402,076
Ensembl chr 2:187,396,349...187,401,786
JBrowse link
G Ren renin NOT ISO MGI:MGI:2136642 (MGI:MGI:1351364|PMID:10617578) RGD PMID:10617578 MGI:MGI:1351364 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cldn5 claudin 5 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Ezr ezrin ISO UniProtKB:P26038|UniProtKB:P35241 (PMID:23264465) RGD PMID:23264465 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:20826780) RGD PMID:20826780 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO UniProtKB:Q96S97 (PMID:23264465) RGD PMID:23264465 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Marveld2 MARVEL domain containing 2 ISO (PMID:23073616) RGD PMID:23073616 NCBI chr 2:30,612,746...30,634,308
Ensembl chr 2:30,612,106...30,634,243
JBrowse link
G Msn moesin IEA
ISO
GO_REF:0000107
UniProtKB:P15311|UniProtKB:P35241 (PMID:23264465)
Ensembl
RGD
PMID:23264465 GO_REF:0000107 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Myadm myeloid-associated differentiation marker ISO (PMID:23264465) RGD PMID:23264465 NCBI chr 1:64,438,465...64,448,332
Ensembl chr 1:64,438,472...64,446,818
JBrowse link
G Pde2a phosphodiesterase 2A IDA PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde4d phosphodiesterase 4D IDA PMID:20139324 UniProt PMID:20139324 RGD:8553884 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO (PMID:7589563) RGD PMID:7589563 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Ppp1r16b protein phosphatase 1, regulatory subunit 16B ISO
IBA
(MGI:MGI:5604907|PMID:21907835)
PMID:21873635
(PMID:18586956)
RGD PMID:18586956, PMID:21907835, PMID:21873635 MGI:MGI:5604907, RGD:13792537 NCBI chr 3:155,160,474...155,267,002
Ensembl chr 3:155,160,481...155,262,941
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO
ISS
(PMID:21840392)
GO_REF:0000024
RGD
UniProt
PMID:21840392 GO_REF:0000024 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO
ISS
(PMID:21840392)
GO_REF:0000024
RGD
UniProt
PMID:21840392 GO_REF:0000024 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO (PMID:21840392) RGD PMID:21840392 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 ISO
ISS
(PMID:21840392)
GO_REF:0000024
RGD
UniProt
PMID:21840392 GO_REF:0000024 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 ISO
IEA
ISS
(PMID:21840392)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:21840392 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:139,232,263...139,254,668
Ensembl chr 7:139,232,251...139,254,551
JBrowse link
G Rdx radixin ISO UniProtKB:P15311|UniProtKB:P26038 (PMID:23264465) RGD PMID:23264465 NCBI chr 8:56,570,728...56,612,851
Ensembl chr 8:56,585,396...56,610,612
JBrowse link
G Robo4 roundabout guidance receptor 4 ISO (PMID:30455415) RGD PMID:30455415 NCBI chr 8:39,082,693...39,093,344
Ensembl chr 8:39,083,327...39,093,277
JBrowse link
G Sox18 SRY-box transcription factor 18 ISO (PMID:18065521) RGD PMID:18065521 NCBI chr 3:177,177,237...177,179,039
Ensembl chr 3:177,177,310...177,179,127
JBrowse link
establishment of endothelial blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B IMP RGD PMID:16850390 RGD:1598561 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cldn3 claudin 3 ISO (MGI:MGI:6368952|PMID:12734665) RGD PMID:12734665 MGI:MGI:6368952 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Foxp3 forkhead box P3 IEP RGD PMID:31027862 RGD:38549575 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
establishment of endothelial intestinal barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afdn afadin, adherens junction formation factor ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658
JBrowse link
G Cldn1 claudin 1 IMP RGD PMID:22684624 RGD:11341733 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G F11r F11 receptor ISO
IBA
UniProtKB:Q9Y3L5 (PMID:23885123)
PMID:21873635
RGD PMID:23885123, PMID:21873635 RGD:13792537 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Fasn fatty acid synthase ISO MGI:MGI:3765070 (MGI:MGI:5630041|PMID:25565205) RGD PMID:25565205 MGI:MGI:5630041 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Icam1 intercellular adhesion molecule 1 IMP RGD PMID:10201790 RGD:11520782 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mir874 microRNA 874 ISO (MGI:MGI:5551666|PMID:24462679) RGD PMID:24462679 MGI:MGI:5551666 NCBI chr17:7,025,014...7,025,089
Ensembl chr17:7,025,014...7,025,089
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO MGI:MGI:2385681 (MGI:MGI:5306517|PMID:22155109) RGD PMID:22155109 MGI:MGI:5306517 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S ISO
IEA
MGI:MGI:2158734 (MGI:MGI:5550154|PMID:24385580)
GO_REF:0000107
RGD
Ensembl
PMID:24385580 GO_REF:0000107, MGI:MGI:5550154 NCBI chr 9:10,585,360...10,646,205
Ensembl chr 9:10,603,813...10,645,939
JBrowse link
G Rab1a RAB1A, member RAS oncogene family NOT ISO (PMID:23885123) RGD PMID:23885123 NCBI chr14:104,475,082...104,500,176
Ensembl chr14:104,475,082...104,501,020
JBrowse link
G Rab1b RAB1B, member RAS oncogene family NOT ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 1:220,483,529...220,491,469
Ensembl chr 1:220,480,834...220,491,469
JBrowse link
G Rap2b RAP2B, member of RAS oncogene family NOT ISO (PMID:23885123) RGD PMID:23885123 NCBI chr 2:151,685,251...151,685,802
Ensembl chr 2:151,685,251...151,685,802
JBrowse link
G Rap2c RAP2C, member of RAS oncogene family ISO UniProtKB:Q9Y624 (PMID:23885123) RGD PMID:23885123 NCBI chr  X:138,224,039...138,237,157
Ensembl chr  X:138,224,040...138,237,157
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 IEA
ISO
GO_REF:0000107
(PMID:23885123)
Ensembl
RGD
PMID:23885123 GO_REF:0000107 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Rapgef6 Rap guanine nucleotide exchange factor 6 NOT ISO (PMID:23885123) RGD PMID:23885123 NCBI chr10:39,875,322...40,039,929
Ensembl chr10:39,875,371...40,039,929
JBrowse link
G Tjp1 tight junction protein 1 ISO
IBA
(PMID:23885123)
PMID:21873635
RGD PMID:23885123, PMID:21873635 RGD:13792537 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tjp2 tight junction protein 2 ISO
IBA
(PMID:23885123)
PMID:21873635
RGD PMID:23885123, PMID:21873635 RGD:13792537 NCBI chr 1:241,945,816...242,084,044
Ensembl chr 1:241,945,841...242,083,484
JBrowse link
G Tjp3 tight junction protein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:11,295,892...11,314,535
Ensembl chr 7:11,295,892...11,315,615
JBrowse link
lymphatic endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr2b activin A receptor type 2B ISO
IEA
(MGI:MGI:4436974|PMID:19903896)
GO_REF:0000107
RGD
Ensembl
PMID:19903896 GO_REF:0000107, MGI:MGI:4436974 NCBI chr 8:128,087,308...128,126,776
Ensembl chr 8:128,087,345...128,118,746
JBrowse link
G Acvrl1 activin A receptor like type 1 ISO (PMID:19903896)
(MGI:MGI:4436974|PMID:19903896)
RGD PMID:19903896 MGI:MGI:4436974 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO (MGI:MGI:4436974|PMID:19903896) RGD PMID:19903896 MGI:MGI:4436974 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:12198161)
MGI:MGI:2182767|MGI:MGI:3609548 (MGI:MGI:3820329|PMID:19056883)
RGD PMID:12198161, PMID:19056883 MGI:MGI:3820329 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
G Sox18 SRY-box transcription factor 18 ISO MGI:MGI:2178809 (MGI:MGI:3828192|PMID:18931657) RGD PMID:18931657 MGI:MGI:3828192 NCBI chr 3:177,177,237...177,179,039
Ensembl chr 3:177,177,310...177,179,127
JBrowse link
lymphatic endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdpn podoplanin ISO
ISS
(MGI:MGI:4453945|PMID:20110424)
GO_REF:0000024
RGD
UniProt
PMID:20110424 GO_REF:0000024, MGI:MGI:4453945 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
negative regulation of blood vessel endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxj2 forkhead box J2 ISO (PMID:24792364) RGD PMID:24792364 NCBI chr 4:155,653,446...155,679,815
Ensembl chr 4:155,653,718...155,679,793
JBrowse link
negative regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 ISO (MGI:MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:MGI:4830635 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein IMP RGD PMID:20830586 RGD:9686141 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Jag1 jagged canonical Notch ligand 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5661129|PMID:25535084)
Ensembl
RGD
PMID:25535084 GO_REF:0000107, MGI:MGI:5661129 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Notch4 notch receptor 4 ISO (MGI:MGI:1934537|PMID:11344305) RGD PMID:11344305 MGI:MGI:1934537 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IMP RGD PMID:17450384 RGD:2302022 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO MGI:MGI:2136645|MGI:MGI:3608931 (MGI:MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:MGI:5618205 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
G Xdh xanthine dehydrogenase IEA
ISO
GO_REF:0000107
(PMID:18386220)
Ensembl
RGD
PMID:18386220 GO_REF:0000107 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 ISO
IEA
(PMID:23765923)
GO_REF:0000107
RGD
Ensembl
PMID:23765923 GO_REF:0000107 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
negative regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G S1pr3 sphingosine-1-phosphate receptor 3 ISO (PMID:24851274) RGD PMID:24851274 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:20048167) RGD PMID:20048167 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Notch signaling pathway involved in arterial endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3847069|PMID:19144989)
Ensembl
UniProt
RGD
PMID:19144989 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3847069 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
positive regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 ISO (MGI:MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:MGI:4830635 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 ISO (PMID:24463812) RGD PMID:24463812 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO
IEA
(MGI:MGI:4830635|PMID:20406889)
GO_REF:0000107
RGD
Ensembl
PMID:20406889 GO_REF:0000107, MGI:MGI:4830635 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO (MGI:MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:MGI:4830635 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Btg1 BTG anti-proliferation factor 1 ISO
ISS
(PMID:15033446)
GO_REF:0000024
RGD
UniProt
PMID:15033446 GO_REF:0000024 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G Ctnnb1 catenin beta 1 ISO
IEA
MGI:MGI:2148567 (MGI:MGI:3773938|PMID:18231602)
GO_REF:0000107
RGD
Ensembl
PMID:18231602 GO_REF:0000107, MGI:MGI:3773938 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Etv2 ETS variant transcription factor 2 ISO (MGI:MGI:4415813|PMID:18462699) RGD PMID:18462699 MGI:MGI:4415813 NCBI chr 1:89,091,239...89,094,570
Ensembl chr 1:89,091,239...89,094,530
JBrowse link
G Gdf2 growth differentiation factor 2 ISO (MGI:MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:MGI:4830635 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Notch1 notch receptor 1 IMP RGD PMID:19109527 RGD:2325303 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Tmem100 transmembrane protein 100 ISO (MGI:MGI:5432418|PMID:22783020) RGD PMID:22783020 MGI:MGI:5432418 NCBI chr10:77,537,340...77,543,710
Ensembl chr10:77,537,340...77,543,192
JBrowse link
G Vezf1 vascular endothelial zinc finger 1 ISO (PMID:27538588) RGD PMID:27538588 NCBI chr10:75,365,763...75,382,014
Ensembl chr10:75,365,822...75,381,555
JBrowse link
positive regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:MGI:5796260|PMID:25978380)
(PMID:25978380)
Ensembl
RGD
PMID:25978380, PMID:21873635 GO_REF:0000107, MGI:MGI:5796260, RGD:13792537 NCBI chr14:81,367,466...81,426,610
Ensembl chr14:81,367,468...81,426,496
JBrowse link
G Akap11 A-kinase anchoring protein 11 IMP RGD PMID:25188285 RGD:14348953 NCBI chr15:60,722,138...60,766,673
Ensembl chr15:60,722,160...60,766,579
JBrowse link
G Cdh5 cadherin 5 ISO (PMID:23288152) RGD PMID:23288152 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cldn5 claudin 5 ISO (PMID:23288152) RGD PMID:23288152 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G F11r F11 receptor ISO (PMID:26985018) RGD PMID:26985018 NCBI chr13:89,826,272...89,850,151
Ensembl chr13:89,826,254...89,850,612
JBrowse link
G Il4 interleukin 4 ISO (PMID:24280217) RGD PMID:24280217 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:25651845)
Ensembl
UniProt
RGD
PMID:25651845 GO_REF:0000024, GO_REF:0000107 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO (PMID:24851274) RGD PMID:24851274 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
regulation of endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apold1 apolipoprotein L domain containing 1 IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:15102925, PMID:21873635 RGD:1303988, RGD:13792537 NCBI chr 4:168,752,142...168,755,024
Ensembl chr 4:168,752,133...168,755,023
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A NOT ISO (MGI:MGI:4830635|PMID:20406889) RGD PMID:20406889 MGI:MGI:4830635 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO
ISS
(MGI:MGI:3640069|PMID:16680193)
GO_REF:0000024
RGD
UniProt
PMID:16680193 GO_REF:0000024, MGI:MGI:3640069 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Tgfb3 transforming growth factor, beta 3 TAS RGD PMID:12183510 RGD:727411 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (MGI:MGI:5543371|PMID:18772315) RGD PMID:18772315 MGI:MGI:5543371 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
regulation of establishment of endothelial barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Plcb1 phospholipase C beta 1 ISO (MGI:MGI:5904576|PMID:27653213) RGD PMID:27653213 MGI:MGI:5904576 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A NOT ISO (PMID:25816133) RGD PMID:25816133 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA
ISO
GO_REF:0000107
UniProtKB:O75116 (PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
UniProtKB:Q13464 (PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Tnf tumor necrosis factor ISO (PMID:25816133) RGD PMID:25816133 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEA
ISO
GO_REF:0000107
(PMID:25816133)
Ensembl
RGD
PMID:25816133 GO_REF:0000107 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Vcl vinculin ISO
IEA
(PMID:26923917)
GO_REF:0000107
RGD
Ensembl
PMID:26923917 GO_REF:0000107 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 ISO (MGI:MGI:5904576|PMID:27653213) RGD PMID:27653213 MGI:MGI:5904576 NCBI chr 5:100,924,621...100,983,412
Ensembl chr 5:100,924,622...100,977,902
JBrowse link
regulation of transcription involved in lymphatic endothelial cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 ISO (PMID:18815287) RGD PMID:18815287 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:18815287) RGD PMID:18815287 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
venous endothelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 ISO (MGI:MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:MGI:4837019 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular developmental process 4459
        cell differentiation 4364
          epithelial cell differentiation 711
            endothelial cell differentiation 125
              blood vessel endothelial cell differentiation + 8
              cardiac endothelial cell differentiation + 6
              endothelial cell development + 85
              endothelial cell fate commitment + 7
              lymphatic endothelial cell differentiation + 7
              negative regulation of endothelial cell differentiation + 11
              positive regulation of endothelial cell differentiation + 11
              regulation of endothelial cell differentiation + 43
Path 2
Term Annotations click to browse term
  biological_process 20028
    developmental process 6827
      anatomical structure development 6269
        tissue development 2099
          epithelium development 1263
            endothelium development 144
              endothelial cell differentiation 125
                blood vessel endothelial cell differentiation + 8
                cardiac endothelial cell differentiation + 6
                endothelial cell development + 85
                endothelial cell fate commitment + 7
                lymphatic endothelial cell differentiation + 7
                negative regulation of endothelial cell differentiation + 11
                positive regulation of endothelial cell differentiation + 11
                regulation of endothelial cell differentiation + 43
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.