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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of T cell differentiation
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Accession:GO:0045581 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of T cell differentiation;   downregulation of T cell differentiation;   negative regulation of T lymphocyte differentiation
 narrow_synonym: inhibition of T cell differentiation
 related_synonym: negative regulation of T cell development


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negative regulation of T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
G Dtx1 deltex E3 ubiquitin ligase 1 JBrowse link 12 41,383,885 41,415,783 RGD:1624291
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:1624291
G Ifnl1 interferon, lambda 1 JBrowse link 1 85,252,103 85,253,635 RGD:1624291
G Nrarp Notch-regulated ankyrin repeat protein JBrowse link 3 2,396,143 2,398,697 RGD:1624291
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:1624291
RGD:1600115
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core-binding factor subunit beta JBrowse link 19 37,127,508 37,171,075 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:1600115
RGD:1624291
G Runx3 RUNX family transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:1624291
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1600115
RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1624291
RGD:1600115
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Tmem131l transmembrane 131 like JBrowse link 2 182,897,332 183,031,273 RGD:1624291
negative regulation of memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgl2 fibrinogen-like 2 JBrowse link 4 10,323,598 10,329,241 RGD:1624291
G Ifnl1 interferon, lambda 1 JBrowse link 1 85,252,103 85,253,635 RGD:1624291
negative regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:1624291
RGD:13792537
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:1600115
RGD:1624291
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1600115
RGD:1624291
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Foxj1 forkhead box J1 JBrowse link 10 105,282,090 105,289,396 RGD:1624291
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Nfkbid NFKB inhibitor delta JBrowse link 1 88,883,816 88,892,543 RGD:1624291
G Zc3h8 zinc finger CCCH type containing 8 JBrowse link 3 121,471,836 121,488,528 RGD:1624291
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:1624291
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
RGD:1600115
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:1624291
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
G Zfp35 zinc finger protein 35 JBrowse link 18 15,883,182 15,898,803 RGD:1624291
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    immune system process 2631
      leukocyte activation 993
        lymphocyte activation 825
          lymphocyte differentiation 389
            T cell differentiation 276
              negative regulation of T cell differentiation 48
                negative regulation of T cell differentiation in thymus + 9
                negative regulation of alpha-beta T cell differentiation + 27
                negative regulation of cytotoxic T cell differentiation 0
                negative regulation of extrathymic T cell differentiation 0
                negative regulation of gamma-delta T cell differentiation 0
                negative regulation of memory T cell differentiation 2
                negative regulation of pro-T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 19439
    developmental process 6674
      anatomical structure development 6139
        multicellular organism development 5606
          system development 5127
            immune system development 1040
              hematopoietic or lymphoid organ development 976
                hemopoiesis 924
                  leukocyte differentiation 571
                    lymphocyte differentiation 389
                      T cell differentiation 276
                        regulation of T cell differentiation 159
                          negative regulation of T cell differentiation 48
                            negative regulation of T cell differentiation in thymus + 9
                            negative regulation of alpha-beta T cell differentiation + 27
                            negative regulation of cytotoxic T cell differentiation 0
                            negative regulation of extrathymic T cell differentiation 0
                            negative regulation of gamma-delta T cell differentiation 0
                            negative regulation of memory T cell differentiation 2
                            negative regulation of pro-T cell differentiation 0
                            negative regulation of regulatory T cell differentiation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.