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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of regulatory T cell differentiation
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Accession:GO:0045589 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulation of regulatory T lymphocyte differentiation;   regulation of suppressor T cell differentiation;   regulation of suppressor T lymphocyte differentiation
 related_synonym: regulation of regulatory T cell development


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regulation of regulatory T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule ISO
IEA
MGI:MGI:96756|MGI:MGI:98725 (MGI:MGI:4946593|PMID:21245484)
GO_REF:0000107
RGD
Ensembl
PMID:21245484 GO_REF:0000107, MGI:MGI:4946593 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Dicer1 dicer 1 ribonuclease III ISO (MGI:MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:MGI:3805722 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Drosha drosha ribonuclease III ISO (MGI:MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:MGI:3805722 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Fanca FA complementation group A ISO
IBA
MGI:MGI:2674094 (MGI:MGI:5569680|PMID:24501220)
PMID:21873635
RGD PMID:24501220, PMID:21873635 MGI:MGI:5569680, RGD:13792537 NCBI chr19:56,067,548...56,126,075
Ensembl chr19:56,067,548...56,126,063
JBrowse link
G Fancd2 FA complementation group D2 ISO
IEA
MGI:MGI:2673422 (MGI:MGI:5569680|PMID:24501220)
GO_REF:0000107
RGD
Ensembl
PMID:24501220 GO_REF:0000107, MGI:MGI:5569680 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Kat2a lysine acetyltransferase 2A ISO (MGI:MGI:5926326|PMID:28424240) RGD PMID:28424240 MGI:MGI:5926326 NCBI chr10:88,611,586...88,619,558
Ensembl chr10:88,611,586...88,619,537
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO MGI:MGI:88327 (MGI:MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:MGI:4946593 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:40,261,990...40,265,757
Ensembl chr12:40,244,081...40,265,757
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO MGI:MGI:88327 (MGI:MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:MGI:4946593 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) ISO (MGI:MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:MGI:5688819 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO
IBA
(PMID:18641304)
PMID:21873635
RGD PMID:18641304, PMID:21873635 RGD:13792537 NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Irf1 interferon regulatory factor 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3803082|PMID:18641303)
Ensembl
UniProt
RGD
PMID:18641303 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3803082 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Lag3 lymphocyte activating 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:3510279|PMID:15485628)
UniProt
RGD
PMID:15485628 GO_REF:0000024, MGI:MGI:3510279 NCBI chr 4:157,425,644...157,433,700
Ensembl chr 4:157,425,644...157,433,467
JBrowse link
G Mdk midkine ISS
ISO
GO_REF:0000024
(PMID:22323540)
UniProt
RGD
PMID:22323540 GO_REF:0000024 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:MGI:3806904 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Tug1 taurine up-regulated 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr14:83,878,757...83,885,791
Ensembl chr14:83,878,295...83,887,584
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 ISO MGI:MGI:1857034|MGI:MGI:2654936|MGI:MGI:3696705 (MGI:MGI:2653673|PMID:12612578), (MGI:MGI:3695768|PMID:16275384), (MGI:MGI:3700459|PMID:16301745), (MGI:MGI:3799419|PMID:18573908) RGD PMID:12612578, PMID:16275384, PMID:16301745, PMID:18573908 MGI:MGI:2653673, MGI:MGI:3695768, MGI:MGI:3700459, MGI:MGI:3799419 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:78,377,228...78,386,683
Ensembl chr 4:78,378,144...78,385,577
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma ISO MGI:MGI:1857455 (MGI:MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:MGI:3662823 NCBI chr  X:71,165,378...71,169,078
Ensembl chr  X:71,162,585...71,169,865
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Lgals9 galectin 9 ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor ISO (PMID:22387553) RGD PMID:22387553 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO (MGI:MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 ISO MGI:MGI:4462559|MGI:MGI:5547539 (MGI:MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:MGI:5544872 NCBI chr19:37,652,383...37,665,333
Ensembl chr19:37,652,969...37,668,019
JBrowse link
G Cd46 CD46 molecule ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO (PMID:22387553) RGD PMID:22387553 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Foxp3 forkhead box P3 ISO MGI:MGI:2654936 (MGI:MGI:2450778|PMID:12522256), (MGI:MGI:3041050|PMID:15100250), (MGI:MGI:3574163|PMID:15780990), (MGI:MGI:3693968|PMID:16769892), (MGI:MGI:3697020|PMID:17028180) RGD PMID:12522256, PMID:15100250, PMID:15780990, PMID:16769892, PMID:17028180 MGI:MGI:2450778, MGI:MGI:3041050, MGI:MGI:3574163, MGI:MGI:3693968, MGI:MGI:3697020 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Il2 interleukin 2 IDA RGD PMID:6233372 RGD:1600097 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lgals9 galectin 9 ISO (MGI:MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:MGI:5688819 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Lilrb2 leukocyte immunoglobulin like receptor B2 ISO (PMID:20448110) RGD PMID:20448110 NCBI chr 1:63,734,135...63,741,986
Ensembl chr 1:63,734,135...63,741,982
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 ISO (PMID:22387553) RGD PMID:22387553 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Mir214 microRNA 214 IMP RGD PMID:30287503 RGD:38549580 NCBI chr13:80,130,905...80,131,014 JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO
IEA
(PMID:22387553)
GO_REF:0000107
RGD
Ensembl
PMID:22387553 GO_REF:0000107 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Sox12 SRY-box transcription factor 12 ISO (MGI:MGI:6203502|PMID:30190287) RGD PMID:30190287 MGI:MGI:6203502 NCBI chr 3:147,864,374...147,865,393
Ensembl chr 3:147,864,374...147,865,393
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO (MGI:MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:MGI:5688819 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Vsir V-set immunoregulatory receptor ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:29,897,543...29,923,381
Ensembl chr20:29,897,594...29,919,998
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    immune system process 2837
      leukocyte activation 1057
        lymphocyte activation 870
          lymphocyte differentiation 407
            T cell differentiation 289
              regulatory T cell differentiation 38
                regulation of regulatory T cell differentiation 34
                  negative regulation of regulatory T cell differentiation + 8
                  positive regulation of regulatory T cell differentiation + 18
                  regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      T cell differentiation 289
                        regulatory T cell differentiation 38
                          regulation of regulatory T cell differentiation 34
                            negative regulation of regulatory T cell differentiation + 8
                            positive regulation of regulatory T cell differentiation + 18
                            regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.