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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of lymphocyte differentiation
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Accession:GO:0045620 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of lymphocyte differentiation;   downregulation of lymphocyte differentiation
 narrow_synonym: inhibition of lymphocyte differentiation
 related_synonym: negative regulation of lymphocyte development


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negative regulation of lymphocyte differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:1624291
negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1624291
RGD:1600115
negative regulation of B cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt3 Fms related receptor tyrosine kinase 3 JBrowse link 12 9,360,439 9,437,004 RGD:1624291
G Hmgb3 high mobility group box 3 JBrowse link 17 36,690,190 36,694,329 RGD:1624291
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:1624291
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:1600115
RGD:1624291
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbfb core-binding factor subunit beta JBrowse link 19 37,127,508 37,171,075 RGD:1624291
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:1624291
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:1600115
RGD:1624291
G Runx3 RUNX family transcription factor 3 JBrowse link 5 153,507,093 153,531,137 RGD:1624291
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Socs1 suppressor of cytokine signaling 1 JBrowse link 10 4,956,795 4,958,472 RGD:1600115
RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1624291
RGD:1600115
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Tmem131l transmembrane 131 like JBrowse link 2 182,897,332 183,031,273 RGD:1624291
negative regulation of memory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgl2 fibrinogen-like 2 JBrowse link 4 10,323,598 10,329,241 RGD:1624291
G Ifnl1 interferon, lambda 1 JBrowse link 1 85,252,103 85,253,635 RGD:1624291
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pglyrp1 peptidoglycan recognition protein 1 JBrowse link 1 79,790,879 79,796,064 RGD:1624291
RGD:1600115
G Pglyrp2 peptidoglycan recognition protein 2 JBrowse link 7 14,426,481 14,435,987 RGD:1624291
G Pglyrp3 peptidoglycan recognition protein 3 JBrowse link 2 191,903,626 192,264,872 RGD:1624291
G Pglyrp4 peptidoglycan recognition protein 4 JBrowse link 2 190,125,655 190,204,230 RGD:1624291
negative regulation of positive thymic T cell selection term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
RGD:1600115
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:1624291
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:1624291
RGD:13792537
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:1600115
RGD:1624291
G Lag3 lymphocyte activating 3 JBrowse link 4 157,425,644 157,433,700 RGD:1600115
RGD:1624291
G Mdk midkine JBrowse link 3 80,841,003 80,843,895 RGD:1600115
RGD:1624291
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cyld CYLD lysine 63 deubiquitinase JBrowse link 19 19,264,984 19,323,817 RGD:1624291
G Dtx1 deltex E3 ubiquitin ligase 1 JBrowse link 12 41,383,885 41,415,783 RGD:1624291
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:1624291
G Ifnl1 interferon, lambda 1 JBrowse link 1 85,252,103 85,253,635 RGD:1624291
G Nrarp Notch-regulated ankyrin repeat protein JBrowse link 3 2,396,143 2,398,697 RGD:1624291
G Prdx2 peroxiredoxin 2 JBrowse link 19 26,084,816 26,090,095 RGD:1624291
RGD:1600115
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1624291
G Foxj1 forkhead box J1 JBrowse link 10 105,282,090 105,289,396 RGD:1624291
G Ihh Indian hedgehog signaling molecule JBrowse link 9 82,208,223 82,214,440 RGD:1624291
G Nfkbid NFKB inhibitor delta JBrowse link 1 88,883,816 88,892,543 RGD:1624291
G Zc3h8 zinc finger CCCH type containing 8 JBrowse link 3 121,471,836 121,488,528 RGD:1624291
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:1624291
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
RGD:1600115
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:1624291
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
G Zfp35 zinc finger protein 35 JBrowse link 18 15,883,182 15,898,803 RGD:1624291
negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19439
    immune system process 2631
      leukocyte activation 993
        lymphocyte activation 825
          lymphocyte differentiation 389
            negative regulation of lymphocyte differentiation 57
              negative regulation of B cell differentiation + 4
              negative regulation of T cell differentiation + 48
              negative regulation of natural killer cell differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 19439
    developmental process 6673
      anatomical structure development 6138
        multicellular organism development 5605
          system development 5126
            animal organ development 3916
              hematopoietic or lymphoid organ development 976
                hemopoiesis 924
                  regulation of hemopoiesis 423
                    negative regulation of hemopoiesis 154
                      negative regulation of leukocyte differentiation 103
                        negative regulation of lymphocyte differentiation 57
                          negative regulation of B cell differentiation + 4
                          negative regulation of T cell differentiation + 48
                          negative regulation of natural killer cell differentiation + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.