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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of T-helper cell differentiation
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Accession:GO:0045623 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of T-helper cell differentiation;   downregulation of T-helper cell differentiation
 narrow_synonym: inhibition of T-helper cell differentiation
 related_synonym: negative regulation of T-helper cell development


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negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link 1 196,942,343 196,967,221 RGD:1624291
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:1624291
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link 13 78,723,028 78,794,663 RGD:1624291
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link 3 21,621,976 21,676,789 RGD:1624291
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:1600115
RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link 2 188,704,989 188,719,674 RGD:1624291
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1600115
RGD:1624291
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase-like 3 JBrowse link 4 113,866,782 113,883,713 RGD:1624291
G Tbx21 T-box transcription factor 21 JBrowse link 10 85,032,799 85,049,331 RGD:1624291
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:1624291
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:1624291
RGD:13792537
RGD:1600115
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Hlx H2.0-like homeobox JBrowse link 13 102,637,967 102,643,376 RGD:1624291
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
G Zfp35 zinc finger protein 35 JBrowse link 18 15,883,182 15,898,803 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19337
    immune system process 2642
      immune effector process 823
        negative regulation of immune effector process 138
          negative regulation of T-helper cell differentiation 19
            negative regulation of T-helper 1 cell differentiation 3
            negative regulation of T-helper 17 cell differentiation + 11
            negative regulation of T-helper 2 cell differentiation 5
Path 2
Term Annotations click to browse term
  biological_process 19337
    developmental process 6638
      anatomical structure development 6107
        multicellular organism development 5579
          system development 5100
            immune system development 1031
              hematopoietic or lymphoid organ development 968
                hemopoiesis 916
                  leukocyte differentiation 567
                    lymphocyte differentiation 386
                      T cell differentiation 274
                        T cell differentiation involved in immune response 72
                          alpha-beta T cell differentiation involved in immune response 65
                            CD4-positive, alpha-beta T cell differentiation involved in immune response 64
                              T-helper cell differentiation 62
                                regulation of T-helper cell differentiation 38
                                  negative regulation of T-helper cell differentiation 19
                                    negative regulation of T-helper 1 cell differentiation 3
                                    negative regulation of T-helper 17 cell differentiation + 11
                                    negative regulation of T-helper 2 cell differentiation 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.