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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of T-helper cell differentiation
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Accession:GO:0045623 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of T-helper cell differentiation;   downregulation of T-helper cell differentiation
 narrow_synonym: inhibition of T-helper cell differentiation
 related_synonym: negative regulation of T-helper cell development


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negative regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004955406 14,053,122 14,123,023 RGD:9068941
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il4r interleukin 4 receptor JBrowse link NW_004955493 5,546,340 5,580,745 RGD:9068941
G Jak3 Janus kinase 3 JBrowse link NW_004955524 3,399,895 3,412,018 RGD:9068941
G Tnfsf4 TNF superfamily member 4 JBrowse link NW_004955406 13,477,077 13,493,309 RGD:9068941
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxp3 forkhead box P3 JBrowse link NW_004955543 731,707 742,606 RGD:9068941
G Il2 interleukin 2 JBrowse link NW_004955428 18,163,010 18,168,157 RGD:9068941
G Rc3h1 ring finger and CCCH-type domains 1 JBrowse link NW_004955406 14,053,122 14,123,023 RGD:9068941
G Rc3h2 ring finger and CCCH-type domains 2 JBrowse link NW_004955419 5,054,288 5,103,926 RGD:9068941
G Smad7 SMAD family member 7 JBrowse link NW_004955402 34,028,184 34,058,949 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004955451 13,315,237 13,317,888 RGD:9068941
G Zbtb7b zinc finger and BTB domain containing 7B JBrowse link NW_004955545 1,504,656 1,519,954 RGD:9068941
G Zc3h12a zinc finger CCCH-type containing 12A JBrowse link NW_004955452 15,306,398 15,314,959 RGD:9068941
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Loxl3 lysyl oxidase like 3 JBrowse link NW_004955424 11,236,415 11,255,801 RGD:9068941
G Tbx21 T-box transcription factor 21 JBrowse link NW_004955451 13,315,237 13,317,888 RGD:9068941
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link NW_004955512 5,686,508 5,703,645 RGD:9068941
G Bcl6 BCL6 transcription repressor JBrowse link NW_004955420 19,998,960 20,021,200 RGD:9068941
G Hlx H2.0 like homeobox JBrowse link NW_004955520 2,937,131 2,941,170 RGD:9068941
G Socs5 suppressor of cytokine signaling 5 JBrowse link NW_004955441 13,593,342 13,657,389 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14568
    immune system process 2499
      immune effector process 1002
        negative regulation of immune effector process 106
          negative regulation of T-helper cell differentiation 16
            negative regulation of T-helper 1 cell differentiation 3
            negative regulation of T-helper 17 cell differentiation + 9
            negative regulation of T-helper 2 cell differentiation 4
Path 2
Term Annotations click to browse term
  biological_process 14568
    developmental process 5902
      anatomical structure development 5470
        multicellular organism development 5017
          system development 4486
            immune system development 922
              hematopoietic or lymphoid organ development 870
                hemopoiesis 832
                  leukocyte differentiation 484
                    lymphocyte differentiation 331
                      T cell differentiation 234
                        T cell differentiation involved in immune response 65
                          alpha-beta T cell differentiation involved in immune response 59
                            CD4-positive, alpha-beta T cell differentiation involved in immune response 58
                              T-helper cell differentiation 56
                                regulation of T-helper cell differentiation 34
                                  negative regulation of T-helper cell differentiation 16
                                    negative regulation of T-helper 1 cell differentiation 3
                                    negative regulation of T-helper 17 cell differentiation + 9
                                    negative regulation of T-helper 2 cell differentiation 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.