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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of T-helper cell differentiation
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Accession:GO:0045624 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of T-helper cell differentiation;   upregulation of T-helper cell differentiation
 narrow_synonym: activation of T-helper cell differentiation;   stimulation of T-helper cell differentiation
 related_synonym: positive regulation of T-helper cell development


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positive regulation of T-helper cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myb myeloblastosis oncogene JBrowse link 10 21,124,930 21,160,984 RGD:2290270
G Shb src homology 2 domain-containing transforming protein B JBrowse link 4 45,423,276 45,530,828 RGD:2290270
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 19 20,373,434 20,390,671 RGD:2290270
G Ccl19 chemokine (C-C motif) ligand 19 JBrowse link 4 42,754,525 42,756,365 RGD:2290270
G Ccr2 chemokine (C-C motif) receptor 2 JBrowse link 9 124,101,918 124,109,140 RGD:2290270
G Ccr7 chemokine (C-C motif) receptor 7 JBrowse link 11 99,144,199 99,155,077 RGD:2290270
G Hlx H2.0-like homeobox JBrowse link 1 184,727,143 184,732,493 RGD:2290270
G Irf1 interferon regulatory factor 1 JBrowse link 11 53,770,014 53,778,374 RGD:2290270
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 JBrowse link 4 16,122,732 16,163,678 RGD:2290270
G Socs5 suppressor of cytokine signaling 5 JBrowse link 17 87,107,278 87,137,647 RGD:2290270
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Malt1 MALT1 paracaspase JBrowse link 18 65,430,939 65,478,888 RGD:2290270
G Mir326 microRNA 326 JBrowse link 7 99,552,269 99,552,363 RGD:2290270
G Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta JBrowse link 7 30,421,731 30,428,749 RGD:2290270
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta JBrowse link 16 55,811,375 55,838,954 RGD:2290270
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:2290270
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il23a interleukin 23, alpha subunit p19 JBrowse link 10 128,296,140 128,298,084 RGD:2290270
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:2290270
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:2290270
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:2290270
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:2290270
G Prkcz protein kinase C, zeta JBrowse link 4 155,260,118 155,361,428 RGD:2290270
G Rara retinoic acid receptor, alpha JBrowse link 11 98,927,800 98,974,942 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23163
    immune system process 2892
      immune effector process 941
        positive regulation of immune effector process 287
          positive regulation of T-helper cell differentiation 22
            positive regulation of T-helper 1 cell differentiation 8
            positive regulation of T-helper 17 cell differentiation + 6
            positive regulation of T-helper 2 cell differentiation 7
Path 2
Term Annotations click to browse term
  biological_process 23163
    developmental process 6947
      anatomical structure development 6420
        multicellular organism development 5888
          system development 5326
            immune system development 1098
              hematopoietic or lymphoid organ development 1034
                hemopoiesis 985
                  leukocyte differentiation 612
                    lymphocyte differentiation 418
                      T cell differentiation 290
                        T cell differentiation involved in immune response 78
                          alpha-beta T cell differentiation involved in immune response 71
                            CD4-positive, alpha-beta T cell differentiation involved in immune response 70
                              T-helper cell differentiation 68
                                regulation of T-helper cell differentiation 40
                                  positive regulation of T-helper cell differentiation 22
                                    positive regulation of T-helper 1 cell differentiation 8
                                    positive regulation of T-helper 17 cell differentiation + 6
                                    positive regulation of T-helper 2 cell differentiation 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.