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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of T-helper 2 cell differentiation
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Accession:GO:0045630 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: up regulation of T-helper 2 cell differentiation;   upregulation of T-helper 2 cell differentiation
 narrow_synonym: activation of T-helper 2 cell differentiation;   stimulation of T-helper 2 cell differentiation
 related_synonym: positive regulation of T-helper 2 cell development


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positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 ISO
IEA
(MGI:MGI:3608083|PMID:12829194)
GO_REF:0000107
RGD
Ensembl
PMID:12829194 GO_REF:0000107, MGI:MGI:3608083 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il4r interleukin 4 receptor ISO MGI:MGI:96109 (MGI:MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:MGI:3761239 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il6 interleukin 6 ISO (MGI:MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:MGI:2450484 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO (MGI:MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:MGI:5689221 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Prkcz protein kinase C, zeta ISO
ISS
(MGI:MGI:3584076|PMID:15987782)
GO_REF:0000024
RGD
UniProt
PMID:15987782 GO_REF:0000024, MGI:MGI:3584076 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rara retinoic acid receptor, alpha ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:MGI:4943387 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    immune system process 2837
      immune response 1748
        type 2 immune response 39
          positive regulation of type 2 immune response 15
            positive regulation of T-helper 2 cell differentiation 7
Path 2
Term Annotations click to browse term
  biological_process 20014
    developmental process 6812
      anatomical structure development 6256
        multicellular organism development 5735
          system development 5272
            immune system development 1073
              hematopoietic or lymphoid organ development 1008
                hemopoiesis 956
                  leukocyte differentiation 595
                    lymphocyte differentiation 407
                      T cell differentiation 289
                        T cell differentiation involved in immune response 75
                          alpha-beta T cell differentiation involved in immune response 67
                            CD4-positive, alpha-beta T cell differentiation involved in immune response 66
                              T-helper cell differentiation 64
                                regulation of T-helper cell differentiation 38
                                  positive regulation of T-helper cell differentiation 19
                                    positive regulation of T-helper 2 cell differentiation 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.