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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of DNA repair
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Accession:GO:0045738 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
Synonyms:exact_synonym: down regulation of DNA repair;   downregulation of DNA repair
 narrow_synonym: inhibition of DNA repair


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negative regulation of DNA repair term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rps3 ribosomal protein S3 ISO (PMID:17049931) RGD PMID:17049931 NCBI chr 1:164,435,868...164,441,167
Ensembl chr 1:164,435,878...164,441,167
JBrowse link
negative regulation of double-strand break repair term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 ISO
IBA
ISS
(PMID:20725033)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:20725033, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:222,451,674...222,459,952
Ensembl chr 1:222,451,674...222,459,952
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
JBrowse link
G Rnf169 ring finger protein 169 ISO (PMID:22492721), (PMID:22733822), (PMID:22742833) RGD PMID:22492721, PMID:22733822, PMID:22742833 NCBI chr 1:164,917,069...164,978,061
Ensembl chr 1:164,922,080...164,977,633
JBrowse link
G Trip12 thyroid hormone receptor interactor 12 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692 GO_REF:0000024, GO_REF:0000107 NCBI chr 9:92,305,059...92,435,388
Ensembl chr 9:92,305,051...92,435,365
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:22884692)
Ensembl
UniProt
RGD
PMID:22884692 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cgas cyclic GMP-AMP synthase ISO
IBA
(PMID:30356214)
PMID:21873635
(MGI:MGI:6241455|PMID:30356214)
RGD PMID:30356214, PMID:21873635 MGI:MGI:6241455, RGD:13792537 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Fancb FA complementation group B ISO
IBA
MGI:MGI:2156841 (MGI:MGI:5648586|PMID:25520194)
PMID:21873635
RGD PMID:25520194, PMID:21873635 MGI:MGI:5648586, RGD:13792537 NCBI chr  X:31,124,018...31,140,790
Ensembl chr  X:31,124,018...31,140,711
JBrowse link
G Fbh1 F-box DNA helicase 1 ISO (PMID:19736316)
(MGI:MGI:5566975|PMID:24108124)
RGD PMID:19736316, PMID:24108124 MGI:MGI:5566975 NCBI chr17:70,399,093...70,437,151
Ensembl chr17:70,399,049...70,437,144
JBrowse link
G Helb DNA helicase B ISO
IBA
(PMID:26774285)
PMID:21873635
(MGI:MGI:5766842|PMID:26774285)
RGD PMID:26774285, PMID:21873635 MGI:MGI:5766842, RGD:13792537 NCBI chr 7:64,860,641...64,888,146
Ensembl chr 7:64,860,666...64,887,448
JBrowse link
G Klhl15 kelch-like family member 15 ISO (PMID:27561354) RGD PMID:27561354 NCBI chr  X:63,342,277...63,390,915
Ensembl chr  X:63,343,546...63,389,989
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255
JBrowse link
G Parpbp PARP1 binding protein ISO
IBA
IEA
ISS
(PMID:22153967)
PMID:21873635
GO_REF:0000002
GO_REF:0000024
RGD
InterPro
UniProt
PMID:22153967, PMID:21873635 GO_REF:0000002, GO_REF:0000024, RGD:13792537 NCBI chr 7:28,654,707...28,724,412
Ensembl chr 7:28,654,707...28,715,224
JBrowse link
G Polq DNA polymerase theta ISO (PMID:25642963)
(MGI:MGI:5621198|PMID:25642960)
RGD PMID:25642960, PMID:25642963 MGI:MGI:5621198 NCBI chr11:66,585,860...66,695,369
Ensembl chr11:66,585,881...66,695,353
JBrowse link
G Radx RPA1 related single stranded DNA binding protein, X-linked ISO
ISS
(PMID:28735897)
GO_REF:0000024
RGD
UniProt
PMID:28735897 GO_REF:0000024 NCBI chr  X:110,670,037...110,782,420
Ensembl chr  X:110,670,119...110,782,284
JBrowse link
G Recql5 RecQ like helicase 5 ISO MGI:MGI:2448558 (MGI:MGI:5648586|PMID:25520194) RGD PMID:25520194 MGI:MGI:5648586 NCBI chr10:104,443,735...104,482,889
Ensembl chr10:104,443,736...104,482,838
JBrowse link
G Rif1 replication timing regulatory factor 1 ISO (PMID:23333306)
(MGI:MGI:5468037|PMID:23306437), (MGI:MGI:5476381|PMID:23333305)
RGD PMID:23306437, PMID:23333305, PMID:23333306 MGI:MGI:5468037, MGI:MGI:5476381 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
JBrowse link
G Rmi2 RecQ mediated genome instability 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:4,904,458...4,910,339
Ensembl chr10:4,905,210...4,910,305
JBrowse link
G Shld1 shieldin complex subunit 1 ISO
IBA
(PMID:29656893)
PMID:21873635
RGD PMID:29656893, PMID:21873635 RGD:13792537 NCBI chr 3:125,318,682...125,396,705
Ensembl chr 3:125,320,680...125,396,821
JBrowse link
G Shld2 shieldin complex subunit 2 ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:10,570,307...10,661,528
Ensembl chr16:10,570,314...10,661,528
JBrowse link
G Smchd1 structural maintenance of chromosomes flexible hinge domain containing 1 ISO (PMID:25294876) RGD PMID:25294876 NCBI chr 9:119,675,750...119,818,620
Ensembl chr 9:119,676,628...119,818,310
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO (PMID:23333306), (PMID:23345425)
(MGI:MGI:5476381|PMID:23333305), (MGI:MGI:5887194|PMID:20362325)
RGD PMID:20362325, PMID:23333305, PMID:23333306, PMID:23345425 MGI:MGI:5476381, MGI:MGI:5887194 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
G Ubqln4 ubiquilin 4 ISO (PMID:30612738) RGD PMID:30612738 NCBI chr 2:187,915,701...187,931,035
Ensembl chr 2:187,915,751...187,931,035
JBrowse link
negative regulation of double-strand break repair via nonhomologous end joining term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aunip aurora kinase A and ninein interacting protein ISO
ISS
(PMID:29042561)
GO_REF:0000024
RGD
UniProt
PMID:29042561 GO_REF:0000024 NCBI chr 5:152,721,799...152,734,577
Ensembl chr 5:152,721,940...152,734,572
JBrowse link
G Cyren cell cycle regulator of NHEJ ISO
ISS
(PMID:28959974)
GO_REF:0000024
RGD
UniProt
PMID:28959974 GO_REF:0000024 NCBI chr 4:62,391,770...62,397,162
Ensembl chr 4:62,391,770...62,396,035
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor ISO (PMID:25820262) RGD PMID:25820262 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:19549901)
GO_REF:0000024
RGD
UniProt
PMID:19549901 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Hsf1 heat shock transcription factor 1 ISO (PMID:26359349) RGD PMID:26359349 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 ISO (PMID:28241136) RGD PMID:28241136 NCBI chr10:10,829,866...10,831,782
Ensembl chr10:10,829,867...10,831,782
JBrowse link
negative regulation of double-strand break repair via single-strand annealing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ogg1 8-oxoguanine DNA glycosylase ISO (PMID:19506022) RGD PMID:19506022 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      negative regulation of cellular process 5144
        negative regulation of response to DNA damage stimulus 77
          negative regulation of DNA repair 31
            negative regulation of base-excision repair 0
            negative regulation of double-strand break repair + 30
            negative regulation of error-prone translesion synthesis 0
            negative regulation of mismatch repair 0
            negative regulation of single strand break repair + 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular aromatic compound metabolic process 5708
          nucleobase-containing compound metabolic process 5483
            nucleic acid metabolic process 4980
              DNA metabolic process 919
                DNA repair 482
                  regulation of DNA repair 130
                    negative regulation of DNA repair 31
                      negative regulation of base-excision repair 0
                      negative regulation of double-strand break repair + 30
                      negative regulation of error-prone translesion synthesis 0
                      negative regulation of mismatch repair 0
                      negative regulation of single strand break repair + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.