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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:1624291
RGD:1600115
G Cry1 cryptochrome circadian regulator 1 JBrowse link 7 24,534,593 24,634,098 RGD:1624291
RGD:1600115
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:632163
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:632163
G Klk14 kallikrein related-peptidase 14 JBrowse link 1 99,616,153 99,621,425 RGD:1624291
RGD:1600115
G Mgrn1 mahogunin ring finger 1 JBrowse link 10 10,832,573 10,881,999 RGD:1600115
RGD:13792537
RGD:1624291
G Plek pleckstrin JBrowse link 14 100,151,518 100,184,192 RGD:1624291
RGD:1600115
G Rgs12 regulator of G-protein signaling 12 JBrowse link 14 80,975,239 81,069,519 RGD:69959
G Rgs13 regulator of G-protein signaling 13 JBrowse link 13 60,970,172 61,004,260 RGD:1624291
RGD:1600115
G Rgs14 regulator of G-protein signaling 14 JBrowse link 17 9,777,925 9,792,007 RGD:1600115
RGD:1624291
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:633858
RGD:1624291
RGD:7207364
G Rgs4 regulator of G-protein signaling 4 JBrowse link 13 88,054,817 88,061,108 RGD:7207364
RGD:7207376
G Rpgrip1l Rpgrip1-like JBrowse link 19 17,115,266 17,208,055 RGD:1624291
RGD:1600115
G Rph3al rabphilin 3A-like (without C2 domains) JBrowse link 10 63,989,556 64,140,584 RGD:1624291
RGD:1600115
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta JBrowse link 3 160,391,108 160,399,931 RGD:1624291
RGD:1600115
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gipr gastric inhibitory polypeptide receptor JBrowse link 1 80,063,047 80,073,223 RGD:2312614
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:632163
RGD:13792694
RGD:1624291
RGD:1600115
RGD:8553863
RGD:7242040
G Grk3 G protein-coupled receptor kinase 3 JBrowse link 12 49,626,871 49,750,389 RGD:632163
RGD:5685621
RGD:5685022
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1598508
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:61618
RGD:13792694
G Grk6 G protein-coupled receptor kinase 6 JBrowse link 17 9,705,917 9,721,921 RGD:1299124
RGD:7242040
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:728711
G Ly6g6e lymphocyte antigen 6 family member G6E JBrowse link 20 5,063,148 5,069,032 RGD:1624291
RGD:13792537
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:9850278
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:1624291
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:5509896
RGD:1624291
G protein-coupled receptor catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn2 beclin 2 JBrowse link 13 93,971,720 93,974,467 RGD:1624291
RGD:1600115
G Gprasp1 G protein-coupled receptor associated sorting protein 1 JBrowse link X 106,306,795 106,313,904 RGD:1624291
RGD:1600115
G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:1624291
RGD:1600115
G Arr3 arrestin 3 JBrowse link X 70,438,590 70,452,140 RGD:13792537
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
RGD:13792537
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:1624291
RGD:13792537
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Dnm1 dynamin 1 JBrowse link 3 11,338,081 11,382,043 RGD:9685157
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685157
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1581465
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:1581465
RGD:1624291
G Grk4 G protein-coupled receptor kinase 4 JBrowse link 14 81,261,708 81,339,516 RGD:1304268
G Htr1b 5-hydroxytryptamine receptor 1B JBrowse link 8 89,113,984 89,130,830 RGD:1624291
RGD:1600115
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:1600115
RGD:1624291
G Pld2 phospholipase D2 JBrowse link 10 57,161,921 57,181,148 RGD:1624291
G Sag S-antigen visual arrestin JBrowse link 9 94,926,901 94,972,162 RGD:13792537
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:1624291
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ada adenosine deaminase JBrowse link 3 160,115,840 160,139,947 RGD:1624291
RGD:13792537
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arrdc3 arrestin domain containing 3 JBrowse link 2 8,732,907 8,745,445 RGD:1624291
RGD:1600115
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 JBrowse link 13 50,091,644 50,153,808 RGD:1600115
RGD:1624291
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:13508593
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:1624291
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplp1 amyloid beta precursor like protein 1 JBrowse link 1 88,897,525 88,908,750 RGD:1624291
RGD:1600115
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:13792694
G Grk5 G protein-coupled receptor kinase 5 JBrowse link 1 282,265,371 282,467,842 RGD:13792694
G Mrap melanocortin 2 receptor accessory protein JBrowse link 11 30,904,733 30,915,225 RGD:1624291
G Mrap2 melanocortin 2 receptor accessory protein 2 JBrowse link 8 94,801,336 94,858,192 RGD:1624291
RGD:1600115
G Oprl1 opioid related nociceptin receptor 1 JBrowse link 3 177,223,779 177,231,663 RGD:9835006
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:9835006
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:9850263
G Sstr4 somatostatin receptor 4 JBrowse link 3 142,739,781 142,741,644 RGD:2325010
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:1624291
RGD:1600115
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Necab2 N-terminal EF-hand calcium binding protein 2 JBrowse link 19 52,086,325 52,112,633 RGD:1624291
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:1624291
RGD:1600115
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bicd1 BICD cargo adaptor 1 JBrowse link 4 184,018,845 184,167,628 RGD:8693367
RGD:1624291
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1600115
RGD:1624291
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
RGD:1600115
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:1624291
RGD:1600115
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apln apelin JBrowse link X 134,856,719 134,866,210 RGD:12907555
RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplnr apelin receptor JBrowse link 3 72,540,538 72,544,183 RGD:1624291
RGD:1600115
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344
prostaglandin receptor internalization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:10043344
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rgs12 regulator of G-protein signaling 12 JBrowse link 14 80,975,239 81,069,519 RGD:7207399

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      signal transduction 6597
        G protein-coupled receptor signaling pathway 2395
          negative regulation of G protein-coupled receptor signaling pathway 60
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 30
            negative regulation by symbiont of host G protein-coupled receptor signal transduction + 0
            negative regulation of G protein-coupled receptor signaling pathway in response to host + 0
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 18166
    biological regulation 12793
      regulation of biological process 12128
        regulation of cellular process 11458
          regulation of cell communication 3413
            negative regulation of cell communication 1340
              negative regulation of signal transduction 1202
                negative regulation of G protein-coupled receptor signaling pathway 60
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 30
                  negative regulation by symbiont of host G protein-coupled receptor signal transduction + 0
                  negative regulation of G protein-coupled receptor signaling pathway in response to host + 0
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.