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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO
IEA
(PMID:10734056)
GO_REF:0000107
RGD
Ensembl
PMID:10734056 GO_REF:0000107 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO
ISS
(MGI:MGI:5567906|PMID:20852621)
GO_REF:0000024
RGD
UniProt
PMID:20852621 GO_REF:0000024, MGI:MGI:5567906 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IDA RGD PMID:1403099 RGD:632163 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IC RGD PMID:1403099 RGD:632163 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Klk14 kallikrein related-peptidase 14 ISO (PMID:16885167) RGD PMID:16885167 NCBI chr 1:99,616,153...99,621,425
Ensembl chr 1:99,616,447...99,621,037
JBrowse link
G Mgrn1 mahogunin ring finger 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:19737927)
Ensembl
UniProt
RGD
PMID:19737927, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr10:10,832,573...10,881,999
Ensembl chr10:10,833,519...10,881,977
JBrowse link
G Plek pleckstrin ISO (PMID:7782310) RGD PMID:7782310 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link
G Rgs12 regulator of G-protein signaling 12 IEP RGD PMID:9651375 RGD:69959 NCBI chr14:80,975,239...81,069,519
Ensembl chr14:80,975,322...81,053,906
JBrowse link
G Rgs13 regulator of G-protein signaling 13 ISO (MGI:MGI:2385407|PMID:12193720) RGD PMID:12193720 MGI:MGI:2385407 NCBI chr13:60,970,172...61,004,260
Ensembl chr13:60,970,247...61,003,744
JBrowse link
G Rgs14 regulator of G-protein signaling 14 ISS
ISO
GO_REF:0000024
(MGI:MGI:5009199|PMID:10926822)
UniProt
RGD
PMID:10926822 GO_REF:0000024, MGI:MGI:5009199 NCBI chr17:9,777,925...9,792,007
Ensembl chr17:9,777,842...9,792,007
JBrowse link
G Rgs2 regulator of G-protein signaling 2 IEP
ISO
IMP
(MGI:MGI:3836877|PMID:19127022) RGD PMID:19127022, PMID:11968023, PMID:21798518 MGI:MGI:3836877, RGD:633858, RGD:7207364 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:21798518, PMID:9918533 RGD:7207364, RGD:7207376 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rnf157 ring finger protein 157 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:105,291,148...105,368,316
Ensembl chr10:105,293,490...105,368,242
JBrowse link
G Rpgrip1l Rpgrip1-like ISO (PMID:19464661) RGD PMID:19464661 NCBI chr19:17,115,266...17,208,055
Ensembl chr19:17,115,412...17,208,055
JBrowse link
G Rph3al rabphilin 3A-like (without C2 domains) ISO MGI:MGI:3051976 (MGI:MGI:3044444|PMID:15159548) RGD PMID:15159548 MGI:MGI:3044444 NCBI chr10:63,989,556...64,140,584
Ensembl chr10:63,989,644...64,108,554
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta ISO
ISS
(PMID:21224381)
GO_REF:0000024
RGD
UniProt
PMID:21224381 GO_REF:0000024 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:80,063,047...80,073,223
Ensembl chr 1:80,063,049...80,073,223
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IC
IMP
ISO
IEA
IDA
MGI:MGI:2180127|MGI:MGI:87937 (MGI:MGI:1337704|PMID:10338466), (MGI:MGI:84440|PMID:7761854)
GO_REF:0000107
PMID:18223549
RGD
Ensembl
PMID:7761854, PMID:10338466, PMID:1403099, PMID:30075183, PMID:18223549, PMID:17908240 GO_REF:0000107, MGI:MGI:1337704, MGI:MGI:84440, RGD:632163, RGD:13792694, RGD:8553863, RGD:7242040 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IC
IMP
IDA
RGD PMID:1403099, PMID:8381966, PMID:20837135 RGD:632163, RGD:5685621, RGD:5685022 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:81,261,708...81,339,516
Ensembl chr14:81,265,672...81,339,526
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574, PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Grm5 glutamate metabotropic receptor 5 IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E ISO
IBA
(MGI:MGI:5694852|PMID:26276394)
PMID:21873635
RGD PMID:26276394, PMID:21873635 MGI:MGI:5694852, RGD:13792537 NCBI chr20:5,063,148...5,069,032
Ensembl chr20:5,067,330...5,068,624
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO
ISS
(PMID:15123695)
GO_REF:0000024
RGD
HGNC
PMID:15123695 GO_REF:0000024 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 NOT ISO (PMID:15123695) RGD PMID:15123695 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Arrb2 arrestin, beta 2 IMP
ISO
(PMID:12582207) RGD PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn2 beclin 2 ISO UniProtKB:Q5JY77 (PMID:23954414)
MGI:MGI:5550535 (MGI:MGI:5528919|PMID:23954414)
RGD PMID:23954414 MGI:MGI:5528919 NCBI chr13:93,971,720...93,974,467
Ensembl chr13:93,972,426...93,974,410
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 ISO
IEA
ISS
UniProtKB:A8MW95 (PMID:23954414)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23954414 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:106,306,795...106,313,904
Ensembl chr  X:106,306,795...106,313,853
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Arr3 arrestin 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:70,438,590...70,452,140
Ensembl chr  X:70,438,617...70,452,067
JBrowse link
G Arrb1 arrestin, beta 1 ISO
IBA
(PMID:10521508), (PMID:12582207)
PMID:21873635
RGD PMID:10521508, PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 ISO
IBA
(PMID:10644702), (PMID:12582207)
PMID:21873635
RGD PMID:10644702, PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:11,338,081...11,382,043
Ensembl chr 3:11,338,083...11,382,043
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:22,458,869...22,540,649
Ensembl chr 8:22,458,899...22,540,524
JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 IDA
ISO
(PMID:18424554) RGD PMID:18424554, PMID:14617818 RGD:1581465 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:81,261,708...81,339,516
Ensembl chr14:81,265,672...81,339,526
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO (MGI:MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:MGI:4821070 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B IEA
ISO
GO_REF:0000107
(MGI:MGI:4821070|PMID:17325130)
Ensembl
RGD
PMID:17325130 GO_REF:0000107, MGI:MGI:4821070 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Pld2 phospholipase D2 ISO (MGI:MGI:3042801|PMID:14718562) RGD PMID:14718562 MGI:MGI:3042801 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Sag S-antigen visual arrestin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:94,926,901...94,972,162
Ensembl chr 9:94,928,489...94,972,027
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO (MGI:MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:MGI:4352609 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO
IBA
(PMID:16670267)
PMID:21873635
RGD PMID:16670267, PMID:21873635 RGD:13792537 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 ISO MGI:MGI:3877613 (MGI:MGI:5302794|PMID:21982743) RGD PMID:21982743 MGI:MGI:5302794 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) RGD PMID:17242280 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Gnai2 G protein subunit alpha i2 IDA RGD PMID:12631586 RGD:13508593 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Pde4b phosphodiesterase 4B ISO (MGI:MGI:5286798|PMID:21670503) RGD PMID:21670503 MGI:MGI:5286798 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp1 amyloid beta precursor like protein 1 ISO (PMID:16531006) RGD PMID:16531006 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:30075183 RGD:13792694 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:30075183 RGD:13792694 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO (PMID:19329486) RGD PMID:19329486 NCBI chr11:30,904,733...30,915,225
Ensembl chr11:30,904,733...30,915,225
JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO (PMID:19329486) RGD PMID:19329486 NCBI chr 8:94,801,336...94,858,192
Ensembl chr 8:94,801,336...94,857,443
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IDA RGD PMID:15748148 RGD:9835006 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Oprm1 opioid receptor, mu 1 IDA RGD PMID:15748148 RGD:9835006 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9013884 RGD:9850263 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Sstr4 somatostatin receptor 4 IDA RGD PMID:8175684 RGD:2325010 NCBI chr 3:142,739,781...142,741,644
Ensembl chr 3:142,739,781...142,741,644
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G-protein signaling 2 ISO (MGI:MGI:5009116|PMID:21291891) RGD PMID:21291891 MGI:MGI:5009116 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:52,086,325...52,112,633
Ensembl chr19:52,086,325...52,112,629
JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:18,723,313...18,726,732
Ensembl chr  X:18,723,341...18,726,732
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 IMP
ISO
PMID:20164183
(MGI:MGI:4887309|PMID:20164183)
RGD PMID:20164183, PMID:20164183 MGI:MGI:4887309, RGD:8693367 NCBI chr 4:184,018,845...184,167,628
Ensembl chr 4:184,019,087...184,165,540
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase IEA
ISO
GO_REF:0000107
(PMID:25198505)
Ensembl
RGD
PMID:25198505 GO_REF:0000107 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Snca synuclein alpha ISO (PMID:12239163) RGD PMID:12239163 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Stmn1 stathmin 1 ISO (PMID:25198505) RGD PMID:25198505 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apln apelin IDA
ISO
PMID:11359874
(MGI:MGI:5902690|PMID:11359874)
(PMID:11359874)
RGD PMID:11359874, PMID:11359874 MGI:MGI:5902690, RGD:12907555 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G App amyloid beta precursor protein ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor ISO
ISS
(PMID:25639753)
GO_REF:0000024
RGD
UniProt
PMID:25639753 GO_REF:0000024 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs12 regulator of G-protein signaling 12 IDA RGD PMID:11130074 RGD:7207399 NCBI chr14:80,975,239...81,069,519
Ensembl chr14:80,975,322...81,053,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      signal transduction 7011
        G protein-coupled receptor signaling pathway 2509
          negative regulation of G protein-coupled receptor signaling pathway 61
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 30
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          regulation of cell communication 3481
            negative regulation of cell communication 1371
              negative regulation of signal transduction 1235
                negative regulation of G protein-coupled receptor signaling pathway 61
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 30
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.