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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172
JBrowse link
G CRY1 cryptochrome circadian regulator 1 ISO (MGI:5567906|PMID:20852621) UniProt PMID:20852621 MGI:5567906 NCBI chr12:104,558,874...104,658,833
Ensembl chr12:107,954,262...108,052,484
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G KLK14 kallikrein related peptidase 14 ISO (PMID:16885167) UniProtKB PMID:16885167 NCBI chr19:48,044,789...48,050,854
Ensembl chr19:56,933,454...56,937,902
JBrowse link
G MGRN1 mahogunin ring finger 1 ISO (PMID:19737927) UniProtKB PMID:19737927 NCBI chr16:3,550,352...3,615,693
Ensembl chr16:4,740,763...4,782,638
JBrowse link
G PLEK pleckstrin ISO (PMID:7782310) BHF-UCL PMID:7782310 NCBI chr2A:68,414,281...68,446,647
Ensembl chr2A:69,537,983...69,570,393
JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 4:3,439,030...3,589,026
Ensembl chr 4:3,444,570...3,573,712
JBrowse link
G RGS13 regulator of G protein signaling 13 ISO (MGI:2385407|PMID:12193720) MGI PMID:12193720 MGI:2385407 NCBI chr 1:168,073,338...168,124,215
Ensembl chr 1:172,395,240...172,419,307
JBrowse link
G RGS14 regulator of G protein signaling 14 ISO (MGI:5009199|PMID:10926822) UniProt PMID:10926822 MGI:5009199 NCBI chr 5:172,659,323...172,674,084
Ensembl chr 5:179,721,876...179,739,453
JBrowse link
G RGS2 regulator of G protein signaling 2 ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023, PMID:19127022, PMID:21798518 MGI:3836877, RGD:633858, RGD:7207364 NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955
JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:9918533, PMID:21798518 RGD:7207364, RGD:7207376 NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225
JBrowse link
G RPGRIP1L RPGRIP1 like ISO (PMID:19464661) UniProtKB PMID:19464661 NCBI chr16:33,836,361...33,939,265
Ensembl chr16:52,920,796...53,023,174
JBrowse link
G RPH3AL rabphilin 3A like (without C2 domains) ISO (MGI:3044444|PMID:15159548) MGI PMID:15159548 MGI:3044444 NCBI chr17:90,816...293,651
Ensembl chr17:146,155...283,278
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO (PMID:21224381) UniProtKB PMID:21224381 NCBI chr20:41,216,071...41,238,893
Ensembl chr20:42,309,155...42,331,695
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr19:42,673,553...42,688,059
Ensembl chr19:51,213,090...51,225,293
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO (MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
PMID:18223549
RGD
MGI
BHF-UCL
PMID:7761854, PMID:10338466, PMID:17908240, PMID:18223549, PMID:30075183 MGI:1337704, MGI:84440, RGD:13792694, RGD:7242040, RGD:8553863 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966, PMID:20837135 RGD:5685022, RGD:5685621 NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574, PMID:30075183 RGD:13792694, RGD:61618 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr 5:172,704,978...172,744,907
Ensembl chr 5:179,790,662...179,807,410
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:83,514,978...84,077,650
Ensembl chr11:87,107,788...87,868,953
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 ISO (PMID:15123695) HGNC PMID:15123695 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chr 8:37,263,730...37,267,475 JBrowse link
G ARRB2 arrestin beta 2 ISO (PMID:12582207) UniProtKB
RGD
PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 ISO (PMID:23954414)
(MGI:5528919|PMID:23954414)
UniProtKB
MGI
PMID:23954414 MGI:5528919 NCBI chr 1:217,520,628...217,522,177
Ensembl chr 1:222,499,853...222,501,148
JBrowse link
G GPRASP1 G protein-coupled receptor associated sorting protein 1 ISO (PMID:23954414) UniProtKB
MGI
PMID:23954414 NCBI chr  X:91,823,855...91,881,439 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842
JBrowse link
G ARRB1 arrestin beta 1 ISO (PMID:10521508), (PMID:12582207) UniProtKB PMID:10521508, PMID:12582207 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155
JBrowse link
G ARRB2 arrestin beta 2 ISO (PMID:10644702)
(PMID:12582207)
UniProtKB PMID:10644702, PMID:12582207 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
JBrowse link
G CALCA calcitonin related polypeptide alpha ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267
JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:99,324,385...99,376,262
Ensembl chr 9:128,004,508...128,044,690
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr19:10,272,172...10,386,032
Ensembl chr19:10,933,672...11,106,478
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935
JBrowse link
G DRD3 dopamine receptor D3 ISO (PMID:18424554) BHF-UCL
RGD
PMID:14617818, PMID:18424554 RGD:1581465 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr2B:118,362,719...118,381,253
Ensembl chr2B:237,153,709...237,170,591
JBrowse link
G PLD2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO (PMID:16670267) UniProtKB PMID:16670267 NCBI chr20:40,950,238...40,982,481
Ensembl chr20:42,044,613...42,076,868
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRDC3 arrestin domain containing 3 ISO (MGI:5302794|PMID:21982743) MGI PMID:21982743 MGI:5302794 NCBI chr 5:23,991,325...24,005,913
Ensembl chr 5:24,126,427...24,140,858
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) BHF-UCL PMID:17242280 NCBI chr 1:179,231,712...179,348,759
Ensembl chr 1:183,580,773...183,639,882
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chr 3:50,154,731...50,187,948
Ensembl chr 3:51,398,981...51,421,988
JBrowse link
G PDE4B phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chr 1:65,038,120...65,620,764
Ensembl chr 1:67,045,911...67,506,291
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLP1 amyloid beta precursor like protein 1 ISO (PMID:16531006) BHF-UCL PMID:16531006 NCBI chr19:32,786,362...32,797,728
Ensembl chr19:41,534,569...41,545,906
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809
JBrowse link
G MRAP melanocortin 2 receptor accessory protein ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr21:18,665,550...18,679,537
Ensembl chr21:32,047,269...32,063,104
JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr 6:81,914,767...82,041,579
Ensembl chr 6:85,199,558...85,257,251
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 Ensembl chr20:62,004,176...62,017,866 JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr 6:151,827,323...151,937,658
Ensembl chr 6:156,517,661...157,088,251
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
G SSTR4 somatostatin receptor 4 ISO RGD PMID:8175684 RGD:2325010 NCBI chr20:22,982,009...22,986,058
Ensembl chr20:23,333,320...23,334,766
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 ISO (MGI:5009116|PMID:21291891) BHF-UCL PMID:21291891 MGI:5009116 NCBI chr 1:168,273,112...168,276,348
Ensembl chr 1:172,566,701...172,569,955
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) UniProtKB PMID:17689978 NCBI chr16:64,636,198...64,670,019
Ensembl chr16:83,983,626...84,013,436
JBrowse link
G UBQLN2 ubiquilin 2 ISO (PMID:18199683) UniProtKB PMID:18199683 NCBI chr  X:48,829,844...48,835,040
Ensembl chr  X:56,981,985...56,983,859
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BICD1 BICD cargo adaptor 1 ISO PMID:20164183
(MGI:4887309|PMID:20164183)
BHF-UCL PMID:20164183 MGI:4887309, RGD:8693367 NCBI chr12:53,838,986...54,118,340
Ensembl chr12:56,443,504...56,713,377
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase ISO (PMID:25198505) CAFA PMID:25198505 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159
JBrowse link
G SNCA synuclein alpha ISO (PMID:12239163) UniProtKB PMID:12239163 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600
JBrowse link
G STMN1 stathmin 1 ISO (PMID:25198505) CAFA PMID:25198505 NCBI chr 1:25,159,241...25,165,535
Ensembl chr 1:26,208,731...26,230,925
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chr 4:157,125,485...157,145,999
Ensembl chr 4:169,176,910...169,195,553
JBrowse link
G APLN apelin ISO (PMID:11359874)
(MGI:5902690|PMID:11359874)
UniProtKB
UniProt
PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APP amyloid beta precursor protein ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chr11:52,475,088...52,479,102
Ensembl chr 3:159,967,360...159,968,502
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chr 4:3,439,030...3,589,026
Ensembl chr 4:3,444,570...3,573,712
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12567
    cellular process 11672
      signal transduction 3814
        G protein-coupled receptor signaling pathway 470
          negative regulation of G protein-coupled receptor signaling pathway 59
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 28
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 12567
    biological regulation 9173
      regulation of biological process 8677
        regulation of cellular process 8203
          regulation of cell communication 2966
            negative regulation of cell communication 1285
              negative regulation of signal transduction 1154
                negative regulation of G protein-coupled receptor signaling pathway 59
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 28
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.