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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:5567906|PMID:20852621) UniProt PMID:20852621 MGI:5567906 NCBI chrNW_004955405:40,878,227...40,941,664
Ensembl chrNW_004955405:40,874,322...40,941,664
JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Mgrn1 mahogunin ring finger 1 ISO (PMID:19737927) UniProtKB PMID:19737927 NCBI chrNW_004955442:12,780,795...12,823,716
Ensembl chrNW_004955442:12,781,539...12,824,222
JBrowse link
G Plek pleckstrin ISO (PMID:7782310) BHF-UCL PMID:7782310 NCBI chrNW_004955424:16,494,052...16,524,790
Ensembl chrNW_004955424:16,493,960...16,524,998
JBrowse link
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chrNW_004955514:2,081,575...2,154,414
Ensembl chrNW_004955514:2,088,354...2,154,191
JBrowse link
G Rgs13 regulator of G protein signaling 13 ISO (MGI:2385407|PMID:12193720) MGI PMID:12193720 MGI:2385407 NCBI chrNW_004955406:30,111,770...30,134,605
Ensembl chrNW_004955406:30,111,760...30,135,283
JBrowse link
G Rgs14 regulator of G protein signaling 14 ISO (MGI:5009199|PMID:10926822) UniProt PMID:10926822 MGI:5009199 NCBI chrNW_004955408:29,602,654...29,616,793
Ensembl chrNW_004955408:29,602,820...29,616,210
JBrowse link
G Rgs2 regulator of G protein signaling 2 ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023, PMID:19127022, PMID:21798518 MGI:3836877, RGD:633858, RGD:7207364 NCBI chrNW_004955406:30,261,757...30,265,389
Ensembl chrNW_004955406:30,261,757...30,266,005
JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO RGD PMID:9918533, PMID:21798518 RGD:7207364, RGD:7207376 NCBI chrNW_004955462:13,340,812...13,347,598
Ensembl chrNW_004955462:13,338,960...13,347,610
JBrowse link
G Rpgrip1l RPGRIP1 like ISO (PMID:19464661) UniProtKB PMID:19464661 NCBI chrNW_004955433:11,321,504...11,423,981
Ensembl chrNW_004955433:11,322,590...11,424,569
JBrowse link
G Rph3al rabphilin 3A like (without C2 domains) ISO (MGI:3044444|PMID:15159548) MGI PMID:15159548 MGI:3044444 NCBI chrNW_004955481:1,903,361...2,054,891
Ensembl chrNW_004955481:1,903,162...2,054,998
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO (PMID:21224381) UniProtKB PMID:21224381 NCBI chrNW_004955445:12,451,644...12,474,251
Ensembl chrNW_004955445:12,448,760...12,474,251
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004955574:140,307...153,684
Ensembl chrNW_004955574:140,307...156,899
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO PMID:18223549
(MGI:84440|PMID:7761854)
(MGI:1337704|PMID:10338466)
BHF-UCL
MGI
RGD
PMID:7761854, PMID:10338466, PMID:17908240, PMID:18223549, PMID:30075183 MGI:1337704, MGI:84440, RGD:13792694, RGD:7242040, RGD:8553863 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966, PMID:20837135 RGD:5685022, RGD:5685621 NCBI chrNW_004955442:19,640,145...19,785,803
Ensembl chrNW_004955442:19,640,145...19,785,803
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574, PMID:30075183 RGD:13792694, RGD:61618 NCBI chrNW_004955551:43,918...255,118
Ensembl chrNW_004955551:44,156...254,534
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chrNW_004955408:29,665,534...29,684,225
Ensembl chrNW_004955408:29,665,260...29,684,207
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004955414:4,424,245...4,919,399 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO (PMID:15123695) HGNC PMID:15123695 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
JBrowse link
G Adrb3 adrenoceptor beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chrNW_004955463:13,663,064...13,665,553 JBrowse link
G Arrb2 arrestin beta 2 ISO (PMID:12582207) RGD
UniProtKB
PMID:12582207, PMID:20705669 RGD:5509896 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gprasp1 G protein-coupled receptor associated sorting protein 1 ISO (PMID:23954414) UniProtKB
MGI
PMID:23954414 NCBI chrNW_004955548:132,373...137,817
Ensembl chrNW_004955548:133,425...137,468
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chrNW_004955414:25,951,473...25,953,593
Ensembl chrNW_004955414:25,951,349...25,953,645
JBrowse link
G Arrb1 arrestin beta 1 ISO (PMID:10521508), (PMID:12582207) UniProtKB PMID:10521508, PMID:12582207 NCBI chrNW_004955414:16,478,843...16,568,050
Ensembl chrNW_004955414:16,478,843...16,562,135
JBrowse link
G Arrb2 arrestin beta 2 ISO (PMID:12582207)
(PMID:10644702)
UniProtKB PMID:10644702, PMID:12582207 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004955570:752,335...781,770
Ensembl chrNW_004955570:752,335...781,770
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818
JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573
JBrowse link
G Drd3 dopamine receptor D3 ISO (PMID:18424554) RGD
BHF-UCL
PMID:14617818, PMID:18424554 RGD:1581465 NCBI chrNW_004955427:14,219,519...14,252,178
Ensembl chrNW_004955427:14,219,594...14,252,178
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004955502:5,640,919...5,646,899
Ensembl chrNW_004955502:5,645,644...5,646,816
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004955453:4,352,278...4,367,807
Ensembl chrNW_004955453:4,351,668...4,367,807
JBrowse link
G Pld2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chrNW_004955467:10,239,177...10,250,516
Ensembl chrNW_004955467:10,239,177...10,250,890
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO (PMID:16670267) UniProtKB PMID:16670267 NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 ISO (MGI:5302794|PMID:21982743) MGI PMID:21982743 MGI:5302794 NCBI chrNW_004955418:20,538,858...20,550,876
Ensembl chrNW_004955418:20,538,983...20,548,862
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) BHF-UCL PMID:17242280 NCBI chrNW_004955406:39,552,034...39,645,694
Ensembl chrNW_004955406:39,552,019...39,645,694
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chrNW_004955532:2,059,038...2,079,120
Ensembl chrNW_004955532:2,059,038...2,079,957
JBrowse link
G Pde4b phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chrNW_004955423:24,464,503...24,906,409
Ensembl chrNW_004955423:24,463,953...24,906,394
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp1 amyloid beta precursor like protein 1 ISO (PMID:16531006) BHF-UCL PMID:16531006 NCBI chrNW_004955468:2,694,286...2,703,658
Ensembl chrNW_004955468:2,694,591...2,703,656
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004955551:43,918...255,118
Ensembl chrNW_004955551:44,156...254,534
JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004955407:31,833,469...31,847,043 JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004955411:11,582,317...11,628,874
Ensembl chrNW_004955411:11,582,234...11,628,892
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004955528:161,673...184,515
Ensembl chrNW_004955528:161,673...167,937
JBrowse link
G Oprm1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817
JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G protein signaling 2 ISO (MGI:5009116|PMID:21291891) BHF-UCL PMID:21291891 MGI:5009116 NCBI chrNW_004955406:30,261,757...30,265,389
Ensembl chrNW_004955406:30,261,757...30,266,005
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) UniProtKB PMID:17689978 NCBI chrNW_004955564:257,781...279,937
Ensembl chrNW_004955564:258,222...277,889
JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18199683) UniProtKB PMID:18199683 NCBI chrNW_004955475:3,260,209...3,263,586
Ensembl chrNW_004955475:3,260,503...3,262,380
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 ISO PMID:20164183
(MGI:4887309|PMID:20164183)
BHF-UCL PMID:20164183 MGI:4887309, RGD:8693367 NCBI chrNW_004955505:3,330,933...3,544,752
Ensembl chrNW_004955505:3,336,803...3,544,752
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647
JBrowse link
G Snca synuclein alpha ISO (PMID:12239163) UniProtKB PMID:12239163 NCBI chrNW_004955405:854,011...962,741
Ensembl chrNW_004955405:853,946...965,403
JBrowse link
G Stmn1 stathmin 1 ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004955452:5,387,696...5,393,337
Ensembl chrNW_004955452:5,388,150...5,391,518
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chrNW_004955403:40,257,467...40,266,275 JBrowse link
G Apln apelin ISO PMID:11359874
(MGI:5902690|PMID:11359874)
(PMID:11359874)
UniProt
UniProtKB
PMID:11359874 MGI:5902690, RGD:12907555 NCBI chrNW_004955473:5,346,822...5,356,359
Ensembl chrNW_004955473:5,346,747...5,356,359
JBrowse link
G App amyloid beta precursor protein ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chrNW_004955511:2,321,445...2,324,417
Ensembl chrNW_004955511:2,322,920...2,324,068
JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chrNW_004955514:2,081,575...2,154,414
Ensembl chrNW_004955514:2,088,354...2,154,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    cellular process 11098
      signal transduction 3677
        G protein-coupled receptor signaling pathway 449
          negative regulation of G protein-coupled receptor signaling pathway 55
            G protein-coupled receptor catabolic process 1
            desensitization of G protein-coupled receptor signaling pathway + 27
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8725
      regulation of biological process 8270
        regulation of cellular process 7845
          regulation of cell communication 2875
            negative regulation of cell communication 1253
              negative regulation of signal transduction 1125
                negative regulation of G protein-coupled receptor signaling pathway 55
                  G protein-coupled receptor catabolic process 1
                  desensitization of G protein-coupled receptor signaling pathway + 27
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.