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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 IEA Ensembl GO_REF:0000107 NCBI chr 9:37,817,409...37,823,852
Ensembl chr 9:37,817,305...37,823,852
JBrowse link
G CRY1 cryptochrome circadian regulator 1 IEA Ensembl GO_REF:0000107 NCBI chr10:31,681,098...31,792,995
Ensembl chr10:31,681,288...31,780,306
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 IEA Ensembl GO_REF:0000107 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G KLK14 kallikrein related peptidase 14 IEA Ensembl GO_REF:0000107 NCBI chr 1:105,811,435...105,816,625
Ensembl chr 1:105,812,224...105,816,625
JBrowse link
G MGRN1 mahogunin ring finger 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 6:36,716,071...36,775,893
Ensembl chr 6:36,716,343...36,769,417
JBrowse link
G PLEK pleckstrin IEA Ensembl GO_REF:0000107 NCBI chr10:67,395,972...67,421,247
Ensembl chr10:67,395,972...67,421,247
JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 3:60,917,033...61,011,812
Ensembl chr 3:60,917,072...61,009,131
JBrowse link
G RGS13 regulator of G protein signaling 13 IEA Ensembl GO_REF:0000107 NCBI chr38:6,291,146...6,316,662
Ensembl chr38:6,291,182...6,315,198
JBrowse link
G RGS14 regulator of G protein signaling 14 IEA Ensembl GO_REF:0000107 NCBI chr 4:35,984,970...35,999,386
Ensembl chr 4:35,985,132...35,999,294
JBrowse link
G RGS2 regulator of G protein signaling 2 ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023, PMID:19127022, PMID:21798518 MGI:3836877, RGD:633858, RGD:7207364 NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494
JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:9918533, PMID:21798518 RGD:7207364, RGD:7207376 NCBI chr38:19,771,454...19,778,917
Ensembl chr38:19,771,441...19,779,190
JBrowse link
G RNF157 ring finger protein 157 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:4,416,423...4,511,793
Ensembl chr 9:4,432,498...4,511,794
JBrowse link
G RPGRIP1L RPGRIP1 like IEA Ensembl GO_REF:0000107 NCBI chr 2:62,080,159...62,179,694
Ensembl chr 2:62,080,080...62,178,284
JBrowse link
G RPH3AL rabphilin 3A like (without C2 domains) IEA Ensembl GO_REF:0000107 NCBI chr 9:45,315,713...45,421,937
Ensembl chr 9:45,320,027...45,420,981
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta IEA Ensembl GO_REF:0000107 NCBI chr24:32,304,808...32,325,789
Ensembl chr24:32,304,812...32,323,938
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 1:109,898,617...109,909,331
Ensembl chr 1:109,899,874...109,909,410
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966, PMID:20837135 RGD:5685022, RGD:5685621 NCBI chr26:19,385,059...19,512,528
Ensembl chr26:19,385,058...19,516,077
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 3:61,233,066...61,331,094
Ensembl chr 3:61,079,904...61,330,290
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574, PMID:30075183 RGD:13792694, RGD:61618 NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr 4:35,927,470...35,943,218
Ensembl chr 4:35,913,472...35,943,221
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr21:10,980,186...11,496,539
Ensembl chr21:10,996,075...11,493,290
JBrowse link
G LOC102154767 lymphocyte antigen 6G6e-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:1,189,910...1,196,762 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 6:74,932,789...74,986,573 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 ISS
IEA
HGNC
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chr16:27,445,601...27,446,796
Ensembl chr16:27,445,601...27,447,521
JBrowse link
G ARRB2 arrestin beta 2 ISO (PMID:12582207) RGD
UniProtKB
PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 IEA InterPro GO_REF:0000002 NCBI chr 7:33,318,124...33,356,388
Ensembl chr 7:33,317,730...33,350,325
JBrowse link
G GPRASP1 G protein-coupled receptor associated sorting protein 1 ISO (PMID:23954414) UniProtKB
MGI
PMID:23954414 NCBI chr  X:76,274,196...76,318,204
Ensembl chr  X:76,313,740...76,318,607
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin IEA Ensembl GO_REF:0000107 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495
JBrowse link
G ARR3 arrestin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:54,725,034...54,730,920
Ensembl chr  X:54,718,323...54,730,852
JBrowse link
G ARRB1 arrestin beta 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786
JBrowse link
G ARRB2 arrestin beta 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454
JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645
JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr20:50,398,866...50,487,303
Ensembl chr20:50,398,864...50,487,241
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
G DRD3 dopamine receptor D3 IEA Ensembl GO_REF:0000107 NCBI chr33:18,369,362...18,414,465
Ensembl chr33:18,372,865...18,412,277
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 3:61,233,066...61,331,094
Ensembl chr 3:61,079,904...61,330,290
JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 ISO (PMID:15775968) UniProtKB PMID:15775968 NCBI chr 2:54,553,871...54,579,695
Ensembl chr 2:54,554,578...54,628,670
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B IEA Ensembl GO_REF:0000107 NCBI chr12:38,659,088...38,659,546 JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IEA Ensembl GO_REF:0000107 NCBI chr25:43,042,306...43,056,361
Ensembl chr25:43,042,173...43,056,612
JBrowse link
G PLD2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr 5:31,755,881...31,767,131
Ensembl chr 5:31,756,433...31,767,066
JBrowse link
G SAG S-antigen visual arrestin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:44,800,141...44,843,580
Ensembl chr25:44,812,362...44,843,579
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRDC3 arrestin domain containing 3 IEA Ensembl GO_REF:0000107 NCBI chr 3:17,691,631...17,705,507
Ensembl chr 3:17,691,961...17,703,308
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 IEA Ensembl GO_REF:0000107 NCBI chr38:321,246...420,262
Ensembl chr38:366,656...416,952
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697
JBrowse link
G PDE4B phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chr 5:44,063,145...44,606,070
Ensembl chr 5:44,065,106...44,500,999
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLP1 amyloid beta precursor like protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 1:116,774,392...116,783,101
Ensembl chr 1:116,728,529...116,783,046
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741
JBrowse link
G MRAP melanocortin 2 receptor accessory protein ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr31:27,058,469...27,085,704
Ensembl chr31:27,058,366...27,087,573
JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 IEA Ensembl GO_REF:0000107 NCBI chr12:44,323,932...44,373,170
Ensembl chr12:44,324,197...44,373,138
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr24:47,530,039...47,537,477
Ensembl chr24:47,508,136...47,537,250
JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr 1:43,972,915...44,037,477
Ensembl chr 1:43,972,219...44,141,238
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chr 6:74,932,789...74,986,573 JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 IEA Ensembl GO_REF:0000107 NCBI chr38:6,200,237...6,203,491
Ensembl chr38:6,200,657...6,203,494
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) UniProtKB PMID:17689978 NCBI chr 5:68,313,699...68,342,253
Ensembl chr 5:68,314,000...68,378,311
JBrowse link
G UBQLN2 ubiquilin 2 ISO (PMID:18199683) UniProtKB PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BICD1 BICD cargo adaptor 1 IEA Ensembl GO_REF:0000107 NCBI chr27:16,478,323...16,618,429
Ensembl chr27:16,484,121...16,612,044
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027
JBrowse link
G SNCA synuclein alpha IEA Ensembl GO_REF:0000107 NCBI chr32:12,915,871...13,079,338
Ensembl chr32:12,916,215...13,060,383
JBrowse link
G STMN1 stathmin 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:74,035,462...74,043,352
Ensembl chr 2:74,035,457...74,043,349
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chr15:60,967,944...60,990,955 JBrowse link
G APLN apelin ISO (PMID:11359874)
(MGI:5902690|PMID:11359874)
UniProtKB
UniProt
PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:100,863,360...100,873,105 JBrowse link
G APP amyloid beta precursor protein ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor IEA Ensembl GO_REF:0000107 NCBI chr18:38,878,621...38,882,280
Ensembl chr18:38,878,947...38,886,206
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:74,932,789...74,986,573 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:74,932,789...74,986,573 JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chr 3:60,917,033...61,011,812
Ensembl chr 3:60,917,072...61,009,131
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    cellular process 15467
      signal transduction 5457
        G protein-coupled receptor signaling pathway 1370
          negative regulation of G protein-coupled receptor signaling pathway 62
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 31
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 16190
    biological regulation 11558
      regulation of biological process 10960
        regulation of cellular process 10500
          regulation of cell communication 3300
            negative regulation of cell communication 1344
              negative regulation of signal transduction 1215
                negative regulation of G protein-coupled receptor signaling pathway 62
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 31
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.