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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 IDA (PMID:10734056) UniProtKB PMID:10734056 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CRY1 cryptochrome circadian regulator 1 ISS UniProtKB GO_REF:0000024 NCBI chr12:106,991,364...107,093,872
Ensembl chr12:106,991,364...107,093,549
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 IDA (PMID:10734056) UniProtKB PMID:10734056 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G KLK14 kallikrein related peptidase 14 IDA (PMID:16885167) UniProtKB PMID:16885167 NCBI chr19:51,077,494...51,084,210
Ensembl chr19:51,077,495...51,084,245
JBrowse link
G MGRN1 mahogunin ring finger 1 IDA
IBA
(PMID:19737927)
(PMID:21873635)
UniProtKB
GO_Central
PMID:19737927, PMID:21873635 NCBI chr16:4,624,826...4,690,972
Ensembl chr16:4,616,493...4,690,974
JBrowse link
G PLEK pleckstrin IDA (PMID:7782310) BHF-UCL PMID:7782310 NCBI chr 2:68,365,282...68,397,453
Ensembl chr 2:68,365,282...68,397,453
JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 4:3,292,978...3,439,913
Ensembl chr 4:3,293,028...3,439,913
JBrowse link
G RGS13 regulator of G protein signaling 13 IEA Ensembl GO_REF:0000107 NCBI chr 1:192,636,147...192,660,311
Ensembl chr 1:192,636,138...192,660,306
JBrowse link
G RGS14 regulator of G protein signaling 14 ISS UniProtKB GO_REF:0000024 NCBI chr 5:177,357,672...177,372,601
Ensembl chr 5:177,357,924...177,372,596
JBrowse link
G RGS2 regulator of G protein signaling 2 ISS BHF-UCL GO_REF:0000024 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
G RGS4 regulator of G protein signaling 4 IEA Ensembl GO_REF:0000107 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802
JBrowse link
G RNF157 ring finger protein 157 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:76,142,456...76,240,493
Ensembl chr17:76,142,465...76,240,493
JBrowse link
G RPGRIP1L RPGRIP1 like IDA (PMID:19464661) UniProtKB PMID:19464661 NCBI chr16:53,598,153...53,703,859
Ensembl chr16:53,598,153...53,703,938
JBrowse link
G RPH3AL rabphilin 3A like (without C2 domains) IEA Ensembl GO_REF:0000107 NCBI chr17:212,389...352,807
Ensembl chr17:212,389...386,254
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta IMP (PMID:21224381) UniProtKB PMID:21224381 NCBI chr20:44,885,705...44,908,532
Ensembl chr20:44,885,702...44,908,532
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor IEA Ensembl GO_REF:0000107 NCBI chr19:45,668,187...45,683,722
Ensembl chr19:45,668,221...45,683,722
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISS BHF-UCL GO_REF:0000024 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966, PMID:20837135 RGD:5685022, RGD:5685621 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574, PMID:30075183 RGD:13792694, RGD:61618 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr 5:177,426,496...177,442,891
Ensembl chr 5:177,403,204...177,442,901
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:88,504,576...89,065,982
Ensembl chr11:88,504,576...89,065,945
JBrowse link
G LY6G6E lymphocyte antigen 6 family member G6E IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:31,711,976...31,714,065
Ensembl chr 6:31,711,771...31,714,065
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 IDA (PMID:15123695) HGNC PMID:15123695 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,825,245...148,828,687
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT IDA (PMID:15123695) HGNC PMID:15123695 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G ARRB2 arrestin beta 2 IMP (PMID:12582207) UniProtKB PMID:12582207 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 IPI
IMP
(PMID:23954414) MGI
UniProtKB
PMID:23954414 NCBI chr 1:241,957,767...241,959,062
Ensembl chr 1:241,957,767...241,959,062
JBrowse link
G GPRASP1 G protein-coupled receptor associated sorting protein 1 IPI
IMP
(PMID:23954414) MGI
UniProtKB
PMID:23954414 NCBI chr  X:102,651,483...102,659,083
Ensembl chr  X:102,651,092...102,659,083
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin IDA (PMID:10882736) UniProtKB PMID:10882736 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G ARR3 arrestin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:70,268,334...70,281,840
Ensembl chr  X:70,268,305...70,281,840
JBrowse link
G ARRB1 arrestin beta 1 IMP
IBA
(PMID:10521508), (PMID:12582207)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10521508, PMID:12582207, PMID:21873635 NCBI chr11:75,260,122...75,351,662
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ARRB2 arrestin beta 2 TAS
IBA
IDA
IMP
(PMID:24157794)
(PMID:21873635)
(PMID:10644702)
(PMID:12582207)
ParkinsonsUK-UCL
GO_Central
UniProtKB
PMID:10644702, PMID:12582207, PMID:21873635, PMID:24157794 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G CALCA calcitonin related polypeptide alpha IDA (PMID:10882736) UniProtKB PMID:10882736 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G DNM1 dynamin 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248
JBrowse link
G DNM2 dynamin 2 IEA Ensembl GO_REF:0000107 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,079...10,833,488
JBrowse link
G DRD2 dopamine receptor D2 IEA Ensembl GO_REF:0000107 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD3 dopamine receptor D3 IDA (PMID:18424554) BHF-UCL PMID:18424554 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 IEA Ensembl GO_REF:0000107 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 IMP (PMID:15775968) UniProtKB PMID:15775968 NCBI chr 5:71,035,124...71,109,113
Ensembl chr 5:71,032,670...71,067,689
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B IEA Ensembl GO_REF:0000107 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,461,753...77,463,773
Ensembl chr 6:77,461,753...77,463,773
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IEA Ensembl GO_REF:0000107 NCBI chr 2:231,108,230...231,126,172
Ensembl chr 2:231,108,230...231,125,042
JBrowse link
G PLD2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G SAG S-antigen visual arrestin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:233,307,816...233,347,066
Ensembl chr 2:233,307,816...233,347,055
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,217,154...44,326,167
Ensembl chr 7:44,217,150...44,334,577
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IDA
IBA
(PMID:16670267)
(PMID:21873635)
UniProtKB
GO_Central
PMID:16670267, PMID:21873635 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRDC3 arrestin domain containing 3 IEA Ensembl GO_REF:0000107 NCBI chr 5:91,368,631...91,383,332
Ensembl chr 5:91,368,631...91,383,317
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 IDA (PMID:17242280) BHF-UCL PMID:17242280 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,787...203,744,081
Ensembl chr 1:203,626,787...203,744,081
JBrowse link
G GNAI2 G protein subunit alpha i2 IEA Ensembl GO_REF:0000107 NCBI chr 3:50,227,068...50,259,362
Ensembl chr 3:50,226,292...50,259,362
JBrowse link
G PDE4B phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLP1 amyloid beta precursor like protein 1 IDA (PMID:16531006) BHF-UCL PMID:16531006 NCBI chr19:35,868,570...35,879,795
Ensembl chr19:35,867,899...35,879,791
Ensembl chr19:35,867,899...35,879,791
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G MRAP melanocortin 2 receptor accessory protein IDA (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr21:32,291,813...32,314,784
Ensembl chr21:32,291,813...32,314,784
JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 IDA (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr 6:84,032,621...84,146,278
Ensembl chr 6:84,033,772...84,090,881
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 IEA Ensembl GO_REF:0000107 NCBI chr20:64,080,082...64,100,643
Ensembl chr20:64,080,082...64,100,643
JBrowse link
G OPRM1 opioid receptor mu 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
G SSTR4 somatostatin receptor 4 IEA Ensembl GO_REF:0000107 NCBI chr20:23,035,312...23,039,237
Ensembl chr20:23,035,312...23,039,237
Ensembl chr20:23,035,312...23,039,237
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 ISS BHF-UCL GO_REF:0000024 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 IDA (PMID:17689978) UniProtKB PMID:17689978 NCBI chr16:83,968,244...84,002,776
Ensembl chr16:83,968,632...84,002,776
JBrowse link
G UBQLN2 ubiquilin 2 IMP (PMID:18199683) UniProtKB PMID:18199683 NCBI chr  X:56,563,627...56,567,868
Ensembl chr  X:56,563,627...56,567,868
Ensembl chr  X:56,563,627...56,567,868
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BICD1 BICD cargo adaptor 1 ISS BHF-UCL GO_REF:0000024 NCBI chr12:32,106,773...32,383,637
Ensembl chr12:32,106,835...32,383,633
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase IDA (PMID:25198505) CAFA PMID:25198505 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
G SNCA synuclein alpha IDA (PMID:12239163) UniProtKB PMID:12239163 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G STMN1 stathmin 1 IMP (PMID:25198505) CAFA PMID:25198505 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand IMP (PMID:25639753) UniProtKB PMID:25639753 NCBI chr 4:164,877,023...164,899,063
Ensembl chr 4:164,877,178...164,898,965
JBrowse link
G APLN apelin IDA (PMID:11359874) UniProtKB PMID:11359874 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G APP amyloid beta precursor protein IDA (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor IMP (PMID:25639753) UniProtKB PMID:25639753 NCBI chr11:57,233,591...57,237,430
Ensembl chr11:57,233,577...57,237,235
Ensembl chr11:57,233,577...57,237,235
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chr 4:3,292,978...3,439,913
Ensembl chr 4:3,293,028...3,439,913
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18673
    cellular process 17693
      signal transduction 6574
        G protein-coupled receptor signaling pathway 1433
          negative regulation of G protein-coupled receptor signaling pathway 64
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 32
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 18673
    biological regulation 13311
      regulation of biological process 12643
        regulation of cellular process 12041
          regulation of cell communication 3868
            negative regulation of cell communication 1542
              negative regulation of signal transduction 1406
                negative regulation of G protein-coupled receptor signaling pathway 64
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 32
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.