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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 chemokine (C-C motif) ligand 5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Cry1 cryptochrome 1 (photolyase-like) IMP (MGI:5567906|PMID:20852621) UniProt PMID:20852621 MGI:5567906 NCBI chr10:85,131,700...85,185,054
Ensembl chr10:85,131,700...85,185,064
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Klk14 kallikrein related-peptidase 14 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:43,680,880...43,695,536
Ensembl chr 7:43,690,418...43,695,536
JBrowse link
G Mgrn1 mahogunin, ring finger 1 IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr16:4,886,100...4,938,296
Ensembl chr16:4,886,249...4,938,296
JBrowse link
G Plek pleckstrin ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:16,971,206...17,008,718
Ensembl chr11:16,971,206...17,052,381
JBrowse link
G Rgs12 regulator of G-protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 5:34,948,929...35,039,642
Ensembl chr 5:34,949,445...35,039,644
JBrowse link
G Rgs13 regulator of G-protein signaling 13 IDA (MGI:2385407|PMID:12193720) MGI PMID:12193720 MGI:2385407 NCBI chr 1:144,137,386...144,177,372
Ensembl chr 1:144,138,654...144,177,372
JBrowse link
G Rgs14 regulator of G-protein signaling 14 IDA (MGI:5009199|PMID:10926822) UniProt PMID:10926822 MGI:5009199 NCBI chr13:55,369,732...55,384,687
Ensembl chr13:55,369,732...55,384,687
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO
IMP
(MGI:3836877|PMID:19127022) MGI
BHF-UCL
PMID:19127022 GO_REF:0000096, MGI:3836877, MGI:4417868 NCBI chr 1:143,999,338...144,004,149
Ensembl chr 1:143,999,338...144,004,161
JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 1:169,741,477...169,747,642
Ensembl chr 1:169,741,477...169,747,642
JBrowse link
G Rnf157 ring finger protein 157 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:116,336,345...116,413,391
Ensembl chr11:116,336,353...116,413,032
JBrowse link
G Rpgrip1l Rpgrip1-like ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:91,217,030...91,313,291
Ensembl chr 8:91,217,030...91,313,262
JBrowse link
G Rph3al rabphilin 3A-like (without C2 domains) IMP (MGI:3044444|PMID:15159548) MGI PMID:15159548 MGI:3044444 NCBI chr11:75,830,992...75,967,614
Ensembl chr11:75,830,999...75,938,429
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:163,995,197...164,018,588
Ensembl chr 2:163,994,960...164,018,588
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 7:19,156,063...19,170,248
Ensembl chr 7:19,156,061...19,166,127
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP
ISO
IGI
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
MGI PMID:7761854, PMID:10338466 GO_REF:0000096, MGI:1337704, MGI:4417868, MGI:84440 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 5:112,910,478...113,015,660
Ensembl chr 5:112,910,482...113,015,791
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 5:34,660,250...34,755,305
Ensembl chr 5:34,660,379...34,755,305
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr13:55,445,072...55,460,927
Ensembl chr13:55,445,072...55,460,927
JBrowse link
G Grm5 glutamate receptor, metabotropic 5 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 7:87,583,981...88,135,063
Ensembl chr 7:87,584,168...88,134,907
JBrowse link
G Ly6g6e lymphocyte antigen 6 complex, locus G6E IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:5694852|PMID:26276394)
GO_Central
MGI
PMID:21873635, PMID:26276394 MGI:5694852, MGI:6201960 NCBI chr17:35,076,868...35,078,804
Ensembl chr17:35,076,902...35,078,804
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenergic receptor, beta 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Adrb3 adrenergic receptor, beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Arrb2 arrestin, beta 2 ISO MGI GO_REF:0000096, MGI:4417868, MGI:4834177 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn2 beclin 2 IMP
ISO
(MGI:5528919|PMID:23954414) MGI PMID:23954414 MGI:5528919 NCBI chr 1:175,920,329...175,922,225
Ensembl chr 1:175,920,329...175,922,225
JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 ISO (MGI:5528919|PMID:23954414) MGI PMID:23954414 GO_REF:0000096, MGI:4834177, MGI:5528919 NCBI chr  X:135,742,692...135,803,468
Ensembl chr  X:135,742,733...135,803,474
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:110,627,657...110,629,820
Ensembl chr 7:110,627,661...110,629,820
JBrowse link
G Arr3 arrestin 3, retinal IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:100,605,480...100,618,493
Ensembl chr  X:100,605,497...100,618,493
JBrowse link
G Arrb1 arrestin, beta 1 IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 7:99,535,147...99,606,772
Ensembl chr 7:99,535,466...99,606,771
JBrowse link
G Arrb2 arrestin, beta 2 ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Dnm1 dynamin 1 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 2:32,308,471...32,353,349
Ensembl chr 2:32,308,471...32,353,338
JBrowse link
G Dnm2 dynamin 2 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 9:21,424,908...21,507,759
Ensembl chr 9:21,424,908...21,507,759
JBrowse link
G Drd2 dopamine receptor D2 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Drd3 dopamine receptor D3 ISO MGI GO_REF:0000096, MGI:4417868, MGI:4834177 NCBI chr16:43,754,015...43,825,982
Ensembl chr16:43,754,026...43,822,932
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 5:34,660,250...34,755,305
Ensembl chr 5:34,660,379...34,755,305
JBrowse link
G Gtf2h2 general transcription factor II H, polypeptide 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:100,460,218...100,492,609
Ensembl chr13:100,460,218...100,492,579
JBrowse link
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B IDA (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 9:81,628,291...81,633,832
Ensembl chr 9:81,628,291...81,633,828
JBrowse link
G Htr2b 5-hydroxytryptamine (serotonin) receptor 2B IDA (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chr 1:86,097,546...86,116,231
Ensembl chr 1:86,099,026...86,111,970
JBrowse link
G Pld2 phospholipase D2 IDA (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr11:70,539,492...70,558,110
Ensembl chr11:70,540,064...70,558,110
JBrowse link
G Sag S-antigen, retina and pineal gland (arrestin) IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:87,798,143...87,845,158
Ensembl chr 1:87,803,680...87,845,158
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II, beta IDA (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr11:5,969,629...6,066,357
Ensembl chr11:5,969,644...6,066,362
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 IMP (MGI:5302794|PMID:21982743) MGI PMID:21982743 MGI:5302794 NCBI chr13:80,883,384...80,896,042
Ensembl chr13:80,883,384...80,896,042
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:133,702,674...133,801,059
Ensembl chr 1:133,699,457...133,801,041
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 9:107,614,125...107,635,391
Ensembl chr 9:107,614,125...107,635,367
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific IMP (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp1 amyloid beta (A4) precursor-like protein 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:30,434,980...30,445,582
Ensembl chr 7:30,434,982...30,445,535
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr19:4,285,999...4,306,222
Ensembl chr19:4,286,001...4,306,222
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr19:60,889,560...61,095,968
Ensembl chr19:60,889,749...61,095,968
JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr16:90,738,207...90,749,785
Ensembl chr16:90,738,207...90,749,785
JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:87,144,236...87,184,051
Ensembl chr 9:87,144,306...87,184,045
JBrowse link
G Oprl1 opioid receptor-like 1 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 2:181,715,000...181,720,985
Ensembl chr 2:181,715,016...181,720,985
JBrowse link
G Oprm1 opioid receptor, mu 1 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
G Sstr4 somatostatin receptor 4 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 2:148,395,377...148,396,764
Ensembl chr 2:148,395,344...148,396,767
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G-protein signaling 2 IMP (MGI:5009116|PMID:21291891) BHF-UCL PMID:21291891 MGI:5009116 NCBI chr 1:143,999,338...144,004,149
Ensembl chr 1:143,999,338...144,004,161
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:119,446,719...119,472,640
Ensembl chr 8:119,446,719...119,472,640
JBrowse link
G Ubqln2 ubiquilin 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr  X:153,498,232...153,501,562
Ensembl chr  X:153,498,227...153,501,570
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 ISO
IDA
(MGI:4887309|PMID:20164183) MGI
BHF-UCL
PMID:20164183 GO_REF:0000096, MGI:4417868, MGI:4887309 NCBI chr 6:149,408,824...149,563,329
Ensembl chr 6:149,408,886...149,563,329
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met met proto-oncogene ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 6:17,463,349...17,573,980
Ensembl chr 6:17,463,800...17,573,980
JBrowse link
G Snca synuclein, alpha ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Stmn1 stathmin 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:134,468,320...134,473,843
Ensembl chr 4:134,468,320...134,473,843
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chr 8:65,028,417...65,037,336
Ensembl chr 8:65,028,417...65,037,336
JBrowse link
G Apln apelin IDA
ISO
(MGI:5902690|PMID:11359874) UniProt
MGI
PMID:11359874 GO_REF:0000096, MGI:4417868, MGI:4834177, MGI:5902690 NCBI chr  X:48,025,146...48,034,853
Ensembl chr  X:48,025,146...48,034,853
JBrowse link
G App amyloid beta (A4) precursor protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:85,136,360...85,139,923
Ensembl chr 2:85,136,225...85,139,923
JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 3:157,566,821...157,644,758
Ensembl chr 3:157,566,892...157,645,888
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs12 regulator of G-protein signaling 12 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 5:34,948,929...35,039,642
Ensembl chr 5:34,949,445...35,039,644
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    cellular process 17420
      signal transduction 6326
        G protein-coupled receptor signaling pathway 1996
          negative regulation of G protein-coupled receptor signaling pathway 64
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 32
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 23386
    biological regulation 13124
      regulation of biological process 12484
        regulation of cellular process 11925
          regulation of cell communication 3511
            negative regulation of cell communication 1371
              negative regulation of signal transduction 1237
                negative regulation of G protein-coupled receptor signaling pathway 64
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 32
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.