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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 IEA Ensembl GO_REF:0000107 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CRY1 cryptochrome circadian regulator 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:13,275,265...13,429,566
Ensembl chr 5:13,275,544...13,364,594
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 IEA Ensembl GO_REF:0000107 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G KLK14 kallikrein related peptidase 14 IEA Ensembl GO_REF:0000107 NCBI chr 6:55,719,698...55,726,099
Ensembl chr 6:55,719,728...55,725,473
JBrowse link
G MGRN1 mahogunin ring finger 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:37,694,798...37,748,106
Ensembl chr 3:37,689,708...37,748,068
JBrowse link
G PLEK pleckstrin IEA Ensembl GO_REF:0000107 NCBI chr 3:73,877,741...73,910,163
Ensembl chr 3:73,877,743...74,005,519
JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 8:1,971,390...2,074,970
Ensembl chr 8:1,963,313...2,076,963
JBrowse link
G RGS13 regulator of G protein signaling 13 IEA Ensembl GO_REF:0000107 NCBI chr10:1,056,920...1,082,394
Ensembl chr10:1,057,622...1,082,222
JBrowse link
G RGS14 regulator of G protein signaling 14 IEA Ensembl GO_REF:0000107 NCBI chr 2:80,574,411...80,589,998
Ensembl chr 2:80,574,411...80,590,003
JBrowse link
G RGS2 regulator of G protein signaling 2 ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023 PMID:19127022 PMID:21798518 MGI:3836877 RGD:633858 RGD:7207364 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:9918533 PMID:21798518 RGD:7207364 RGD:7207376 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,381,386...87,390,467
JBrowse link
G RNF157 ring finger protein 157 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:5,225,978...5,306,197
Ensembl chr12:5,226,135...5,307,061
JBrowse link
G RPGRIP1L RPGRIP1 like IEA Ensembl GO_REF:0000107 NCBI chr 6:31,564,937...31,660,540
Ensembl chr 6:31,564,986...31,661,194
JBrowse link
G RPH3AL rabphilin 3A like (without C2 domains) IEA Ensembl GO_REF:0000107 NCBI chr12:47,322,505...47,497,904
Ensembl chr12:47,346,977...47,500,525
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta IEA Ensembl GO_REF:0000107 NCBI chr17:47,298,020...47,317,826
Ensembl chr17:47,298,015...47,319,275
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 6:52,022,667...52,033,959
Ensembl chr 6:52,022,681...52,033,954
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966 PMID:20837135 RGD:5685022 RGD:5685621 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,985
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,135...1,792,861
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,507,009...80,527,210
JBrowse link
G GRM5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,916,815...22,436,063
JBrowse link
G LOC110261493 sperm acrosome membrane-associated protein 4-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:23,823,392...23,825,431 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 ISS
IEA
HGNC
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chr15:48,468,803...48,478,370 JBrowse link
G ARRB2 arrestin beta 2 IEA Ensembl GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,776...52,170,344
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 IEA Ensembl GO_REF:0000107 NCBI chr10:15,388,712...15,390,250
Ensembl chr10:15,388,605...15,390,226
JBrowse link
G GPRASP1 G protein-coupled receptor associated sorting protein 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:83,765,210...83,810,090
Ensembl chr  X:83,765,255...83,811,026
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin IEA Ensembl GO_REF:0000107 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G ARR3 arrestin 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:56,295,107...56,310,507
Ensembl chr  X:56,296,596...56,310,504
JBrowse link
G ARRB1 arrestin beta 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,513,856...9,597,959
JBrowse link
G ARRB2 arrestin beta 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,776...52,170,344
JBrowse link
G CALCB calcitonin-related polypeptide beta ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 1:268,653,045...268,702,233
Ensembl chr 1:268,653,039...268,702,223
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 2:69,474,011...69,574,427
Ensembl chr 2:69,474,031...69,574,424
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 IEA Ensembl GO_REF:0000107 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,510...145,819,173
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,135...1,792,861
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B IEA Ensembl GO_REF:0000107 NCBI chr 1:88,597,510...88,598,682
Ensembl chr 1:88,596,215...88,601,047
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B IEA Ensembl GO_REF:0000107 NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,928...131,860,392
JBrowse link
G PLD2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G SAG S-antigen visual arrestin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:133,704,975...133,741,844
Ensembl chr15:133,691,886...133,741,798
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,957,945
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRDC3 arrestin domain containing 3 IEA Ensembl GO_REF:0000107 NCBI chr 2:98,430,451...98,444,835
Ensembl chr 2:98,430,465...98,444,647
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 IEA Ensembl GO_REF:0000107 NCBI chr 9:64,336,354...64,445,669
Ensembl chr 9:64,336,499...64,445,663
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,363
JBrowse link
G PDE4B phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chr 6:146,167,262...146,720,105
Ensembl chr 6:146,166,681...146,720,127
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLP1 amyloid beta precursor like protein 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:45,285,698...45,295,355
Ensembl chr 6:45,285,698...45,295,352
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G MRAP melanocortin 2 receptor accessory protein ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr13:195,950,949...195,973,501 JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 IEA Ensembl GO_REF:0000107 NCBI chr 1:53,248,311...53,318,111
Ensembl chr 1:53,256,006...53,318,107
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr17:62,905,700...62,913,018
Ensembl chr17:62,897,727...62,913,754
JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 IEA Ensembl GO_REF:0000107 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) UniProtKB PMID:17689978 NCBI chr 6:4,598,752...4,641,450 JBrowse link
G UBQLN2 ubiquilin 2 IEA Ensembl GO_REF:0000107 NCBI chr  X:48,948,062...48,951,392
Ensembl chr  X:48,948,389...48,950,263
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BICD1 BICD cargo adaptor 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:41,897,611...42,143,668
Ensembl chr 5:41,897,376...42,143,641
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase IEA Ensembl GO_REF:0000107 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,044...29,541,512
JBrowse link
G SNCA synuclein alpha IEA Ensembl GO_REF:0000107 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,388,307
JBrowse link
G STMN1 stathmin 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:83,356,404...83,362,546
Ensembl chr 6:83,356,411...83,362,500
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chr 8:53,703,735...53,736,989 JBrowse link
G APLN apelin IEA Ensembl GO_REF:0000107 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor IEA Ensembl GO_REF:0000107
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chr 8:1,971,390...2,074,970
Ensembl chr 8:1,963,313...2,076,963
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16552
    cellular process 15783
      signal transduction 5927
        G protein-coupled receptor signaling pathway 1840
          negative regulation of G protein-coupled receptor signaling pathway 62
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 31
            negative regulation of adenosine receptor signaling pathway 1
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 16552
    biological regulation 12014
      regulation of biological process 11424
        regulation of cellular process 10975
          regulation of cell communication 3302
            negative regulation of cell communication 1343
              negative regulation of signal transduction 1210
                negative regulation of G protein-coupled receptor signaling pathway 62
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 31
                  negative regulation of adenosine receptor signaling pathway 1
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 12
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root