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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0045744 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: down regulation of G-protein coupled receptor protein signaling pathway;   downregulation of G-protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signaling pathway;   negative regulation of G protein coupled receptor protein signalling pathway;   negative regulation of GPCR protein signaling pathway;   negative regulation of GPCR protein signalling pathway
 narrow_synonym: inhibition of G-protein coupled receptor protein signaling pathway


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negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:5567906|PMID:20852621) UniProt PMID:20852621 MGI:5567906 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO (PMID:10734056) UniProtKB PMID:10734056 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Klk14 kallikrein related peptidase 14 ISO (PMID:16885167) UniProtKB PMID:16885167 NCBI chrNW_004936889:714,933...719,305 JBrowse link
G Mgrn1 mahogunin ring finger 1 ISO (PMID:19737927) UniProtKB PMID:19737927 NCBI chrNW_004936530:4,647,550...4,693,143 JBrowse link
G Plek pleckstrin ISO (PMID:7782310) BHF-UCL PMID:7782310 NCBI chrNW_004936491:12,762,421...12,818,249 JBrowse link
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chrNW_004936477:20,300,528...20,388,212 JBrowse link
G Rgs13 regulator of G protein signaling 13 ISO (MGI:2385407|PMID:12193720) MGI PMID:12193720 MGI:2385407 NCBI chrNW_004936638:940,691...963,585 JBrowse link
G Rgs14 regulator of G protein signaling 14 ISO (MGI:5009199|PMID:10926822) UniProt PMID:10926822 MGI:5009199 NCBI chrNW_004936597:1,650,480...1,658,823 JBrowse link
G Rgs2 regulator of G protein signaling 2 ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023, PMID:19127022, PMID:21798518 MGI:3836877, RGD:633858, RGD:7207364 NCBI chrNW_004936638:1,065,866...1,068,649 JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO RGD PMID:9918533, PMID:21798518 RGD:7207364, RGD:7207376 NCBI chrNW_004937238:101,948...109,513 JBrowse link
G Rpgrip1l RPGRIP1 like ISO (PMID:19464661) UniProtKB PMID:19464661 NCBI chrNW_004936475:6,219,187...6,321,612 JBrowse link
G Rph3al rabphilin 3A like (without C2 domains) ISO (MGI:3044444|PMID:15159548) MGI PMID:15159548 MGI:3044444 NCBI chrNW_004936538:7,325,458...7,426,821 JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO (PMID:21224381) UniProtKB PMID:21224381 NCBI chrNW_004936514:7,832,094...7,853,170 JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004936706:2,052,069...2,062,722 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO (MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
PMID:18223549
RGD
MGI
BHF-UCL
PMID:7761854, PMID:10338466, PMID:17908240, PMID:18223549, PMID:30075183 MGI:1337704, MGI:84440, RGD:13792694, RGD:7242040, RGD:8553863 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966, PMID:20837135 RGD:5685022, RGD:5685621 NCBI chrNW_004936657:425,902...522,331 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chrNW_004936477:20,580,794...20,668,259 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574, PMID:30075183 RGD:13792694, RGD:61618 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chrNW_004936597:1,706,671...1,722,370 JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004936736:623,118...1,060,273 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 ISO (PMID:15123695) HGNC PMID:15123695 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Adrb3 adrenoceptor beta 3 NOT ISO (PMID:15123695) HGNC PMID:15123695 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Arrb2 arrestin beta 2 ISO (PMID:12582207) RGD
UniProtKB
PMID:12582207, PMID:20705669 RGD:5509896 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn2 beclin 2 ISO (PMID:23954414)
(MGI:5528919|PMID:23954414)
UniProtKB
MGI
PMID:23954414 MGI:5528919 NCBI chrNW_004936526:8,532,991...8,534,271 JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 ISO (PMID:23954414) UniProtKB
MGI
PMID:23954414 NCBI chrNW_004936813:1,208,018...1,213,224 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO (PMID:10882736) UniProtKB PMID:10882736 NCBI chrNW_004936528:8,005,223...8,007,586 JBrowse link
G Arrb1 arrestin beta 1 ISO (PMID:10521508), (PMID:12582207) UniProtKB PMID:10521508, PMID:12582207 NCBI chrNW_004936498:4,089,621...4,172,749 JBrowse link
G Arrb2 arrestin beta 2 ISO (PMID:12582207)
(PMID:10644702)
UniProtKB PMID:10644702, PMID:12582207 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936659:957,408...1,046,393 JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Drd3 dopamine receptor D3 ISO (PMID:18424554) RGD
BHF-UCL
PMID:14617818, PMID:18424554 RGD:1581465 NCBI chrNW_004936536:1,580,732...1,616,726 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chrNW_004936477:20,580,794...20,668,259 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004936890:154,252...157,044 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004936525:5,711,894...5,729,074 JBrowse link
G Pld2 phospholipase D2 ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chrNW_004936677:2,870,664...2,883,545 JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chrNW_004936478:19,183,493...19,278,457 JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 ISO (MGI:5302794|PMID:21982743) MGI PMID:21982743 MGI:5302794 NCBI chrNW_004936469:9,364,291...9,377,504 JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:17242280) BHF-UCL PMID:17242280 NCBI chrNW_004936567:944,825...1,039,920 JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chrNW_004936529:1,779,582...1,801,251 JBrowse link
G Pde4b phosphodiesterase 4B ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chrNW_004936591:5,152,491...5,666,728 JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp1 amyloid beta precursor like protein 1 ISO (PMID:16531006) BHF-UCL PMID:16531006 NCBI chrNW_004936570:475,446...484,379 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Mrap melanocortin 2 receptor accessory protein ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936500:9,790,435...9,807,101 JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936510:6,905,870...6,945,583 JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004936514:11,264,392...11,273,584 JBrowse link
G Oprm1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004936489:6,506,207...6,567,136 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
G Sstr4 somatostatin receptor 4 ISO RGD PMID:8175684 RGD:2325010 NCBI chrNW_004936620:2,575,880...2,577,761 JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G protein signaling 2 ISO (MGI:5009116|PMID:21291891) BHF-UCL PMID:21291891 MGI:5009116 NCBI chrNW_004936638:1,065,866...1,068,649 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 ISO (PMID:17689978) UniProtKB PMID:17689978 NCBI chrNW_004936641:3,779,024...3,802,883 JBrowse link
G Ubqln2 ubiquilin 2 ISO (PMID:18199683) UniProtKB PMID:18199683 NCBI chrNW_004936819:530,833...534,185 JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 ISO PMID:20164183
(MGI:4887309|PMID:20164183)
BHF-UCL PMID:20164183 MGI:4887309, RGD:8693367 NCBI chrNW_004936607:3,893,350...4,126,813 JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Snca synuclein alpha ISO (PMID:12239163) UniProtKB PMID:12239163 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Stmn1 stathmin 1 ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004936474:10,470,006...10,475,557 JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chrNW_004936555:969,902...978,736 JBrowse link
G Apln apelin ISO PMID:11359874
(MGI:5902690|PMID:11359874)
(PMID:11359874)
UniProt
UniProtKB
PMID:11359874 MGI:5902690, RGD:12907555 NCBI chrNW_004936479:1,889,930...1,899,811 JBrowse link
G App amyloid beta precursor protein ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor ISO (PMID:25639753) UniProtKB PMID:25639753 NCBI chrNW_004936581:5,230,836...5,234,562 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chrNW_004936477:20,300,528...20,388,212 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    cellular process 11179
      signal transduction 3700
        G protein-coupled receptor signaling pathway 449
          negative regulation of G protein-coupled receptor signaling pathway 57
            G protein-coupled receptor catabolic process 2
            desensitization of G protein-coupled receptor signaling pathway + 27
            negative regulation of adenosine receptor signaling pathway 0
            negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
            negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
            negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
            negative regulation of angiotensin-activated signaling pathway 0
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of octopamine or tyramine signaling pathway + 0
            negative regulation of opioid receptor signaling pathway + 0
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            negative regulation of proteinase activated receptor activity 0
            negative regulation of thrombin-activated receptor signaling pathway 3
            suppression by symbiont of host G protein-coupled receptor signal transduction 0
            termination of G protein-coupled receptor signaling pathway 1
Path 2
Term Annotations click to browse term
  biological_process 12002
    biological regulation 8796
      regulation of biological process 8339
        regulation of cellular process 7914
          regulation of cell communication 2884
            negative regulation of cell communication 1256
              negative regulation of signal transduction 1128
                negative regulation of G protein-coupled receptor signaling pathway 57
                  G protein-coupled receptor catabolic process 2
                  desensitization of G protein-coupled receptor signaling pathway + 27
                  negative regulation of adenosine receptor signaling pathway 0
                  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 13
                  negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1
                  negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 0
                  negative regulation of angiotensin-activated signaling pathway 0
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of octopamine or tyramine signaling pathway + 0
                  negative regulation of opioid receptor signaling pathway + 0
                  negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                  negative regulation of proteinase activated receptor activity 0
                  negative regulation of thrombin-activated receptor signaling pathway 3
                  suppression by symbiont of host G protein-coupled receptor signal transduction 0
                  termination of G protein-coupled receptor signaling pathway 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.