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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of Notch signaling pathway
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Accession:GO:0045747 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: positive regulation of N signaling pathway;   positive regulation of N signalling pathway;   positive regulation of Notch signalling pathway;   up regulation of Notch signaling pathway;   upregulation of Notch signaling pathway
 narrow_synonym: activation of Notch signaling pathway;   stimulation of Notch signaling pathway


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positive regulation of Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aak1 AP2 associated kinase 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:21464124)
Ensembl
UniProt
RGD
PMID:21464124, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 4:118,653,851...118,806,796
Ensembl chr 4:118,655,728...118,795,774
JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO MGI:MGI:1857470 (MGI:MGI:3639830|PMID:11073877) RGD PMID:11073877 MGI:MGI:3639830 NCBI chr 7:28,038,662...28,040,504
Ensembl chr 7:28,038,662...28,040,510
JBrowse link
G Bmp2k BMP-2 inducible kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,126,086...14,226,823
Ensembl chr14:14,129,725...14,192,048
JBrowse link
G Ccn3 cellular communication network factor 3 ISS
ISO
GO_REF:0000024
(PMID:12050162), (PMID:20139355)
UniProt
RGD
PMID:12050162, PMID:20139355 GO_REF:0000024 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Cntn6 contactin 6 ISO
IEA
(MGI:MGI:5609887|PMID:25074942)
GO_REF:0000107
RGD
Ensembl
PMID:25074942 GO_REF:0000107, MGI:MGI:5609887 NCBI chr 4:136,512,201...136,904,355
Ensembl chr 4:136,512,201...136,904,355
JBrowse link
G Dll1 delta like canonical Notch ligand 1 IDA
ISO
ISS
IEA
PMID:22658936
(MGI:MGI:3029032|PMID:10958687), (MGI:MGI:3575230|PMID:15574878), (MGI:MGI:3847069|PMID:19144989), (MGI:MGI:3848562|PMID:19389377), (MGI:MGI:5296438|PMID:21915337), (MGI:MGI:5688841|PMID:18676613), (MGI:MGI:5689216|PMID:26114479)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:10958687, PMID:15574878, PMID:18676613, PMID:19144989, PMID:19389377, PMID:21915337, PMID:26114479, PMID:22658936 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3029032, MGI:MGI:3575230, MGI:MGI:3847069, MGI:MGI:3848562, MGI:MGI:5296438, MGI:MGI:5688841, MGI:MGI:5689216, RGD:10402035 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO (MGI:MGI:5689216|PMID:26114479) RGD PMID:26114479 MGI:MGI:5689216 NCBI chr 3:111,135,011...111,146,746
Ensembl chr 3:111,135,021...111,145,986
JBrowse link
G Enho energy homeostasis associated ISO
IBA
(MGI:MGI:5609887|PMID:25074942)
PMID:21873635
RGD PMID:25074942, PMID:21873635 MGI:MGI:5609887, RGD:13792537 NCBI chr 5:58,018,039...58,019,836
Ensembl chr 5:58,018,039...58,019,836
JBrowse link
G Epn2 epsin 2 IEA
ISO
GO_REF:0000107
(PMID:28717225)
Ensembl
RGD
PMID:28717225 GO_REF:0000107 NCBI chr10:47,795,496...47,857,373
Ensembl chr10:47,795,524...47,857,326
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO (MGI:MGI:4950299|PMID:21385765) RGD PMID:21385765 MGI:MGI:4950299 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Fgf10 fibroblast growth factor 10 ISO MGI:MGI:103302 (MGI:MGI:3612905|PMID:16324690) RGD PMID:16324690 MGI:MGI:3612905 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Gsx2 GS homeobox 2 ISO (MGI:MGI:5487482|PMID:23042297) RGD PMID:23042297 MGI:MGI:5487482 NCBI chr14:35,650,985...35,652,709
Ensembl chr14:35,650,985...35,652,709
JBrowse link
G Hes1 hes family bHLH transcription factor 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:3625195|PMID:12208538)
Ensembl
RGD
PMID:12208538 GO_REF:0000107, MGI:MGI:3625195 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hes5 hes family bHLH transcription factor 5 ISO (MGI:MGI:3625195|PMID:12208538) RGD PMID:12208538 MGI:MGI:3625195 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Il6st interleukin 6 signal transducer ISO
IEA
(PMID:25731159)
GO_REF:0000107
(MGI:MGI:5629863|PMID:25731159)
RGD
Ensembl
PMID:25731159 GO_REF:0000107, MGI:MGI:5629863 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO (PMID:20616313) RGD PMID:20616313 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Jag1 jagged canonical Notch ligand 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3029032|PMID:10958687)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10958687 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3029032 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jag2 jagged canonical Notch ligand 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3029032|PMID:10958687)
Ensembl
UniProt
RGD
PMID:10958687 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3029032 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:15302600 RGD:2292509 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO (MGI:MGI:3575230|PMID:15574878) RGD PMID:15574878 MGI:MGI:3575230 NCBI chr12:16,117,767...16,126,211
Ensembl chr12:16,118,634...16,126,953
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO (MGI:MGI:3575230|PMID:15574878) RGD PMID:15574878 MGI:MGI:3575230 NCBI chr 7:119,978,981...119,996,824
Ensembl chr 7:119,978,983...119,996,824
JBrowse link
G Nepro nucleolus and neural progenitor protein ISO
IBA
(MGI:MGI:4411921|PMID:19906856)
PMID:21873635
RGD PMID:19906856, PMID:21873635 MGI:MGI:4411921, RGD:13792537 NCBI chr11:60,919,477...60,931,642
Ensembl chr11:60,919,453...60,931,794
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (MGI:MGI:4946442|PMID:21156799) RGD PMID:21156799 MGI:MGI:4946442 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Notch1 notch receptor 1 ISO (MGI:MGI:5581550|PMID:24667410) RGD PMID:24667410 MGI:MGI:5581550 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Pdcd10 programmed cell death 10 ISO (PMID:23388056) RGD PMID:23388056 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676
JBrowse link
G Poglut1 protein O-glucosyltransferase 1 IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:MGI:5700252|PMID:26496195)
(PMID:27807076)
Ensembl
UniProt
RGD
PMID:26496195, PMID:27807076, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5700252, RGD:13792537 NCBI chr11:64,761,493...64,788,210
Ensembl chr11:64,761,146...64,788,208
JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISO
IEA
(MGI:MGI:3575230|PMID:15574878)
GO_REF:0000107
RGD
Ensembl
PMID:15574878 GO_REF:0000107, MGI:MGI:3575230 NCBI chr10:109,963,726...109,966,821
Ensembl chr10:109,943,817...109,966,826
JBrowse link
G Slc35c2 solute carrier family 35 member C2 ISO (MGI:MGI:4849897|PMID:20837470) RGD PMID:20837470 MGI:MGI:4849897 NCBI chr 3:161,801,194...161,812,318
Ensembl chr 3:161,801,197...161,812,291
JBrowse link
G Sox2 SRY-box transcription factor 2 ISO (MGI:MGI:3640906|PMID:16631155) RGD PMID:16631155 MGI:MGI:3640906 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO
IEA
(PMID:25731159)
GO_REF:0000107
(MGI:MGI:5629863|PMID:25731159)
RGD
Ensembl
PMID:25731159 GO_REF:0000107, MGI:MGI:5629863 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
ISS
(MGI:MGI:5284803|PMID:15156153)
GO_REF:0000024
RGD
UniProt
PMID:15156153 GO_REF:0000024, MGI:MGI:5284803 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
IEA
(PMID:25217442)
GO_REF:0000107
RGD
Ensembl
PMID:25217442 GO_REF:0000107 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tp63 tumor protein p63 ISO MGI:MGI:5140823 (MGI:MGI:5310685|PMID:22274697)
(PMID:11641404)
RGD PMID:11641404, PMID:22274697 MGI:MGI:5310685 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tspan14 tetraspanin 14 ISO (PMID:23091066) RGD PMID:23091066 NCBI chr16:17,538,855...17,595,960
Ensembl chr16:17,538,855...17,595,960
JBrowse link
G Tspan5 tetraspanin 5 ISO (PMID:23091066) RGD PMID:23091066 NCBI chr 2:244,058,186...244,224,059
Ensembl chr 2:244,058,186...244,224,058
JBrowse link
G Wnt1 Wnt family member 1 ISO (PMID:16501043) RGD PMID:16501043 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO
IEA
(PMID:25731159)
GO_REF:0000107
(MGI:MGI:5629863|PMID:25731159)
RGD
Ensembl
PMID:25731159 GO_REF:0000107, MGI:MGI:5629863 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Zmiz1 zinc finger, MIZ-type containing 1 ISO (MGI:MGI:5790022|PMID:26522984) RGD PMID:26522984 MGI:MGI:5790022 NCBI chr16:1,749,191...1,954,633
Ensembl chr16:1,749,191...1,954,614
JBrowse link
positive regulation of Notch signaling pathway involved in heart induction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 ISO (MGI:MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:MGI:5286818 NCBI chr 3:175,701,278...175,709,465
Ensembl chr 3:175,701,280...175,709,465
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Robo1 roundabout guidance receptor 1 ISO (MGI:MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:MGI:5913048 NCBI chr11:9,079,291...10,146,302
Ensembl chr11:9,642,365...10,143,317
JBrowse link
G Robo2 roundabout guidance receptor 2 ISO (MGI:MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:MGI:5913048 NCBI chr11:11,062,866...12,618,793
Ensembl chr11:11,062,790...11,585,765
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      signal transduction 7015
        positive regulation of signal transduction 1682
          positive regulation of Notch signaling pathway 42
            positive regulation of Notch signaling pathway involved in heart induction 4
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            cell surface receptor signaling pathway 2782
              Notch signaling pathway 178
                regulation of Notch signaling pathway 87
                  positive regulation of Notch signaling pathway 42
                    positive regulation of Notch signaling pathway involved in heart induction 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.