ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of action potential
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Accession:GO:0045759 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
Synonyms:exact_synonym: down regulation of action potential;   downregulation of action potential
 narrow_synonym: inhibition of action potential


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negative regulation of action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) JBrowse link 3 89,753,448 89,764,632 RGD:2290270
G Cnr1 cannabinoid receptor 1 (brain) JBrowse link 4 33,923,844 33,948,831 RGD:2290270
G Cnr2 cannabinoid receptor 2 (macrophage) JBrowse link 4 135,895,189 135,920,219 RGD:2290270
G Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 JBrowse link 13 117,602,320 117,981,028 RGD:2290270
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 1 59,639,434 59,670,834 RGD:2290270
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav3 caveolin 3 JBrowse link 6 112,459,505 112,472,872 RGD:2290270
negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 JBrowse link 7 100,176,507 100,184,869 RGD:2290270
negative regulation of neuronal action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpr35 G protein-coupled receptor 35 JBrowse link 1 92,950,860 92,986,391 RGD:2290270
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 JBrowse link 3 107,438,298 107,458,925 RGD:2290270
negative regulation of ventricular cardiac muscle cell action potential term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bin1 bridging integrator 1 JBrowse link 18 32,377,198 32,435,740 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22960
    negative regulation of biological process 5265
      negative regulation of action potential 10
        negative regulation of AV node cell action potential + 0
        negative regulation of atrial cardiac muscle cell action potential + 0
        negative regulation of membrane depolarization during cardiac muscle cell action potential + 1
        negative regulation of membrane repolarization during cardiac muscle cell action potential + 1
        negative regulation of neuronal action potential 2
        negative regulation of ventricular cardiac muscle cell action potential + 2
Path 2
Term Annotations click to browse term
  biological_process 22960
    biological regulation 12083
      regulation of biological quality 4039
        regulation of membrane potential 441
          action potential 132
            regulation of action potential 58
              negative regulation of action potential 10
                negative regulation of AV node cell action potential + 0
                negative regulation of atrial cardiac muscle cell action potential + 0
                negative regulation of membrane depolarization during cardiac muscle cell action potential + 1
                negative regulation of membrane repolarization during cardiac muscle cell action potential + 1
                negative regulation of neuronal action potential 2
                negative regulation of ventricular cardiac muscle cell action potential + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.