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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of blood pressure
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Accession:GO:0045776 term browser browse the term
Definition:Any process in which the force of blood traveling through the circulatory system is decreased.
Synonyms:exact_synonym: down regulation of blood pressure;   downregulation of blood pressure
 narrow_synonym: inhibition of blood pressure


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negative regulation of blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IMP RGD PMID:8336820 RGD:1598530 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO
ISS
(PMID:17327472)
GO_REF:0000024
RGD
UniProt
PMID:17327472 GO_REF:0000024 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adm2 adrenomedullin 2 IMP RGD PMID:14615490 RGD:1304019 NCBI chr 7:130,296,895...130,298,641
Ensembl chr 7:130,296,897...130,298,644
JBrowse link
G Adora1 adenosine A1 receptor IMP RGD PMID:16690710 RGD:5129101 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Apln apelin IDA
IMP
PMID:11359874 RGD
UniProt
PMID:15486224, PMID:11359874, PMID:10617103 RGD:1576349, RGD:12907555, RGD:632247 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:16507603, PMID:15253105 RGD:1625747, RGD:1625759 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 IMP RGD PMID:16507603 RGD:1625747 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Calca calcitonin-related polypeptide alpha IMP
ISO
MGI:2445489|MGI:3527257 (MGI:1352568|PMID:10642343), (MGI:2445452|PMID:11717154), (MGI:3639075|PMID:15583078)
(PMID:10642343)
RGD PMID:10642343, PMID:11717154, PMID:15583078, PMID:11230364 MGI:1352568, MGI:2445452, MGI:3639075, RGD:68890 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19295473 RGD:2314676 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Drd2 dopamine receptor D2 ISO MGI:1857875 (MGI:3608592|PMID:11566895) RGD PMID:11566895 MGI:3608592 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO MGI:1857159 (MGI:3690706|PMID:9691085) RGD PMID:9691085 MGI:3690706 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd5 dopamine receptor D5 IEA
ISO
GO_REF:0000107
MGI:109147|MGI:3528074 (MGI:3526585|PMID:15598876), (MGI:3527993|PMID:12486173)
Ensembl
RGD
PMID:12486173, PMID:15598876 GO_REF:0000107, MGI:3526585, MGI:3527993 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Ffar3 free fatty acid receptor 3 ISS
ISO
GO_REF:0000024
(MGI:5574287|PMID:23401498)
UniProt
RGD
PMID:23401498 GO_REF:0000024, MGI:5574287 NCBI chr 1:89,302,035...89,304,064
Ensembl chr 1:89,302,039...89,303,968
JBrowse link
G Gch1 GTP cyclohydrolase 1 IMP RGD PMID:12855421 RGD:1601283 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gja5 gap junction protein, alpha 5 IMP RGD PMID:18046320 RGD:7207467 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gnas GNAS complex locus IMP RGD PMID:21895632 RGD:5509797 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Guca2b guanylate cyclase activator 2B ISO MGI:2679505 (MGI:2678878|PMID:14561709) RGD PMID:14561709 MGI:2678878 NCBI chr 5:138,695,591...138,697,641
Ensembl chr 5:138,695,591...138,697,641
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 IDA RGD PMID:15962106 RGD:1599364 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hrh3 histamine receptor H3 IMP RGD PMID:9050021 RGD:1626409 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Mkks McKusick-Kaufman syndrome ISO MGI:3526444 (MGI:3794515|PMID:18317593) RGD PMID:18317593 MGI:3794515 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Nos1 nitric oxide synthase 1 IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:15331368, PMID:21873635 RGD:1598375, RGD:13792537 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npy neuropeptide Y IMP RGD PMID:15699473 RGD:1357410 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:10651151 RGD:9835014 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IMP RGD PMID:18562099 RGD:2304105 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IMP RGD PMID:19015400 RGD:4108483 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pmch pro-melanin-concentrating hormone IDA RGD PMID:17045349 RGD:1642492 NCBI chr 7:28,655,206...28,656,522
Ensembl chr 7:28,654,733...28,657,522
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:15967866 RGD:1580222 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:9548392, PMID:3019921 RGD:10041048, RGD:10043185 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO (PMID:15841207) RGD PMID:15841207 NCBI chr 1:251,828,285...252,101,963
Ensembl chr 1:251,828,290...252,100,759
JBrowse link
G Rnpep arginyl aminopeptidase IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:3001599, PMID:21873635 RGD:2325950, RGD:13792537 NCBI chr13:52,092,863...52,124,006
Ensembl chr13:52,092,859...52,111,363
JBrowse link
G Scpep1 serine carboxypeptidase 1 ISO UniProtKB:P16675 (MGI:5573018|PMID:24586188) RGD PMID:24586188 MGI:5573018 NCBI chr10:76,230,371...76,263,866
Ensembl chr10:76,230,373...76,263,866
JBrowse link
G Snx5 sorting nexin 5 IMP RGD PMID:23195037 RGD:13508622 NCBI chr 3:138,378,032...138,397,944
Ensembl chr 3:138,378,202...138,397,870
JBrowse link
G Ucn urocortin IDA RGD PMID:15604589 RGD:1642785 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:16531985, PMID:12217424 RGD:2306837, RGD:2306871 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
G Uts2r urotensin 2 receptor IMP RGD PMID:16531985 RGD:2306837 NCBI chr10:110,364,291...110,365,451
Ensembl chr10:110,364,291...110,365,451
JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:19412173 RGD:2315485 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sod2 superoxide dismutase 2 ISO MGI:1857129|MGI:1857480 (MGI:3765405|PMID:16873728) RGD PMID:16873728 MGI:3765405 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 ISO MGI:1857123 (MGI:1342129|PMID:10425188) RGD PMID:10425188 MGI:1342129 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO MGI:2182739 (MGI:3694178|PMID:15998684) RGD PMID:15998684 MGI:3694178 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha ISO MGI:2445489 (MGI:2445452|PMID:11717154) RGD PMID:11717154 MGI:2445452 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO MGI:2387663 (MGI:2182494|PMID:12093905) RGD PMID:12093905 MGI:2182494 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
negative regulation of systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor IDA RGD PMID:9597368 RGD:1625365 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Ahr aryl hydrocarbon receptor ISO (MGI:3760685|PMID:14644620) RGD PMID:14644620 MGI:3760685 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arhgap42 Rho GTPase activating protein 42 ISO MGI:1096342 (MGI:5638847|PMID:24335996) RGD PMID:24335996 MGI:5638847 NCBI chr 8:7,210,999...7,446,215
Ensembl chr 8:7,213,822...7,426,611
JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 ISO MGI:3045473 (MGI:3794515|PMID:18317593) RGD PMID:18317593 MGI:3794515 NCBI chr 8:64,115,005...64,154,432
Ensembl chr 8:64,121,392...64,154,396
JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO (PMID:18364108) RGD PMID:18364108 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494
JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:22128087 RGD:6893560 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:7477349 RGD:70047 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Gpr37l1 G protein-coupled receptor 37-like 1 ISS
ISO
IEA
GO_REF:0000024
(MGI:6150990|PMID:29625592)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29625592 GO_REF:0000024, GO_REF:0000107, MGI:6150990 NCBI chr13:51,985,698...51,992,547
Ensembl chr13:51,985,684...51,992,693
JBrowse link
G Ier3 immediate early response 3 ISO MGI:3773690 (MGI:3772966|PMID:16166241) RGD PMID:16166241 MGI:3772966 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Kcnk6 potassium two pore domain channel subfamily K member 6 ISO MGI:2155245 (MGI:5499932|PMID:23637138) RGD PMID:23637138 MGI:5499932 NCBI chr 1:88,168,438...88,176,610
Ensembl chr 1:88,169,378...88,176,610
JBrowse link
G Kl Klotho IMP RGD PMID:20086041 RGD:10403068 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO MGI:3846431 (MGI:3846015|PMID:18524855) RGD PMID:18524855 MGI:3846015 NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
JBrowse link
G Nppa natriuretic peptide A IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:2136863, PMID:21873635 RGD:7247720, RGD:13792537 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:8289999, PMID:21403100, PMID:21873635 RGD:7247315, RGD:5685657, RGD:13792537 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:22211865 RGD:9727449 NCBI chr 3:175,982,313...176,046,345
Ensembl chr 3:175,885,894...176,046,345
JBrowse link
G Prcp prolylcarboxypeptidase IBA
ISO
PMID:21873635
MGI:4123993 (MGI:5009114|PMID:21297000)
RGD PMID:21297000, PMID:21873635 MGI:5009114, RGD:13792537 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Smtn smoothelin ISO MGI:3613293 (MGI:4437553|PMID:18678771) RGD PMID:18678771 MGI:4437553 NCBI chr14:83,755,141...83,776,871
Ensembl chr14:83,755,142...83,776,863
JBrowse link
G Tac1 tachykinin, precursor 1 ISO (PMID:12716968) RGD PMID:12716968 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tac4 tachykinin precursor 4 ISO (PMID:12716968) RGD PMID:12716968 NCBI chr10:83,081,168...83,089,487
Ensembl chr10:83,081,168...83,089,481
JBrowse link
G Tnf tumor necrosis factor IMP RGD PMID:7875478 RGD:14975128 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:27335281 RGD:13792700 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D ISO (MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:2656483 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IEA
ISO
IBA
GO_REF:0000107
MGI:1857120|MGI:87938 (MGI:1338641|PMID:10358009), (MGI:3608195|PMID:11641423)
PMID:21873635
Ensembl
RGD
PMID:10358009, PMID:11641423, PMID:21873635 GO_REF:0000107, MGI:1338641, MGI:3608195, RGD:13792537 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 IEA
ISO
IBA
GO_REF:0000107
MGI:1859675|MGI:87937 (MGI:1338641|PMID:10358009), (MGI:3608195|PMID:11641423)
PMID:21873635
Ensembl
RGD
PMID:10358009, PMID:11641423, PMID:21873635 GO_REF:0000107, MGI:1338641, MGI:3608195, RGD:13792537 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 IBA
ISO
PMID:21873635
(MGI:1338641|PMID:10358009)
RGD PMID:10358009, PMID:21873635 MGI:1338641, RGD:13792537 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological quality 4280
        regulation of blood pressure 219
          negative regulation of blood pressure 66
            negative regulation of blood pressure in other organism 0
            negative regulation of systemic arterial blood pressure + 30
Path 2
Term Annotations click to browse term
  biological_process 20020
    multicellular organismal process 9047
      system process 3456
        circulatory system process 579
          blood circulation 551
            regulation of blood pressure 219
              negative regulation of blood pressure 66
                negative regulation of blood pressure in other organism 0
                negative regulation of systemic arterial blood pressure + 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.