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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of ossification
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Accession:GO:0045778 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:exact_synonym: positive regulation of bone biosynthesis;   positive regulation of bone formation;   up regulation of ossification;   upregulation of ossification
 narrow_synonym: activation of ossification;   stimulation of ossification


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positive regulation of ossification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1643600
RGD:1624291
RGD:632977
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
G Nell1 neural EGFL like 1 JBrowse link 1 105,348,577 106,218,970 RGD:2314454
G Nipbl NIPBL, cohesin loading factor JBrowse link 2 57,508,830 57,676,197 RGD:1624291
G Oxt oxytocin/neurophysin I prepropeptide JBrowse link 3 123,106,694 123,107,534 RGD:2304114
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043372
RGD:10045950
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7207452
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:14397563
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1600115
RGD:1624291
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:1601657
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 JBrowse link 1 174,428,056 174,495,356 RGD:1624291
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:2304342
G Tacr1 tachykinin receptor 1 JBrowse link 4 113,247,236 113,416,139 RGD:2304342
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
RGD:1600115
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:1601663
G Tob2 transducer of ERBB2, 2 JBrowse link 7 123,079,520 123,088,240 RGD:1624291
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1624291
RGD:1600115
G Zbtb16 zinc finger and BTB domain containing 16 JBrowse link 8 52,980,226 53,146,765 RGD:1624291
RGD:1600115
positive regulation of bone mineralization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Acvr2a activin A receptor type 2A JBrowse link 3 32,947,901 33,034,598 RGD:1624291
RGD:1600115
G Acvr2b activin A receptor type 2B JBrowse link 8 128,087,308 128,126,776 RGD:1624291
RGD:1600115
G Adgrv1 adhesion G protein-coupled receptor V1 JBrowse link 2 8,926,843 9,504,455 RGD:1624291
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:1624291
RGD:1600115
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1600115
RGD:1624291
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 JBrowse link 7 41,114,606 41,223,138 RGD:1600115
RGD:1624291
G Atraid all-trans retinoic acid-induced differentiation factor JBrowse link 6 26,680,628 26,685,185 RGD:1624291
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1600115
RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:9068399
RGD:1624291
RGD:1600115
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Bmpr1b bone morphogenetic protein receptor type 1B JBrowse link 2 247,392,195 247,662,026 RGD:1624291
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1600115
RGD:1624291
G Cd276 Cd276 molecule JBrowse link 8 63,312,060 63,350,411 RGD:1624291
G Fam20c FAM20C, golgi associated secretory pathway kinase JBrowse link 12 17,913,771 17,972,733 RGD:1624291
G Fbn2 fibrillin 2 JBrowse link 18 53,068,495 53,272,254 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Fzd9 frizzled class receptor 9 JBrowse link 12 24,473,981 24,476,295 RGD:1624291
RGD:1600115
G Gpm6b glycoprotein m6b JBrowse link X 29,604,607 29,751,174 RGD:1600115
RGD:1624291
G Isg15 ISG15 ubiquitin-like modifier JBrowse link 5 173,624,862 173,629,124 RGD:1624291
G Kl Klotho JBrowse link 12 942,974 987,206 RGD:1600115
RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1600115
RGD:1624291
G Mia3 MIA SH3 domain ER export factor 3 JBrowse link 13 101,727,434 101,770,127 RGD:1624291
G Nell1 neural EGFL like 1 JBrowse link 1 105,348,577 106,218,970 RGD:1624291
RGD:1600115
G Osr1 odd-skipped related transcription factor 1 JBrowse link 6 35,314,431 35,321,458 RGD:1624291
G Osr2 odd-skipped related transciption factor 2 JBrowse link 7 74,047,820 74,055,096 RGD:1624291
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Pkdcc protein kinase domain containing, cytoplasmic JBrowse link 6 6,427,657 6,436,974 RGD:1624291
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1642474
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:7207452
RGD:1624291
RGD:7242906
G Ptn pleiotrophin JBrowse link 4 64,239,156 64,330,996 RGD:1600115
RGD:1624291
G Slc8a1 solute carrier family 8 member A1 JBrowse link 6 4,244,076 4,564,262 RGD:1624291
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:727387
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:1624291
RGD:1600115
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:1624291
RGD:1600115
G Tmem119 transmembrane protein 119 JBrowse link 12 48,598,498 48,605,704 RGD:1624291
RGD:13792537
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1624291
RGD:1600115
positive regulation of bone mineralization involved in bone maturation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn3 actinin alpha 3 JBrowse link 1 220,120,532 220,136,460 RGD:1624291
G Asxl2 ASXL transcriptional regulator 2 JBrowse link 6 27,835,346 27,919,285 RGD:1624291
positive regulation of osteoblast differentiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acvr1 activin A receptor type 1 JBrowse link 3 44,432,476 44,539,680 RGD:1624291
RGD:1600115
G Acvr2a activin A receptor type 2A JBrowse link 3 32,947,901 33,034,598 RGD:1624291
RGD:1600115
G Acvr2b activin A receptor type 2B JBrowse link 8 128,087,308 128,126,776 RGD:1624291
RGD:1600115
G Atp6ap1 ATPase H+ transporting accessory protein 1 JBrowse link X 156,407,973 156,415,053 RGD:1600115
RGD:1624291
G Atraid all-trans retinoic acid-induced differentiation factor JBrowse link 6 26,680,628 26,685,185 RGD:1624291
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1600115
RGD:1624291
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:1643600
RGD:1624291
RGD:1600115
RGD:2289011
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:2289027
RGD:1624291
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Bmpr1b bone morphogenetic protein receptor type 1B JBrowse link 2 247,392,195 247,662,026 RGD:1624291
G Bmpr2 bone morphogenetic protein receptor type 2 JBrowse link 9 66,568,074 66,683,019 RGD:1624291
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1624291
RGD:1600115
G Ccn4 cellular communication network factor 4 JBrowse link 7 107,695,227 107,723,759 RGD:1600115
RGD:1624291
G Cd276 Cd276 molecule JBrowse link 8 63,312,060 63,350,411 RGD:1624291
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:1624291
RGD:1600115
G Cebpb CCAAT/enhancer binding protein beta JBrowse link 3 164,424,502 164,425,933 RGD:1624291
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:1624291
G Clic1 chloride intracellular channel 1 JBrowse link 20 5,040,314 5,049,166 RGD:1624291
G Cthrc1 collagen triple helix repeat containing 1 JBrowse link 7 77,966,722 77,977,004 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Ctnnbip1 catenin, beta-interacting protein 1 JBrowse link 5 166,464,170 166,513,030 RGD:1624291
G Ddr2 discoidin domain receptor tyrosine kinase 2 JBrowse link 13 88,311,639 88,436,561 RGD:1624291
G Dlx5 distal-less homeobox 5 JBrowse link 4 32,387,741 32,392,085 RGD:1298882
G Fam20c FAM20C, golgi associated secretory pathway kinase JBrowse link 12 17,913,771 17,972,733 RGD:1624291
G Fbn2 fibrillin 2 JBrowse link 18 53,068,495 53,272,254 RGD:1624291
G Fbxo5 F-box protein 5 JBrowse link 1 42,461,277 42,467,646 RGD:1624291
G Ffar4 free fatty acid receptor 4 JBrowse link 1 256,786,124 256,804,156 RGD:1600115
RGD:1624291
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:1624291
G Gdf10 growth differentiation factor 10 JBrowse link 16 10,250,508 10,262,383 RGD:2316372
G Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 JBrowse link X 70,563,381 70,572,295 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1624291
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1624291
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1598452
RGD:1600115
RGD:1624291
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:1624291
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:1624291
RGD:1600115
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:1624291
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:1624291
RGD:1600115
G Jund JunD proto-oncogene, AP-1 transcription factor subunit JBrowse link 16 20,485,028 20,486,707 RGD:1624291
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:10003161
G Lrp3 LDL receptor related protein 3 JBrowse link 1 91,447,308 91,462,603 RGD:1624291
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:1624291
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:1624291
G Mef2c myocyte enhancer factor 2C JBrowse link 2 11,658,534 11,822,788 RGD:1600115
RGD:1624291
G Men1 menin 1 JBrowse link 1 221,704,394 221,710,343 RGD:1624291
G Mir210 microRNA 210 JBrowse link 1 214,208,355 214,208,464 RGD:1624291
G Mnda myeloid cell nuclear differentiation antigen JBrowse link 13 92,073,664 92,091,335 RGD:1624291
G Msx2 msh homeobox 2 JBrowse link 17 11,683,862 11,689,527 RGD:1624291
RGD:1600115
G Nell1 neural EGFL like 1 JBrowse link 1 105,348,577 106,218,970 RGD:1624291
RGD:1600115
G Npnt nephronectin JBrowse link 2 238,001,767 238,068,886 RGD:1624291
RGD:1600115
G Nppc natriuretic peptide C JBrowse link 9 93,731,436 93,735,636 RGD:1642298
G Pdlim7 PDZ and LIM domain 7 JBrowse link 17 9,653,510 9,668,715 RGD:632731
G Prkd1 protein kinase D1 JBrowse link 6 71,035,017 71,349,531 RGD:1624291
RGD:1600115
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:10043372
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:1600115
RGD:1624291
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 JBrowse link 1 174,428,056 174,495,356 RGD:1624291
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:1624291
G Smad1 SMAD family member 1 JBrowse link 19 32,182,942 32,248,694 RGD:1624291
RGD:1600115
G Smad5 SMAD family member 5 JBrowse link 17 8,307,448 8,336,996 RGD:1624291
G Sox11 SRY-box transcription factor 11 JBrowse link 6 46,629,967 46,631,988 RGD:1624291
RGD:1600115
G Suco SUN domain containing ossification factor JBrowse link 13 79,736,485 79,801,133 RGD:1600115
RGD:1624291
G Tmem119 transmembrane protein 119 JBrowse link 12 48,598,498 48,605,704 RGD:1624291
RGD:13792537
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1624291
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:1624291
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:1624291
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1624291
RGD:1600115
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1624291
G Zhx3 zinc fingers and homeoboxes 3 JBrowse link 3 156,759,820 156,868,173 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    multicellular organismal process 8952
      ossification 425
        positive regulation of ossification 106
          positive regulation of bone mineralization + 45
          positive regulation of osteoblast differentiation + 69
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of multicellular organismal process 3443
          regulation of ossification 238
            positive regulation of ossification 106
              positive regulation of bone mineralization + 45
              positive regulation of osteoblast differentiation + 69
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.