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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of heart contraction
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Accession:GO:0045823 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of heart contraction.
Synonyms:exact_synonym: positive regulation of cardiac contraction;   up regulation of heart contraction;   upregulation of heart contraction
 narrow_synonym: activation of heart contraction;   stimulation of heart contraction


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positive regulation of heart contraction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:15840637 RGD:1598741 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Apln apelin IMP PMID:26611206 UniProt PMID:26611206 RGD:11534624 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 ISO MGI:MGI:2451290 (MGI:MGI:1337471|PMID:10360172) RGD PMID:10360172 MGI:MGI:1337471 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Glp1r glucagon-like peptide 1 receptor IDA RGD PMID:12093887 RGD:625448 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO (MGI:MGI:4829580|PMID:20516643) RGD PMID:20516643 MGI:MGI:4829580 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Hrc histidine rich calcium binding protein ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G LOC100912649 uncharacterized LOC100912649 IMP PMID:26611206 UniProt PMID:26611206 RGD:11534624
G Nkx2-5 NK2 homeobox 5 ISO
IEA
(MGI:MGI:3829107|PMID:18689573)
GO_REF:0000107
RGD
Ensembl
PMID:18689573 GO_REF:0000107, MGI:MGI:3829107 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO
ISS
(PMID:15896309)
GO_REF:0000024
RGD
UniProt
PMID:15896309 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde4d phosphodiesterase 4D IC PMID:19801680 BHF-UCL PMID:19801680 RGD:7327160 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
positive regulation of atrial cardiac muscle cell action potential term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23954346 RGD:10003031 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
positive regulation of cardiac muscle cell contraction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H IMP RGD PMID:19443576 RGD:7205486 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
positive regulation of cardiac muscle contraction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 ISO
IEA
(MGI:MGI:2181229|PMID:12075344)
GO_REF:0000107
RGD
Ensembl
PMID:12075344 GO_REF:0000107, MGI:MGI:2181229 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adra1a adrenoceptor alpha 1A IMP PMID:19011682 BHF-UCL PMID:19011682 RGD:5688340 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Ccn2 cellular communication network factor 2 IMP RGD PMID:19707545 RGD:2314476 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Chga chromogranin A IDA PMID:22459152 UniProt PMID:22459152 RGD:6906968 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IEP RGD PMID:21620734 RGD:5686387 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO
IEA
(PMID:19646991)
GO_REF:0000107
RGD
Ensembl
PMID:19646991 GO_REF:0000107 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Nppa natriuretic peptide A ISO (PMID:19646991) RGD PMID:19646991 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO (MGI:MGI:3836877|PMID:19127022), (MGI:MGI:5009116|PMID:21291891) RGD PMID:19127022, PMID:21291891 MGI:MGI:3836877, MGI:MGI:5009116 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Smtn smoothelin ISO MGI:MGI:3613292|MGI:MGI:3613293 (MGI:MGI:4437553|PMID:18678771) RGD PMID:18678771 MGI:MGI:4437553 NCBI chr14:83,755,141...83,776,871
Ensembl chr14:83,755,142...83,776,863
JBrowse link
G Ucn urocortin IDA RGD PMID:19460778 RGD:5508168 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
positive regulation of heart rate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2681791 (MGI:MGI:3653129|PMID:16626672) RGD PMID:16626672 MGI:MGI:3653129 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adm adrenomedullin IDA
ISO
(PMID:18434369) RGD PMID:18434369, PMID:19520650 RGD:2325635 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adra1a adrenoceptor alpha 1A IMP RGD PMID:22040923 RGD:5688308 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:9089896 RGD:5129112 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IDA RGD PMID:12686462 RGD:13800918 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:18339407 RGD:2300339 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:20060787 RGD:5130949 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Edn1 endothelin 1 ISO (PMID:2649896) RGD PMID:2649896 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 ISO
IEA
(PMID:2649896)
GO_REF:0000107
RGD
Ensembl
PMID:2649896 GO_REF:0000107 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Edn3 endothelin 3 ISO (PMID:2649896) RGD PMID:2649896 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO (MGI:MGI:5629781|PMID:25557619) RGD PMID:25557619 MGI:MGI:5629781 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO MGI:MGI:3574394 (MGI:MGI:3574376|PMID:15297376) RGD PMID:15297376 MGI:MGI:3574376 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hrc histidine rich calcium binding protein ISO UniProtKB:B9EIW1 (PMID:24125847) RGD PMID:24125847 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO
IEA
(PMID:19646991)
GO_REF:0000107
RGD
Ensembl
PMID:19646991 GO_REF:0000107 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Nmu neuromedin U IDA PMID:11853869 UniProt PMID:11853869 RGD:13461753 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Nppa natriuretic peptide A ISO (PMID:19646991) RGD PMID:19646991 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:25844489 RGD:13524517 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Ryr2 ryanodine receptor 2 IEA
ISO
GO_REF:0000107
MGI:MGI:2183509|MGI:MGI:3713774 (MGI:MGI:2182484|PMID:12089338), (MGI:MGI:3713015|PMID:17431507)
Ensembl
RGD
PMID:12089338, PMID:17431507 GO_REF:0000107, MGI:MGI:2182484, MGI:MGI:3713015 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 ISO (MGI:MGI:5294533|PMID:19796257) RGD PMID:19796257 MGI:MGI:5294533 NCBI chr 8:44,136,413...44,159,011
Ensembl chr 8:44,136,496...44,159,010
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 IMP RGD PMID:17259145 RGD:6484226 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Sirt1 sirtuin 1 IMP RGD PMID:22113495 RGD:7240568 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO (MGI:MGI:5584094|PMID:23361868) RGD PMID:23361868 MGI:MGI:5584094 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Tacr3 tachykinin receptor 3 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 2:240,021,152...240,118,971
Ensembl chr 2:240,021,152...240,118,971
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:23954346 RGD:10003031 NCBI chr 1:101,293,300...101,323,484
Ensembl chr 1:101,293,409...101,323,960
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:18597948, PMID:12217424 RGD:2306810, RGD:2306871 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
positive regulation of heart rate by epinephrine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpm1 tropomyosin 1 ISO
IEA
(MGI:MGI:3802907|PMID:17556658)
GO_REF:0000107
RGD
Ensembl
PMID:17556658 GO_REF:0000107, MGI:MGI:3802907 NCBI chr 8:72,814,737...72,841,496
Ensembl chr 8:72,814,740...72,842,228
JBrowse link
positive regulation of heart rate by epinephrine-norepinephrine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO
IBA
MGI:MGI:104774 (MGI:MGI:2664013|PMID:12782680)
PMID:21873635
RGD PMID:12782680, PMID:21873635 MGI:MGI:2664013, RGD:13792537 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B ISO
IBA
MGI:MGI:104773 (MGI:MGI:2664013|PMID:12782680)
PMID:21873635
RGD PMID:12782680, PMID:21873635 MGI:MGI:2664013, RGD:13792537 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adrb1 adrenoceptor beta 1 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
MGI:MGI:1857120 (MGI:MGI:1338641|PMID:10358009), (MGI:MGI:82113|PMID:8693001)
Ensembl
RGD
PMID:8693001, PMID:10358009, PMID:21873635 GO_REF:0000107, MGI:MGI:1338641, MGI:MGI:82113, RGD:13792537 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO
IEA
MGI:MGI:1888407 (MGI:MGI:3531222|PMID:10942027)
GO_REF:0000107
RGD
Ensembl
PMID:10942027 GO_REF:0000107, MGI:MGI:3531222 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
positive regulation of the force of heart contraction by epinephrine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IDA RGD PMID:19133992 RGD:5129126 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
positive regulation of the force of heart contraction by epinephrine-norepinephrine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISO MGI:MGI:104774 (MGI:MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:MGI:2656483 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B ISO MGI:MGI:104773 (MGI:MGI:2656483|PMID:12595294) RGD PMID:12595294 MGI:MGI:2656483 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adrb1 adrenoceptor beta 1 IEA
ISO
GO_REF:0000107
MGI:MGI:1857120 (MGI:MGI:82113|PMID:8693001), (MGI:MGI:84440|PMID:7761854)
Ensembl
RGD
PMID:7761854, PMID:8693001 GO_REF:0000107, MGI:MGI:82113, MGI:MGI:84440 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
positive regulation of the force of heart contraction by norepinephrine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IDA RGD PMID:19133992 RGD:5129126 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf207 ring finger protein 207 ISO (PMID:25281747) RGD PMID:25281747 NCBI chr 5:169,486,253...169,500,451
Ensembl chr 5:169,486,257...169,499,268
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.