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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching


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negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp3 poly (ADP-ribose) polymerase family, member 3 JBrowse link 8 115,173,440 115,179,543 RGD:1600115
RGD:1624291
negative regulation of isotype switching to IgA isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Da2-19 uncharacterized LOC302729 JBrowse link X 48,196,789 48,213,506 RGD:1600115
G Thoc1 THO complex 1 JBrowse link 18 1,142,540 1,177,084 RGD:1624291
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
RGD:1600115
G Foxp3 forkhead box P3 JBrowse link X 15,753,175 15,768,648 RGD:1624291
RGD:1600115
G Ndfip1 Nedd4 family interacting protein 1 JBrowse link 18 31,574,759 31,625,286 RGD:1624291
RGD:1600115

Term paths to the root
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Term Annotations click to browse term
  biological_process 19245
    developmental process 6597
      negative regulation of developmental process 1087
        negative regulation of isotype switching 6
          negative regulation of isotype switching to IgA isotypes 2
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      cellular metabolic process 10461
        cellular aromatic compound metabolic process 5385
          nucleobase-containing compound metabolic process 5163
            nucleic acid metabolic process 4679
              DNA metabolic process 862
                DNA recombination 303
                  somatic cell DNA recombination 72
                    somatic diversification of immune receptors via germline recombination within a single locus 72
                      somatic recombination of immunoglobulin gene segments 60
                        somatic recombination of immunoglobulin genes involved in immune response 55
                          isotype switching 55
                            regulation of isotype switching 40
                              negative regulation of isotype switching 6
                                negative regulation of isotype switching to IgA isotypes 2
                                negative regulation of isotype switching to IgD isotypes 0
                                negative regulation of isotype switching to IgE isotypes 3
                                negative regulation of isotype switching to IgG isotypes 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.