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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of isotype switching
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Accession:GO:0045829 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: down regulation of isotype switching;   downregulation of isotype switching;   negative regulation of class switch recombination;   negative regulation of class switching;   negative regulation of isotype switch recombination
 narrow_synonym: inhibition of isotype switching


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negative regulation of isotype switching term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PARP3 poly(ADP-ribose) polymerase family member 3 JBrowse link 13 34,075,807 34,084,384 RGD:14298760
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCL6 BCL6 transcription repressor JBrowse link 13 125,377,247 125,401,328 RGD:14298760
G FOXP3 forkhead box P3 JBrowse link X 43,303,777 43,328,164 RGD:14298760
G NDFIP1 Nedd4 family interacting protein 1 JBrowse link 2 143,688,946 143,734,523 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15162
    developmental process 4236
      negative regulation of developmental process 676
        negative regulation of isotype switching 4
          negative regulation of isotype switching to IgA isotypes 0
          negative regulation of isotype switching to IgD isotypes 0
          negative regulation of isotype switching to IgE isotypes 3
          negative regulation of isotype switching to IgG isotypes 0
Path 2
Term Annotations click to browse term
  biological_process 15162
    metabolic process 9321
      cellular metabolic process 8405
        cellular aromatic compound metabolic process 4363
          nucleobase-containing compound metabolic process 4222
            nucleic acid metabolic process 3865
              DNA metabolic process 659
                DNA recombination 229
                  somatic cell DNA recombination 53
                    somatic diversification of immune receptors via germline recombination within a single locus 53
                      somatic recombination of immunoglobulin gene segments 45
                        somatic recombination of immunoglobulin genes involved in immune response 40
                          isotype switching 40
                            regulation of isotype switching 32
                              negative regulation of isotype switching 4
                                negative regulation of isotype switching to IgA isotypes 0
                                negative regulation of isotype switching to IgD isotypes 0
                                negative regulation of isotype switching to IgE isotypes 3
                                negative regulation of isotype switching to IgG isotypes 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.