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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of isotype switching
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Accession:GO:0045830 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: positive regulation of class switch recombination;   positive regulation of class switching;   positive regulation of isotype switch recombination;   up regulation of isotype switching;   upregulation of isotype switching
 narrow_synonym: activation of isotype switching;   stimulation of isotype switching


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positive regulation of isotype switching term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 ISO (MGI:MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:MGI:5009766 NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705
JBrowse link
G Exosc6 exosome component 6 ISO (MGI:MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:MGI:5009766 NCBI chr19:43,190,879...43,193,164
Ensembl chr19:43,191,390...43,192,208
JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific ISS
ISO
GO_REF:0000024
(MGI:MGI:6393148|PMID:31806351)
UniProt
RGD
PMID:31806351 GO_REF:0000024, MGI:MGI:6393148 NCBI chr 4:119,841,088...119,864,115
Ensembl chr 4:119,815,139...119,864,114
JBrowse link
G Kmt5b lysine methyltransferase 5B ISS
ISO
GO_REF:0000024
(MGI:MGI:6370097|PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024, MGI:MGI:6370097 NCBI chr 1:219,000,844...219,050,211
Ensembl chr 1:219,000,844...219,050,211
JBrowse link
G Kmt5c lysine methyltransferase 5C ISS
ISO
GO_REF:0000024
(MGI:MGI:6370097|PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024, MGI:MGI:6370097 NCBI chr 1:72,666,662...72,674,271
Ensembl chr 1:72,666,665...72,674,271
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255
JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:MGI:4821506 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326
JBrowse link
G Rif1 replication timing regulatory factor 1 ISO (MGI:MGI:5468036|PMID:23306439), (MGI:MGI:5476381|PMID:23333305), (MGI:MGI:5490831|PMID:23333306) RGD PMID:23306439, PMID:23333305, PMID:23333306 MGI:MGI:5468036, MGI:MGI:5476381, MGI:MGI:5490831 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
JBrowse link
G Shld1 shieldin complex subunit 1 ISO
IBA
(PMID:29656893)
PMID:21873635
RGD PMID:29656893, PMID:21873635 RGD:13792537 NCBI chr 3:125,318,682...125,396,705
Ensembl chr 3:125,320,680...125,396,821
JBrowse link
G Shld2 shieldin complex subunit 2 ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:10,570,307...10,661,528
Ensembl chr16:10,570,314...10,661,528
JBrowse link
G Tfrc transferrin receptor ISO
ISS
(PMID:26642240)
GO_REF:0000024
RGD
UniProt
PMID:26642240 GO_REF:0000024 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 ISO (PMID:23345425), (PMID:23760478)
(MGI:MGI:3041657|PMID:15077110), (MGI:MGI:3046005|PMID:15159415)
RGD PMID:15077110, PMID:15159415, PMID:23345425, PMID:23760478 MGI:MGI:3041657, MGI:MGI:3046005 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 ISO (MGI:MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:MGI:3763508 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107, MGI:MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Msh2 mutS homolog 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107, MGI:MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 ISO (MGI:MGI:5462481|PMID:23241889) RGD PMID:23241889 MGI:MGI:5462481 NCBI chr14:82,119,210...82,196,501
Ensembl chr14:82,119,210...82,171,480
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
ISS
(PMID:14988498)
GO_REF:0000024
RGD
AgBase
PMID:14988498 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnfsf13 TNF superfamily member 13 ISO
IBA
(PMID:14988498)
PMID:21873635
MGI:MGI:3038886 (MGI:MGI:3037416|PMID:14988498)
RGD PMID:14988498, PMID:21873635 MGI:MGI:3037416, RGD:13792537 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 ISO (MGI:MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:MGI:3777853 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:3037416|PMID:14988498)
PMID:21873635
RGD PMID:14988498, PMID:21873635 MGI:MGI:3037416, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:MGI:107187 (MGI:MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:MGI:1345885 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:MGI:4127920 (MGI:MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:MGI:5763555 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649
JBrowse link
G Cd28 Cd28 molecule ISO
IEA
MGI:MGI:1857150 (MGI:MGI:62368|PMID:7688139)
GO_REF:0000107
RGD
Ensembl
PMID:7688139 GO_REF:0000107, MGI:MGI:62368 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd40 CD40 molecule ISO
IBA
(MGI:MGI:2670820|PMID:12882831)
PMID:21873635
RGD PMID:12882831, PMID:21873635 MGI:MGI:2670820, RGD:13792537 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Ifng interferon gamma ISO (MGI:MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:MGI:2670820 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 ISO MGI:MGI:1857191 (MGI:MGI:87443|PMID:1830926) RGD PMID:1830926 MGI:MGI:87443 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 ISO
IBA
(MGI:MGI:2670820|PMID:12882831), (MGI:MGI:3037416|PMID:14988498)
PMID:21873635
RGD PMID:12882831, PMID:14988498, PMID:21873635 MGI:MGI:2670820, MGI:MGI:3037416, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Mlh1 mutL homolog 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107, MGI:MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Msh2 mutS homolog 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107, MGI:MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 ISO (MGI:MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:MGI:5752090 NCBI chr 1:198,448,790...198,451,078
Ensembl chr 1:198,449,040...198,450,688
JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:MGI:5752090 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO MGI:MGI:2181288 (MGI:MGI:85031|PMID:9015183) RGD PMID:9015183 MGI:MGI:85031 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Tbx21 T-box transcription factor 21 ISO MGI:MGI:2180194 (MGI:MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:MGI:2670820 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    developmental process 6827
      positive regulation of developmental process 1474
        positive regulation of isotype switching 30
          positive regulation of isotype switching to IgA isotypes 6
          positive regulation of isotype switching to IgD isotypes 0
          positive regulation of isotype switching to IgE isotypes + 4
          positive regulation of isotype switching to IgG isotypes 13
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        cellular aromatic compound metabolic process 5715
          nucleobase-containing compound metabolic process 5489
            nucleic acid metabolic process 4985
              DNA metabolic process 923
                DNA recombination 335
                  somatic cell DNA recombination 76
                    somatic diversification of immune receptors via germline recombination within a single locus 76
                      somatic recombination of immunoglobulin gene segments 63
                        somatic recombination of immunoglobulin genes involved in immune response 57
                          isotype switching 57
                            regulation of isotype switching 42
                              positive regulation of isotype switching 30
                                positive regulation of isotype switching to IgA isotypes 6
                                positive regulation of isotype switching to IgD isotypes 0
                                positive regulation of isotype switching to IgE isotypes + 4
                                positive regulation of isotype switching to IgG isotypes 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.