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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of lipid metabolic process
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Accession:GO:0045833 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
Synonyms:exact_synonym: down regulation of lipid metabolic process;   downregulation of lipid metabolic process;   negative regulation of lipid metabolism
 narrow_synonym: inhibition of lipid metabolic process


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negative regulation of lipid metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
G Apoc2 apolipoprotein C2 JBrowse link 1 80,589,023 80,593,991 RGD:1624291
RGD:1600115
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
RGD:1600115
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:4891166
RGD:1624291
RGD:1600115
negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc27a4 solute carrier family 27 member 4 JBrowse link 3 8,363,937 8,376,858 RGD:1600115
negative regulation of androgen biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:1624291
RGD:1600115
G Malrd1 MAM and LDL receptor class A domain containing 1 JBrowse link 17 82,430,836 83,156,696 RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Prox1 prospero homeobox 1 JBrowse link 13 108,382,536 108,444,107 RGD:1624291
RGD:1600115
negative regulation of calcidiol 1-monooxygenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 JBrowse link 7 70,333,150 70,340,006 RGD:1624291
G Gfi1 growth factor independent 1 transcriptional repressor JBrowse link 14 3,058,035 3,073,332 RGD:1624291
RGD:1600115
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:1624291
RGD:1600115
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 JBrowse link 9 53,110,628 53,120,454 RGD:1624291
RGD:13792537
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 JBrowse link 7 3,242,991 3,246,085 RGD:1624291
RGD:13792537
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 JBrowse link 10 86,545,910 86,554,478 RGD:1624291
RGD:13792537
RGD:1600115
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1600115
RGD:1624291
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
RGD:10059686
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
RGD:1600115
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
RGD:1600115
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 17 63,107,152 63,107,469 RGD:1624291
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
negative regulation of cholesterol esterification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:1600115
RGD:14697729
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
RGD:1600115
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:4891166
RGD:1624291
RGD:1600115
negative regulation of fatty acid beta-oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:1624291
RGD:1600115
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
RGD:1600115
G Cnr1 cannabinoid receptor 1 JBrowse link 5 49,307,584 49,333,064 RGD:2314644
G Dbi diazepam binding inhibitor, acyl-CoA binding protein JBrowse link 13 36,147,667 36,156,076 RGD:2316274
G Plin5 perilipin 5 JBrowse link 9 10,956,013 10,961,782 RGD:1600115
RGD:1624291
negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Etfbkmt electron transfer flavoprotein subunit beta lysine methyltransferase JBrowse link 4 183,655,968 183,665,757 RGD:1624291
RGD:1600115
negative regulation of fatty acid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:1624291
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:1624291
RGD:1600115
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1600115
RGD:1624291
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1600115
RGD:13792537
RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:11059593
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:13792517
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
RGD:1600115
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
RGD:1600115
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
RGD:1600115
G Trib3 tribbles pseudokinase 3 JBrowse link 3 147,814,056 147,819,650 RGD:1624291
RGD:1600115
G Wdtc1 WD and tetratricopeptide repeats 1 JBrowse link 5 151,487,572 151,536,829 RGD:1624291
RGD:13792537
RGD:1600115
negative regulation of fatty acid metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:1624291
RGD:1600115
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:1624291
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:1624291
negative regulation of fatty acid oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:1624291
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:1624291
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:1624291
RGD:1600115
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 7 26,256,179 26,306,128 RGD:1600115
RGD:1624291
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:10400884
G Mir199a2 microRNA 199a-2 JBrowse link 13 80,125,487 80,125,596 RGD:1624291
G Sirt4 sirtuin 4 JBrowse link 12 46,862,358 46,876,593 RGD:1624291
RGD:1600115
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:1624291
RGD:1600115
negative regulation of lipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
G Asxl3 ASXL transcriptional regulator 3 JBrowse link 18 13,322,148 13,496,230 RGD:1600115
RGD:1624291
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
RGD:1600115
G Enho energy homeostasis associated JBrowse link 5 58,018,039 58,019,836 RGD:1624291
RGD:1600115
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:1600115
RGD:1624291
G LOC259246 alpha-2u globulin PGCL1 RGD:1600115
G Serpina12 serpin family A member 12 JBrowse link 6 127,696,501 127,711,238 RGD:1624291
RGD:1600115
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
negative regulation of lipid catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:1624291
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:1625243
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
RGD:1600115
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:1624291
RGD:1600115
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1624291
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:1624291
RGD:1600115
G Cidea cell death-inducing DFFA-like effector a JBrowse link 18 63,082,861 63,108,450 RGD:1624291
RGD:1600115
G Crtc3 CREB regulated transcription coactivator 3 JBrowse link 1 142,398,248 142,500,562 RGD:1624291
RGD:1600115
G Fmc1 formation of mitochondrial complex V assembly factor 1 JBrowse link 4 66,276,835 66,284,868 RGD:1624291
RGD:1600115
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2293508
G Hcar1 hydroxycarboxylic acid receptor 1 JBrowse link 12 38,145,177 38,146,232 RGD:1624291
G Hcar2 hydroxycarboxylic acid receptor 2 JBrowse link 12 38,160,464 38,161,546 RGD:8553927
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
RGD:1600115
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:1624291
G Pde3b phosphodiesterase 3B JBrowse link 1 183,892,841 184,078,071 RGD:1624291
RGD:1600115
G Plin1 perilipin 1 JBrowse link 1 141,458,907 141,470,927 RGD:1624291
G Plin5 perilipin 5 JBrowse link 9 10,956,013 10,961,782 RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
negative regulation of lipid kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha JBrowse link 13 110,033,550 110,077,946 RGD:1624291
RGD:1600115
negative regulation of lipoprotein lipid oxidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apod apolipoprotein D JBrowse link 11 72,705,204 72,726,263 RGD:1600115
RGD:1624291
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lpcat1 lysophosphatidylcholine acyltransferase 1 JBrowse link 1 32,379,431 32,429,917 RGD:1624291
RGD:1600115
negative regulation of phosphatidylcholine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
negative regulation of phosphatidylinositol 3-kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 JBrowse link 14 83,559,397 83,572,481 RGD:1600115
RGD:1624291
G Rubcn rubicon autophagy regulator JBrowse link 11 71,150,506 71,199,254 RGD:1624291
RGD:13792537
RGD:1600115
G Washc1 WASH complex subunit 1 JBrowse link 9 113,918,914 113,936,861 RGD:1600115
RGD:1624291
negative regulation of phosphatidylinositol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:1624291
RGD:1600115
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:1624291
RGD:1600115
negative regulation of phospholipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:14697729
RGD:1600115
G Slc27a1 solute carrier family 27 member 1 JBrowse link 16 19,997,823 20,016,193 RGD:1600115
RGD:13792537
RGD:1624291
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pibf1 progesterone immunomodulatory binding factor 1 JBrowse link 15 83,494,110 83,663,202 RGD:1624291
RGD:1600115
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:1624291
negative regulation of sphingolipid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
RGD:14697729
RGD:1600115
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:1624291
negative regulation of steroid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:2316921
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
RGD:1600115
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1624291
negative regulation of steroid hormone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:1624291
negative regulation of testosterone biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dkkl1 dickkopf like acrosomal protein 1 JBrowse link 1 101,205,426 101,210,675 RGD:1624291
RGD:1600115
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
negative regulation of triglyceride biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sik1 salt-inducible kinase 1 JBrowse link 20 10,670,747 10,680,279 RGD:1624291
RGD:1600115
negative regulation of triglyceride catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1600115
RGD:13792537
RGD:1624291
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 JBrowse link 17 42,085,027 42,131,344 RGD:1624291
RGD:1600115
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:6482711
G Plin5 perilipin 5 JBrowse link 9 10,956,013 10,961,782 RGD:1600115
RGD:1624291
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
negative regulation of triglyceride metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 JBrowse link 4 155,386,367 155,414,034 RGD:1624291
RGD:1600115
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
G Ccnc cyclin C JBrowse link 5 35,865,598 35,883,732 RGD:9590256
G Cdk8 cyclin-dependent kinase 8 JBrowse link 12 10,496,273 10,561,335 RGD:9590256
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8552990
negative regulation of vitamin D biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:1624291
RGD:1600115
G Snai2 snail family transcriptional repressor 2 JBrowse link 11 90,404,421 90,406,730 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19317
    metabolic process 11540
      negative regulation of metabolic process 3065
        negative regulation of lipid metabolic process 98
          negative regulation of fatty acid metabolic process + 29
          negative regulation of isoprenoid metabolic process + 2
          negative regulation of lipid biosynthetic process + 54
          negative regulation of lipid catabolic process + 27
          negative regulation of lipid kinase activity + 5
          negative regulation of lipoprotein lipid oxidation 1
          negative regulation of phospholipid metabolic process + 10
          negative regulation of steroid metabolic process + 26
          negative regulation of triglyceride metabolic process + 11
Path 2
Term Annotations click to browse term
  biological_process 19317
    biological regulation 13340
      regulation of biological process 12656
        regulation of metabolic process 6536
          regulation of primary metabolic process 5824
            regulation of lipid metabolic process 370
              negative regulation of lipid metabolic process 98
                negative regulation of fatty acid metabolic process + 29
                negative regulation of isoprenoid metabolic process + 2
                negative regulation of lipid biosynthetic process + 54
                negative regulation of lipid catabolic process + 27
                negative regulation of lipid kinase activity + 5
                negative regulation of lipoprotein lipid oxidation 1
                negative regulation of phospholipid metabolic process + 10
                negative regulation of steroid metabolic process + 26
                negative regulation of triglyceride metabolic process + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.