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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of mitotic metaphase/anaphase transition
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Accession:GO:0045841 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: down regulation of mitotic metaphase/anaphase transition;   downregulation of mitotic metaphase/anaphase transition
 narrow_synonym: inhibition of mitotic metaphase/anaphase transition


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negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO5 F-box protein 5 ISO (PMID:11988738), (PMID:16921029) UniProtKB PMID:11988738, PMID:16921029 NCBI chr 6:150,793,020...150,806,008
Ensembl chr 6:155,481,753...155,494,231
JBrowse link
G RAD21 RAD21 cohesin complex component ISO (MGI:MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:MGI:1340883 NCBI chr 8:113,520,456...113,549,339
Ensembl chr 8:116,063,503...116,092,421
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr16:69,516,728...69,522,419
Ensembl chr16:89,174,071...89,177,823
JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO (PMID:17227893) MGI PMID:17227893 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709
JBrowse link
G ATM ATM serine/threonine kinase ISO (PMID:11943150) UniProtKB PMID:11943150 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO (PMID:12805209) UniProtKB PMID:12805209 NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159
JBrowse link
G CENPE centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G IK IK cytokine ISO (PMID:22351768) UniProtKB PMID:22351768 NCBI chr 5:136,012,381...136,027,099
Ensembl chr 5:142,129,130...142,143,393
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member ISO (MGI:MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:MGI:3844372 NCBI chr 6:71,089,817...71,190,700
Ensembl chr 6:74,478,303...74,479,826
JBrowse link
G KLHL22 kelch like family member 22 ISO (PMID:23455478) UniProtKB PMID:23455478 Ensembl chr22:19,122,875...19,174,842 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 ISO (PMID:18981471) UniProt PMID:18981471 NCBI chr 7:2,070,299...2,502,471
Ensembl chr 7:2,187,104...2,601,328
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (PMID:18981471)
(MGI:MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745, PMID:18981471 MGI:MGI:1930685 NCBI chr 4:112,247,808...112,255,202
Ensembl chr 4:123,397,355...123,405,535
JBrowse link
G PLK1 polo like kinase 1 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779
JBrowse link
G PSMG2 proteasome assembly chaperone 2 ISO (MGI:MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:MGI:2388532 NCBI chr18:1,597,981...1,620,721
Ensembl chr18:16,713,534...16,735,531
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor ISO (MGI:MGI:5318128|PMID:22405274) UniProtKB PMID:22405274 MGI:MGI:5318128 NCBI chr17:52,627,335...52,768,926
Ensembl chr17:57,480,369...57,621,055
JBrowse link
G TPR translocated promoter region, nuclear basket protein ISO (PMID:20133940) UniProt PMID:20133940 NCBI chr 1:161,842,037...161,903,567
Ensembl chr 1:165,993,726...166,055,223
JBrowse link
G TTK TTK protein kinase ISO (MGI:MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:MGI:5608719 NCBI chr 6:77,887,382...77,925,737
Ensembl chr 6:81,158,143...81,196,478
JBrowse link
G ZNF207 zinc finger protein 207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chr17:24,405,632...24,425,868
Ensembl chr17:24,690,903...24,714,628
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chr 3:32,450,693...32,495,400
Ensembl chr 3:32,758,407...32,804,117
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chr2A:17,735,953...17,766,018
Ensembl chr2A:17,862,070...17,892,048
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chr 4:112,247,808...112,255,202
Ensembl chr 4:123,397,355...123,405,535
JBrowse link
G NDC80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chr18:11,666,099...11,711,456
Ensembl chr18:13,972,637...14,018,261
JBrowse link
G PCID2 PCI domain containing 2 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chr13:94,319,699...94,350,763
Ensembl chr13:113,388,251...113,419,251
JBrowse link
G TPR translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chr 1:161,842,037...161,903,567
Ensembl chr 1:165,993,726...166,055,223
JBrowse link
G XRCC3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chr11:67,186,653...67,193,102
Ensembl chr11:70,411,031...70,416,484
JBrowse link
G CCNB1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:44,826,103...44,836,832
Ensembl chr 5:46,394,362...46,405,332
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chr 9:91,519,179...91,707,469
Ensembl chr 9:119,868,015...120,055,608
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 Ensembl chr16:25,351,814...25,418,285 JBrowse link
G USP44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chr12:93,111,293...93,146,889
Ensembl chr12:96,503,794...96,536,094
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    cellular process 11665
      cell cycle process 1004
        negative regulation of cell cycle process 200
          negative regulation of mitotic nuclear division 37
            negative regulation of mitotic metaphase/anaphase transition 28
              mitotic spindle assembly checkpoint + 26
Path 2
Term Annotations click to browse term
  biological_process 12561
    cellular process 11665
      cellular component organization or biogenesis 5013
        cellular component organization 4933
          organelle organization 3053
            organelle fission 419
              nuclear division 374
                mitotic nuclear division 234
                  mitotic sister chromatid segregation 125
                    mitotic sister chromatid separation 43
                      regulation of mitotic sister chromatid separation 40
                        metaphase/anaphase transition of mitotic cell cycle 40
                          regulation of mitotic metaphase/anaphase transition 36
                            negative regulation of mitotic metaphase/anaphase transition 28
                              mitotic spindle assembly checkpoint + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.