ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of mitotic metaphase/anaphase transition
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Accession:GO:0045841 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: down regulation of mitotic metaphase/anaphase transition;   downregulation of mitotic metaphase/anaphase transition
 narrow_synonym: inhibition of mitotic metaphase/anaphase transition


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negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FBXO5 F-box protein 5 JBrowse link 6 155,481,767 155,494,689 RGD:9068941
G RAD21 RAD21 cohesin complex component JBrowse link 8 116,063,503 116,092,421 RGD:9068941
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDT1 chromatin licensing and DNA replication factor 1 JBrowse link 16 89,173,312 89,178,809 RGD:9068941
mitotic spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APC APC regulator of WNT signaling pathway JBrowse link 5 113,873,993 114,009,709 RGD:9068941
G ATM ATM serine/threonine kinase JBrowse link 11 106,584,228 106,728,457 RGD:9068941
G AURKB aurora kinase B JBrowse link 17 48,180,066 48,186,129 RGD:9068941
G BIRC5 baculoviral IAP repeat containing 5 JBrowse link 17 77,842,724 77,854,159 RGD:9068941
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase JBrowse link 2A 111,815,335 111,855,573 RGD:9068941
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B JBrowse link 15 37,350,826 37,410,661 RGD:9068941
G BUB3 BUB3 mitotic checkpoint protein JBrowse link 10 123,986,864 123,998,011 RGD:9068941
G CDC20 cell division cycle 20 JBrowse link 1 44,039,971 44,044,497 RGD:9068941
G CENPF centromere protein F JBrowse link 1 195,025,577 195,086,518 RGD:9068941
G IK IK cytokine JBrowse link 5 142,129,130 142,143,393 RGD:9068941
G KLHL22 kelch like family member 22 JBrowse link 22 19,126,658 19,174,839 RGD:9068941
G LOC106633912 pachytene checkpoint protein 2 homolog JBrowse link 16 52,638,786 52,640,515 RGD:9068941
G MAD1L1 mitotic arrest deficient 1 like 1 JBrowse link 7 2,187,104 2,604,168 RGD:9068941
G MAD2L1 mitotic arrest deficient 2 like 1 JBrowse link 4 123,397,355 123,405,535 RGD:9068941
G MAD2L2 mitotic arrest deficient 2 like 2 JBrowse link 1 11,654,963 11,671,364 RGD:9068941
G PLK1 polo like kinase 1 JBrowse link 16 23,928,773 23,940,779 RGD:9068941
G PSMG2 proteasome assembly chaperone 2 JBrowse link 18 16,713,534 16,735,521 RGD:9068941
G SPDL1 spindle apparatus coiled-coil protein 1 JBrowse link 5 171,710,108 171,729,148 RGD:9068941
G TERF1 telomeric repeat binding factor 1 JBrowse link 8 71,192,716 71,231,648 RGD:9068941
G TEX14 testis expressed 14, intercellular bridge forming factor JBrowse link 17 57,480,369 57,621,055 RGD:9068941
G TPR translocated promoter region, nuclear basket protein JBrowse link 1 165,993,726 166,055,223 RGD:9068941
G TTK TTK protein kinase JBrowse link 6 81,158,143 81,196,478 RGD:9068941
G ZNF207 zinc finger protein 207 JBrowse link 17 24,693,863 24,714,296 RGD:9068941
G ZW10 zw10 kinetochore protein JBrowse link 11 112,454,637 112,494,959 RGD:9068941
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 JBrowse link 3 32,758,407 32,804,117 RGD:9068941
G GEN1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 2A 17,861,948 17,892,048 RGD:9068941
G MAD2L1 mitotic arrest deficient 2 like 1 JBrowse link 4 123,397,355 123,405,535 RGD:9068941
G NDC80 NDC80 kinetochore complex component JBrowse link 18 13,972,637 14,018,261 RGD:9068941
G PCID2 PCI domain containing 2 JBrowse link 13 113,388,251 113,419,523 RGD:9068941
G TPR translocated promoter region, nuclear basket protein JBrowse link 1 165,993,726 166,055,223 RGD:9068941
G XRCC3 X-ray repair cross complementing 3 JBrowse link 14 104,131,908 104,146,133 RGD:9068941
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANAPC15 anaphase promoting complex subunit 15 JBrowse link 11 70,413,270 70,416,495 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 5 46,394,362 46,405,332 RGD:9068941
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 JBrowse link 9 119,867,654 120,055,608 RGD:9068941
G DUSP1 dual specificity phosphatase 1 JBrowse link 5 175,032,797 175,035,960 RGD:9068941
G LCMT1 leucine carboxyl methyltransferase 1 JBrowse link 16 25,352,488 25,418,285 RGD:9068941
G USP44 ubiquitin specific peptidase 44 JBrowse link 12 96,503,794 96,539,321 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15711
    cellular process 14392
      cell cycle process 1319
        cell cycle phase transition 592
          mitotic cell cycle phase transition 553
            metaphase/anaphase transition of mitotic cell cycle 56
              negative regulation of mitotic metaphase/anaphase transition 38
                mitotic spindle assembly checkpoint + 36
Path 2
Term Annotations click to browse term
  biological_process 15711
    cellular process 14392
      cellular component organization 6087
        organelle organization 3715
          organelle fission 445
            nuclear division 403
              mitotic nuclear division 264
                mitotic sister chromatid segregation 152
                  regulation of mitotic sister chromatid segregation 69
                    regulation of mitotic sister chromatid separation 58
                      metaphase/anaphase transition of mitotic cell cycle 56
                        regulation of mitotic metaphase/anaphase transition 53
                          negative regulation of mitotic metaphase/anaphase transition 38
                            mitotic spindle assembly checkpoint + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.