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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of mitotic metaphase/anaphase transition
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Accession:GO:0045841 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: down regulation of mitotic metaphase/anaphase transition;   downregulation of mitotic metaphase/anaphase transition
 narrow_synonym: inhibition of mitotic metaphase/anaphase transition


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negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO5 F-box protein 5 IDA (PMID:11988738), (PMID:16921029) UniProtKB PMID:11988738, PMID:16921029 NCBI chr 6:152,970,535...152,983,579
Ensembl chr 6:152,970,519...152,983,579
JBrowse link
G RAD21 RAD21 cohesin complex component IEA Ensembl GO_REF:0000107 NCBI chr 8:116,845,934...116,874,776
Ensembl chr 8:116,845,934...116,874,776
Ensembl chr 8:116,845,934...116,874,776
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 IMP (PMID:22581055) CAFA PMID:22581055 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway IMP (PMID:17227893) MGI PMID:17227893 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G ATM ATM serine/threonine kinase IMP (PMID:11943150) UniProtKB PMID:11943150 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G AURKB aurora kinase B IEA InterPro GO_REF:0000002 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 IMP (PMID:12805209) UniProtKB PMID:12805209 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,136
Ensembl chr15:40,161,023...40,221,136
JBrowse link
G BUB1B-PAK6 BUB1B-PAK6 readthrough IEA InterPro GO_REF:0000002 NCBI chr15:40,217,428...40,277,487
Ensembl chr15:40,218,500...40,264,890
Ensembl chr15:40,218,500...40,264,890
JBrowse link
G BUB3 BUB3 mitotic checkpoint protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:123,154,402...123,170,467
Ensembl chr10:123,154,402...123,170,467
JBrowse link
G CDC20 cell division cycle 20 TAS Reactome Reactome:R-HSA-69618 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
JBrowse link
G CENPE centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CENPF centromere protein F NAS (PMID:12974617) UniProtKB PMID:12974617 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,195...214,664,571
JBrowse link
G IK IK cytokine IMP (PMID:22351768) UniProtKB PMID:22351768 NCBI chr 5:140,647,818...140,662,480
Ensembl chr 5:140,647,058...140,662,480
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member ISO (MGI:MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:MGI:3844372 NCBI chr 6:73,362,658...73,364,171
Ensembl chr 6:73,362,658...73,364,171
JBrowse link
G KLHL22 kelch like family member 22 IMP
IBA
(PMID:23455478)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:23455478 NCBI chr22:20,441,519...20,497,305
Ensembl chr22:20,441,519...20,495,844
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 IEA
IBA
IDA
(PMID:21873635)
(PMID:18981471)
InterPro
GO_Central
UniProt
PMID:18981471, PMID:21873635 GO_REF:0000002 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 TAS
IBA
IDA
(PMID:21873635)
(PMID:18981471)
Reactome
GO_Central
UniProt
PMID:18981471, PMID:21873635 Reactome:R-HSA-69618 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 TAS (PMID:10366450) PINC PMID:10366450 NCBI chr 1:11,674,480...11,691,559
Ensembl chr 1:11,674,480...11,691,650
JBrowse link
G PLK1 polo like kinase 1 IMP (PMID:23455478) UniProtKB PMID:23455478 NCBI chr16:23,678,889...23,690,367
Ensembl chr16:23,677,656...23,690,367
JBrowse link
G PSMG2 proteasome assembly chaperone 2 IEA Ensembl GO_REF:0000107 NCBI chr18:12,658,738...12,725,740
Ensembl chr18:12,658,043...12,725,740
JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 IEA InterPro GO_REF:0000002 NCBI chr 5:169,583,661...169,604,778
Ensembl chr 5:169,583,636...169,604,778
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor ISS
IEA
IBA
(PMID:21873635) UniProtKB
InterPro
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000024 NCBI chr17:58,556,678...58,692,045
Ensembl chr17:58,556,678...58,692,055
JBrowse link
G TPR translocated promoter region, nuclear basket protein IMP (PMID:20133940) UniProt PMID:20133940 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 IMP (PMID:28553959) UniProtKB PMID:28553959 NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357
JBrowse link
G TTK TTK protein kinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:80,004,147...80,042,651
Ensembl chr 6:80,003,887...80,042,527
JBrowse link
G ZNF207 zinc finger protein 207 IMP
IBA
(PMID:24462186), (PMID:24462187)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:24462186, PMID:24462187 NCBI chr17:32,350,157...32,381,885
Ensembl chr17:32,350,117...32,381,886
JBrowse link
G ZW10 zw10 kinetochore protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:113,733,183...113,773,699
Ensembl chr11:113,733,187...113,773,735
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IMP (PMID:19229290) UniProtKB PMID:19229290 NCBI chr 3:32,525,974...32,570,858
Ensembl chr 3:32,525,974...32,570,858
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IMP (PMID:23108668) UniProtKB PMID:23108668 NCBI chr 2:17,753,687...17,788,946
Ensembl chr 2:17,753,858...17,788,946
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IMP (PMID:20870947) UniProtKB PMID:20870947 NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
JBrowse link
G NDC80 NDC80 kinetochore complex component IMP (PMID:25743205) UniProtKB PMID:25743205 NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
JBrowse link
G PCID2 PCI domain containing 2 IMP (PMID:20870947) UniProtKB PMID:20870947 NCBI chr13:113,165,002...113,209,467
Ensembl chr13:113,177,536...113,208,715
JBrowse link
G TPR translocated promoter region, nuclear basket protein IMP (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chr 1:186,311,652...186,375,253
Ensembl chr 1:186,311,652...186,375,693
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IMP (PMID:23108668) UniProtKB PMID:23108668 NCBI chr14:103,697,611...103,715,486
Ensembl chr14:103,697,609...103,715,504
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IEA
IBA
IMP
(PMID:21873635)
(PMID:21926987)
InterPro
GO_Central
UniProtKB
PMID:21873635, PMID:21926987 GO_REF:0000002 NCBI chr11:72,106,372...72,112,780
Ensembl chr11:72,106,378...72,112,780
JBrowse link
G CCNB1 cyclin B1 IMP (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IDA
IBA
(PMID:19282672)
(PMID:21873635)
UniProtKB
GO_Central
PMID:19282672, PMID:21873635 NCBI chr 9:120,388,875...120,580,167
Ensembl chr 9:120,388,869...120,580,170
JBrowse link
G DUSP1 dual specificity phosphatase 1 ISS UniProtKB GO_REF:0000024 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 IMP (PMID:17724024) MGI PMID:17724024 NCBI chr16:25,111,702...25,178,231
Ensembl chr16:25,111,731...25,178,231
JBrowse link
G USP44 ubiquitin specific peptidase 44 ISS UniProtKB GO_REF:0000024 NCBI chr12:95,516,560...95,551,529
Ensembl chr12:95,516,560...95,551,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    cellular process 17687
      cell cycle process 1501
        negative regulation of cell cycle process 364
          negative regulation of mitotic nuclear division 50
            negative regulation of mitotic metaphase/anaphase transition 40
              mitotic spindle assembly checkpoint + 38
Path 2
Term Annotations click to browse term
  biological_process 18670
    cellular process 17687
      cellular component organization or biogenesis 7146
        cellular component organization 6956
          organelle organization 4354
            organelle fission 543
              nuclear division 486
                mitotic nuclear division 321
                  mitotic sister chromatid segregation 170
                    mitotic sister chromatid separation 68
                      regulation of mitotic sister chromatid separation 65
                        metaphase/anaphase transition of mitotic cell cycle 62
                          regulation of mitotic metaphase/anaphase transition 59
                            negative regulation of mitotic metaphase/anaphase transition 40
                              mitotic spindle assembly checkpoint + 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.