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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of mitotic metaphase/anaphase transition
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Accession:GO:0045841 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: down regulation of mitotic metaphase/anaphase transition;   downregulation of mitotic metaphase/anaphase transition
 narrow_synonym: inhibition of mitotic metaphase/anaphase transition


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negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 ISO (PMID:11988738), (PMID:16921029) UniProtKB PMID:11988738, PMID:16921029 NCBI chrNW_004936489:5,589,621...5,602,221 JBrowse link
G Rad21 RAD21 cohesin complex component ISO (MGI:MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:MGI:1340883 NCBI chrNW_004936470:29,377,793...29,403,422 JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO (PMID:17227893) MGI PMID:17227893 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Atm ATM serine/threonine kinase ISO (PMID:11943150) UniProtKB PMID:11943150 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Birc5 baculoviral IAP repeat containing 5 ISO (PMID:12805209) UniProtKB PMID:12805209 NCBI chrNW_004936594:2,812,165...2,820,618 JBrowse link
G Cenpe centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Ik IK cytokine ISO (PMID:22351768) UniProtKB PMID:22351768 NCBI chrNW_004936531:9,589,035...9,601,266 JBrowse link
G Klhl22 kelch like family member 22 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936619:2,854,915...2,899,386 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO (PMID:18981471) UniProt PMID:18981471 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (PMID:18981471)
(MGI:MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745, PMID:18981471 MGI:MGI:1930685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Plk1 polo like kinase 1 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Psmg2 proteasome assembly chaperone 2 ISO (MGI:MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:MGI:2388532 NCBI chrNW_004936626:2,328,646...2,344,831 JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor ISO (MGI:MGI:5318128|PMID:22405274) UniProtKB PMID:22405274 MGI:MGI:5318128 NCBI chrNW_004936490:4,499,825...4,576,952 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:20133940) UniProt PMID:20133940 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Trip13 thyroid hormone receptor interactor 13 ISO (PMID:28553959) UniProtKB PMID:28553959 NCBI chrNW_004936815:734,029...745,381 JBrowse link
G Ttk TTK protein kinase ISO (MGI:MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:MGI:5608719 NCBI chrNW_004936510:10,176,968...10,213,483 JBrowse link
G Znf207 zinc finger protein 207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chrNW_004936538:2,514,772...2,541,198 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936493:13,157,114...13,182,797 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Pcid2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chrNW_004936472:440,440...464,116 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936621:1,462,441...1,474,937 JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chrNW_004936498:1,460,795...1,468,363 JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chrNW_004936487:8,900,375...9,081,547 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004936501:9,354,607...9,397,675 JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) UniProtKB PMID:21853124 MGI:MGI:5448515 NCBI chrNW_004936507:11,663,069...11,692,174 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11998
    cellular process 11174
      cell cycle process 973
        negative regulation of cell cycle process 192
          negative regulation of mitotic nuclear division 37
            negative regulation of mitotic metaphase/anaphase transition 28
              mitotic spindle assembly checkpoint + 26
Path 2
Term Annotations click to browse term
  biological_process 11998
    cellular process 11174
      cellular component organization or biogenesis 4921
        cellular component organization 4843
          organelle organization 3003
            organelle fission 414
              nuclear division 369
                mitotic nuclear division 234
                  mitotic sister chromatid segregation 125
                    mitotic sister chromatid separation 43
                      regulation of mitotic sister chromatid separation 40
                        metaphase/anaphase transition of mitotic cell cycle 40
                          regulation of mitotic metaphase/anaphase transition 36
                            negative regulation of mitotic metaphase/anaphase transition 28
                              mitotic spindle assembly checkpoint + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.