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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of mitotic metaphase/anaphase transition
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Accession:GO:0045842 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: up regulation of mitotic metaphase/anaphase transition;   upregulation of mitotic metaphase/anaphase transition
 narrow_synonym: activation of mitotic metaphase/anaphase transition;   stimulation of mitotic metaphase/anaphase transition


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positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc11 anaphase promoting complex subunit 11 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:109,774,779...109,785,877
Ensembl chr10:109,774,878...109,785,877
JBrowse link
G Anapc4 anaphase promoting complex subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:60,471,962...60,503,803
Ensembl chr14:60,471,962...60,503,803
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:39,209,134...39,242,696
Ensembl chr12:39,209,129...39,242,690
JBrowse link
G Anapc7 anaphase promoting complex subunit 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:39,613,898...39,641,999
Ensembl chr12:39,614,733...39,641,285
JBrowse link
G Cdc16 cell division cycle 16 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:81,493,355...81,516,493
Ensembl chr16:81,493,355...81,516,493
JBrowse link
G Cdc23 cell division cycle 23 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:27,430,924...27,452,569
Ensembl chr18:27,430,905...27,452,420
JBrowse link
G Cdc27 cell division cycle 27 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cenpe centromere protein E ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Cul3 cullin 3 IEA
ISO
GO_REF:0000107
(PMID:17543862)
Ensembl
RGD
PMID:17543862 GO_REF:0000107 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase ISO
ISS
(PMID:19502785)
GO_REF:0000024
RGD
UniProt
PMID:19502785 GO_REF:0000024 NCBI chr 7:99,677,295...99,900,765
Ensembl chr 7:99,677,290...99,900,764
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IEA
(PMID:20551165)
GO_REF:0000107
RGD
Ensembl
PMID:20551165 GO_REF:0000107 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cell cycle process 1210
        positive regulation of cell cycle process 275
          positive regulation of mitotic nuclear division 45
            positive regulation of mitotic metaphase/anaphase transition 12
              deactivation of mitotic spindle assembly checkpoint 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            organelle fission 500
              nuclear division 445
                mitotic nuclear division 283
                  mitotic sister chromatid segregation 158
                    mitotic sister chromatid separation 59
                      regulation of mitotic sister chromatid separation 56
                        metaphase/anaphase transition of mitotic cell cycle 55
                          regulation of mitotic metaphase/anaphase transition 52
                            positive regulation of mitotic metaphase/anaphase transition 12
                              deactivation of mitotic spindle assembly checkpoint 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.