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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of proteolysis
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Accession:GO:0045861 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
Synonyms:exact_synonym: down regulation of proteolysis;   downregulation of proteolysis;   negative regulation of peptidolysis
 narrow_synonym: inhibition of proteolysis


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negative regulation of proteolysis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO (PMID:18387192) BHF-UCL PMID:18387192 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G BAG6 BAG cochaperone 6 ISO (MGI:MGI:3774040|PMID:18056262) UniProtKB PMID:18056262 MGI:MGI:3774040 NCBI chr 6:31,300,126...31,313,829
Ensembl chr 6:32,190,037...32,204,321
JBrowse link
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO (PMID:18305109) UniProtKB PMID:18305109 NCBI chr 1:19,437,761...19,441,573
Ensembl chr 1:20,479,562...20,482,600
JBrowse link
G CDK5 cyclin dependent kinase 5 ISO (PMID:24548080) ParkinsonsUK-UCL PMID:24548080 NCBI chr 7:142,640,630...142,644,785
Ensembl chr 7:154,793,344...154,797,499
JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin ISO (MGI:MGI:1346962|PMID:10527801) MGI PMID:10527801 MGI:MGI:1346962
G CST3 cystatin C ISO (PMID:3488317) UniProtKB PMID:3488317 NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425
JBrowse link
G CSTA cystatin A ISO (PMID:3488317) UniProtKB PMID:3488317 NCBI chr 3:119,417,489...119,432,244
Ensembl chr 3:126,323,901...126,338,430
JBrowse link
G CSTB cystatin B ISO (PMID:3488317) UniProtKB PMID:3488317 NCBI chr21:30,030,359...30,032,899 JBrowse link
G F2 coagulation factor II, thrombin ISO (PMID:1695900) BHF-UCL PMID:1695900 NCBI chr11:46,669,925...46,690,391
Ensembl chr11:47,227,891...47,249,157
JBrowse link
G HDAC6 histone deacetylase 6 ISO (PMID:18356165) BHF-UCL PMID:18356165 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642
JBrowse link
G IDE insulin degrading enzyme ISO inhibits activity of the multicatalytic proteinase complex (proteasome) RGD PMID:9000694 RGD:1627643 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353
JBrowse link
G INS insulin ISO (PMID:3553851) BHF-UCL PMID:3553851 NCBI chr11:2,200,785...2,202,579
Ensembl chr11:2,218,117...2,231,666
JBrowse link
G KNG1 kininogen 1 ISO (PMID:3488317) UniProtKB
RGD
PMID:3356189, PMID:3488317 RGD:1600550 NCBI chr 3:183,751,598...183,778,655
Ensembl chr 3:192,219,462...192,245,149
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 ISO (MGI:MGI:3822255|PMID:18806227) BHF-UCL PMID:18806227 MGI:MGI:3822255 NCBI chr19:47,340,077...47,346,737
Ensembl chr19:56,243,124...56,250,024
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 ISO (MGI:MGI:3822255|PMID:18806227) BHF-UCL PMID:18806227 MGI:MGI:3822255 NCBI chr11:47,195,122...47,215,277
Ensembl chr11:47,748,353...47,768,672
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:15161606 RGD:1625251 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960
JBrowse link
G PLAT plasminogen activator, tissue type ISO (PMID:1695900) BHF-UCL PMID:1695900 NCBI chr 8:41,419,415...41,451,951
Ensembl chr 8:38,864,918...38,897,779
JBrowse link
G RAB23 RAB23, member RAS oncogene family ISO (MGI:MGI:3612806|PMID:16364285) MGI PMID:16364285 MGI:MGI:3612806 NCBI chr 6:56,744,948...56,780,187
Ensembl chr 6:58,375,559...58,411,107
JBrowse link
G SERPINA5 serpin family A member 5 ISO RGD PMID:16088033 RGD:1580291 NCBI chr14:75,205,446...75,217,114
Ensembl chr14:94,537,115...94,548,803
JBrowse link
G SERPINB10 serpin family B member 10 ISO RGD PMID:11986314 RGD:634009 NCBI chr18:57,262,514...57,289,744
Ensembl chr18:60,573,580...60,599,697
JBrowse link
G SERPINE2 serpin family E member 2 ISO PMID:17379830
(PMID:17379830), (PMID:3997857)
BHF-UCL PMID:3997857, PMID:17379830 RGD:8553298 NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040
JBrowse link
G SPINK5 serine peptidase inhibitor Kazal type 5 ISO (MGI:MGI:3055648|PMID:15466487) MGI PMID:15466487 MGI:MGI:3055648 NCBI chr 5:143,387,981...143,578,839
Ensembl chr 5:149,506,367...149,590,930
JBrowse link
G SPINK9 serine peptidase inhibitor Kazal type 9 ISO (MGI:MGI:3662793|PMID:16930550) MGI PMID:16930550 MGI:MGI:3662793 NCBI chr 5:143,746,900...143,766,766 JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:17532789 RGD:2290425 NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:17532789 RGD:2290425 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964
JBrowse link
G TM4SF20 transmembrane 4 L six family member 20 ISO (PMID:25310401), (PMID:27499293) UniProtKB PMID:25310401, PMID:27499293 NCBI chr2B:114,606,488...114,623,569 JBrowse link
G TP53 tumor protein p53 ISO (MGI:MGI:5468878|PMID:23277542) MGI PMID:23277542 MGI:MGI:5468878 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
inhibition of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARD16 caspase recruitment domain family member 16 ISO (PMID:11432859) UniProtKB PMID:11432859 NCBI chr11:99,981,854...99,985,839 JBrowse link
G CAST calpastatin ISO (PMID:2407243) CAFA PMID:2407243 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650
JBrowse link
G CST7 cystatin F ISO (MGI:MGI:5904382|PMID:28251676) MGI PMID:28251676 MGI:MGI:5904382 NCBI chr20:24,889,834...24,900,766
Ensembl chr20:25,237,251...25,248,364
JBrowse link
G LOC100969375 caspase recruitment domain-containing protein 8 ISO (PMID:11821383) UniProtKB PMID:11821383 NCBI chr19:45,204,735...45,256,481
Ensembl chr19:53,798,967...53,850,328
JBrowse link
G NOL3 nucleolar protein 3 ISO PMID:16639714
PMID:17292893
UniProt PMID:16639714, PMID:17292893 RGD:10047164, RGD:10047212 NCBI chr16:47,516,156...47,521,441 JBrowse link
inhibition of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L12 BCL2 like 12 ISO (PMID:22262180) UniProtKB PMID:22262180 NCBI chr19:46,679,749...46,688,539 JBrowse link
G FCMR Fc fragment of IgM receptor ISO (MGI:MGI:3576402|PMID:15632112) MGI PMID:15632112 MGI:MGI:3576402 NCBI chr 1:182,506,551...182,525,249
Ensembl chr 1:186,786,147...186,803,789
JBrowse link
G NOL3 nucleolar protein 3 ISO (PMID:15509781) UniProtKB PMID:15509781 NCBI chr16:47,516,156...47,521,441 JBrowse link
G XIAP X-linked inhibitor of apoptosis ISO (MGI:MGI:2681362|PMID:14623868) MGI PMID:14623868 MGI:MGI:2681362 NCBI chr  X:113,052,164...113,105,160
Ensembl chr  X:123,232,643...123,278,606
JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIN1 bridging integrator 1 ISO (MGI:MGI:5811968|PMID:27179792)
(PMID:27179792)
ARUK-UCL PMID:27179792 MGI:MGI:5811968 NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378
JBrowse link
G SORL1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:17855360), (PMID:21989385)
(PMID:16407538)
Alzheimers_University_of_Toronto PMID:16407538, PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432
JBrowse link
negative regulation of aspartic-type peptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NLRP7 NLR family pyrin domain containing 7 ISO (PMID:15817483) UniProtKB PMID:15817483 NCBI chr19:51,966,886...51,990,971
Ensembl chr19:60,662,184...60,677,844
JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSN2 casein beta ISO (PMID:12788072) CAFA PMID:12788072 NCBI chr 4:54,276,495...54,282,221
Ensembl chr 4:60,613,091...60,618,815
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066
JBrowse link
G HTT huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chr 4:3,215,081...3,388,587
Ensembl chr 4:3,128,718...3,283,730
JBrowse link
G IFI16 interferon gamma inducible protein 16 ISO (PMID:22046441) UniProtKB PMID:22046441 NCBI chr 1:134,364,706...134,405,910
Ensembl chr 1:138,152,328...138,203,424
JBrowse link
G LTF lactotransferrin ISO (PMID:12788072) CAFA PMID:12788072 NCBI chr 3:46,337,738...46,367,476
Ensembl chr 3:47,442,440...47,471,532
JBrowse link
G MT3 metallothionein 3 ISO (PMID:18554677) UniProtKB PMID:18554677 NCBI chr16:36,875,919...36,877,558 JBrowse link
G PCID2 PCI domain containing 2 ISO (PMID:20870947) UniProtKB PMID:20870947 NCBI chr13:94,319,699...94,350,763
Ensembl chr13:113,388,251...113,419,251
JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO (MGI:MGI:5294538|PMID:18977203) UniProtKB PMID:18977203 MGI:MGI:5294538 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G AKT2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) ISO (PMID:21215257) UniProtKB PMID:21215257 NCBI chr 7:31,524,933...31,538,602 JBrowse link
G ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 ISO (PMID:12754298) UniProtKB PMID:12754298 NCBI chr16:19,478,719...19,488,636 JBrowse link
G ARRB1 arrestin beta 1 ISO (MGI:MGI:4453294|PMID:19915011) UniProtKB PMID:19915011 MGI:MGI:4453294 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155
JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517
JBrowse link
G AVP arginine vasopressin ISO (PMID:18402937) UniProtKB PMID:18402937 NCBI chr20:3,169,094...3,172,900 JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO (PMID:12773388)
(PMID:9859993)
UniProtKB PMID:9859993, PMID:12773388 NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159
JBrowse link
G CARD16 caspase recruitment domain family member 16 ISO (PMID:16920334) UniProtKB PMID:16920334 NCBI chr11:99,981,854...99,985,839 JBrowse link
G CD44 CD44 molecule (Indian blood group) ISO (PMID:19047049) UniProtKB PMID:19047049 NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009
JBrowse link
G CDKN2D cyclin dependent kinase inhibitor 2D ISO (PMID:15750620) BHF-UCL PMID:15750620 NCBI chr19:10,118,302...10,120,957 JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO (MGI:MGI:3612311|PMID:16263940) MGI PMID:16263940 MGI:MGI:3612311 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045
JBrowse link
G CRYAB crystallin alpha B ISO (MGI:MGI:3617146|PMID:16439475) MGI PMID:16439475 MGI:MGI:3617146 NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272
JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO (PMID:16193064) UniProtKB PMID:16193064 NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked ISO (PMID:18846110) UniProtKB PMID:18846110 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837
JBrowse link
G DHCR24 24-dehydrocholesterol reductase ISO (PMID:11007892) UniProtKB PMID:11007892 NCBI chr 1:54,126,170...54,163,713
Ensembl chr 1:55,714,693...55,754,698
JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 ISO (PMID:10411904) UniProtKB PMID:10411904 NCBI chr16:3,351,825...3,381,914
Ensembl chr16:4,519,965...4,550,786
JBrowse link
G DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 ISO (PMID:11896048) UniProtKB PMID:11896048 NCBI chr 7:148,952,823...149,034,578
Ensembl chr 7:160,646,321...160,726,447
JBrowse link
G DPEP1 dipeptidase 1 ISO (PMID:20435919) UniProtKB PMID:20435919 NCBI chr16:70,365,900...70,392,377
Ensembl chr16:89,975,105...89,997,978
JBrowse link
G EP300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604
JBrowse link
G FABP1 fatty acid binding protein 1 ISO (PMID:16175609) UniProtKB PMID:16175609 NCBI chr2A:87,256,032...87,303,505
Ensembl chr2A:89,165,315...89,170,448
JBrowse link
G FNIP1 folliculin interacting protein 1 ISO (MGI:MGI:5444323|PMID:22709692) MGI PMID:22709692 MGI:MGI:5444323 NCBI chr 5:127,070,906...127,219,548
Ensembl chr 5:133,235,501...133,384,218
JBrowse link
G GPI glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chr19:31,301,469...31,355,362
Ensembl chr19:40,024,584...40,080,598
JBrowse link
G GPX1 glutathione peroxidase 1 ISO (PMID:12221075) BHF-UCL PMID:12221075 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826
JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chr16:37,210,170...37,221,961
Ensembl chr16:56,343,025...56,355,164
JBrowse link
G HGF hepatocyte growth factor ISO (PMID:20655899) BHF-UCL PMID:20655899 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811
JBrowse link
G IFI6 interferon alpha inducible protein 6 ISO (PMID:15685448) HGNC PMID:15685448 NCBI chr 1:26,929,129...26,935,205
Ensembl chr 1:27,972,866...27,978,890
JBrowse link
G IGBP1 immunoglobulin binding protein 1 ISO (PMID:17438131) UniProtKB PMID:17438131 NCBI chr  X:59,401,426...59,434,363
Ensembl chr  X:69,460,734...69,493,616
JBrowse link
G IGF1 insulin like growth factor 1 ISO PMID:17023532 BHF-UCL PMID:17023532 RGD:1600072 NCBI chr12:99,986,887...100,066,773 JBrowse link
G IL24 interleukin 24 ISO (MGI:MGI:3821693|PMID:18708357) MGI PMID:18708357 MGI:MGI:3821693 NCBI chr 1:182,500,680...182,507,098
Ensembl chr 1:186,779,207...186,785,928
JBrowse link
G IL6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G INTS1 integrator complex subunit 1 ISO (MGI:MGI:3722560|PMID:17544522) MGI PMID:17544522 MGI:MGI:3722560 NCBI chr 7:1,719,254...1,753,150
Ensembl chr 7:1,838,302...1,871,554
JBrowse link
G KLF4 Kruppel like factor 4 ISO (PMID:20551324) BHF-UCL PMID:20551324 NCBI chr 9:78,634,545...78,639,447
Ensembl chr 9:106,820,954...106,825,797
JBrowse link
G LAMP3 lysosomal associated membrane protein 3 ISO (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chr 3:180,152,363...180,193,223
Ensembl chr 3:188,324,660...188,363,268
JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO (PMID:12773388) UniProtKB PMID:12773388 NCBI chr 1:113,050,671...113,057,368
Ensembl chr 1:127,285,553...127,292,233
JBrowse link
G LOC100990437 NADPH--cytochrome P450 reductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr 7:68,035,021...68,105,934
Ensembl chr 7:82,364,418...82,437,530
JBrowse link
G MAP2K5 mitogen-activated protein kinase kinase 5 ISO PMID:20551324 BHF-UCL PMID:20551324 RGD:8553940 NCBI chr15:46,493,139...46,760,271
Ensembl chr15:64,761,394...65,029,655
JBrowse link
G MDM2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278
JBrowse link
G MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 ISO (MGI:MGI:5142343|PMID:21730291) UniProtKB PMID:21730291 MGI:MGI:5142343 NCBI chr 6:107,247,084...107,269,138
Ensembl chr 6:111,295,548...111,317,214
JBrowse link
G MRTFA myocardin related transcription factor A ISO (MGI:MGI:2183867|PMID:12019265) MGI PMID:12019265 MGI:MGI:2183867 NCBI chr22:21,314,829...21,536,673
Ensembl chr22:39,413,002...39,467,402
JBrowse link
G MT3 metallothionein 3 ISO (PMID:16387743) UniProtKB PMID:16387743 NCBI chr16:36,875,919...36,877,558 JBrowse link
G NAIP NLR family apoptosis inhibitory protein ISO (PMID:11896143) UniProtKB PMID:11896143 NCBI chr 5:44,345,623...44,401,358
Ensembl chr 5:45,920,125...45,973,937
JBrowse link
G NOL3 nucleolar protein 3 ISO PMID:19001025 UniProt PMID:19001025 RGD:8553292 NCBI chr16:47,516,156...47,521,441 JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 ISO (MGI:MGI:2667579|PMID:12815108) MGI PMID:12815108 MGI:MGI:2667579 NCBI chr12:36,703,903...36,740,211
Ensembl chr12:37,480,300...37,501,188
JBrowse link
G PAX2 paired box 2 ISO (PMID:10980123), (PMID:17357786) UniProtKB PMID:10980123, PMID:17357786 NCBI chr10:97,344,978...97,429,086
Ensembl chr10:100,822,676...100,904,028
JBrowse link
G PTGER2 prostaglandin E receptor 2 ISO (PMID:21716255) CAFA PMID:21716255 NCBI chr14:32,910,755...32,926,138
Ensembl chr14:51,195,381...51,209,686
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO (MGI:MGI:5474549|PMID:21716255) CAFA PMID:21716255 MGI:MGI:5474549 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519
JBrowse link
G PTMA prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chr2B:118,959,382...118,964,364 JBrowse link
G RAG1 recombination activating 1 ISO (MGI:MGI:3531056|PMID:15728238) MGI PMID:15728238 MGI:MGI:3531056 NCBI chr11:36,483,697...36,546,242
Ensembl chr11:36,412,420...36,422,904
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 ISO (PMID:18402937) UniProtKB PMID:18402937 NCBI chr 1:25,792,428...25,837,950
Ensembl chr 1:26,856,057...26,900,532
JBrowse link
G RPS6KA3 ribosomal protein S6 kinase A3 ISO (PMID:18402937) UniProtKB PMID:18402937 NCBI chr  X:12,772,368...12,893,062
Ensembl chr  X:20,133,898...20,251,244
JBrowse link
G SFN stratifin ISO (PMID:11574543) HGNC PMID:11574543 NCBI chr 1:26,126,212...26,127,761
Ensembl chr 1:27,182,834...27,183,580
JBrowse link
G SFRP2 secreted frizzled related protein 2 ISO (MGI:MGI:3702339|PMID:17251350) MGI PMID:17251350 MGI:MGI:3702339 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258
JBrowse link
G SH3RF1 SH3 domain containing ring finger 1 ISO (PMID:21586138) UniProtKB PMID:21586138 NCBI chr 4:161,319,093...161,495,917
Ensembl chr 4:173,394,739...173,567,096
JBrowse link
G SIAH2 siah E3 ubiquitin protein ligase 2 ISO (PMID:21586138) UniProtKB PMID:21586138 NCBI chr 3:147,759,375...147,781,639
Ensembl chr 3:155,332,751...155,354,139
JBrowse link
G SNCA synuclein alpha ISO (PMID:10818098) UniProtKB PMID:10818098 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO (PMID:19767770) UniProtKB PMID:19767770 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
G THBS1 thrombospondin 1 ISO (PMID:18653767) UniProtKB PMID:18653767 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
JBrowse link
G TNF tumor necrosis factor ISO (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381
JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 ISO (PMID:15735003) BHF-UCL PMID:15735003 NCBI chr12:118,025,599...118,028,045
Ensembl chr12:121,400,063...121,402,506
JBrowse link
G USP47 ubiquitin specific peptidase 47 ISO (PMID:19966869) UniProtKB PMID:19966869 NCBI chr11:12,009,770...12,127,425
Ensembl chr11:11,703,617...11,821,074
JBrowse link
G VEGFA vascular endothelial growth factor A ISO (PMID:18386220) UniProtKB PMID:18386220 NCBI chr 6:43,361,053...43,377,366
Ensembl chr 6:44,650,365...44,666,353
JBrowse link
G WNT9A Wnt family member 9A ISO (MGI:MGI:4368092|PMID:19422823) MGI PMID:19422823 MGI:MGI:4368092 NCBI chr 1:203,320,990...203,350,599
Ensembl chr 1:208,300,609...208,327,191
JBrowse link
G XIAP X-linked inhibitor of apoptosis ISO (PMID:11583623)
(MGI:MGI:2183141|PMID:12011074), (MGI:MGI:2183348|PMID:12153481)
UniProtKB
MGI
PMID:11583623, PMID:12011074, PMID:12153481 MGI:MGI:2183141, MGI:MGI:2183348 NCBI chr  X:113,052,164...113,105,160
Ensembl chr  X:123,232,643...123,278,606
JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAAP1 caspase activity and apoptosis inhibitor 1 ISO (PMID:21980415) UniProtKB PMID:21980415 NCBI chr 9:26,688,023...26,739,818
Ensembl chr 9:27,295,433...27,346,814
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO (PMID:22984561) CACAO PMID:22984561 NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
JBrowse link
G NLE1 notchless homolog 1 ISO (MGI:MGI:5468737|PMID:23231322) MGI PMID:23231322 MGI:MGI:5468737 NCBI chr17:21,643,865...21,654,169
Ensembl chr17:21,935,800...21,946,049
JBrowse link
G PARK7 Parkinsonism associated deglycase ISO (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G PIH1D1 PIH1 domain containing 1 ISO (PMID:21078300) UniProtKB PMID:21078300 NCBI chr19:46,459,855...46,465,882
Ensembl chr19:55,381,803...55,387,664
JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO (PMID:22984561) CACAO PMID:22984561 NCBI chr19:40,588,100...40,616,479
Ensembl chr19:49,197,341...49,222,561
Ensembl chr19:49,197,341...49,222,561
JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAK2 p21 (RAC1) activated kinase 2 ISO (PMID:21555521) UniProtKB PMID:21555521 NCBI chr 3:194,084,037...194,174,010
Ensembl chr 3:204,023,357...204,111,507
JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase ISO (PMID:15069192) UniProtKB PMID:15069192 NCBI chr17:21,696,808...21,779,878
Ensembl chr17:22,035,643...22,069,546
JBrowse link
G RNF34 ring finger protein 34 ISO (PMID:15069192) UniProtKB PMID:15069192 NCBI chr12:118,998,436...119,022,823 JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 ISO (PMID:18387192) BHF-UCL PMID:18387192 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756
JBrowse link
G CRB2 crumbs cell polarity complex component 2 ISO (PMID:20299451) UniProtKB PMID:20299451 NCBI chr 9:94,473,423...94,511,285
Ensembl chr 9:123,011,968...123,032,855
JBrowse link
G FETUB fetuin B ISO (MGI:MGI:5488517|PMID:23562279) UniProtKB PMID:23562279 MGI:MGI:5488517 NCBI chr 3:183,675,258...183,687,754
Ensembl chr 3:192,142,702...192,154,920
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase ISO (PMID:22832495) UniProtKB PMID:22832495 NCBI chr12:6,665,218...6,669,170
Ensembl chr12:6,583,895...6,587,729
JBrowse link
G RENBP renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chr  X:143,490,103...143,499,487
Ensembl chr  X:153,376,847...153,386,214
JBrowse link
G SERPINB1 serpin family B member 1 ISO (PMID:30692621) UniProt PMID:30692621 NCBI chr 6:2,655,244...2,664,074
Ensembl chr 6:2,758,173...2,766,650
JBrowse link
G SERPINB13 serpin family B member 13 ISO (PMID:12504904) UniProtKB PMID:12504904 NCBI chr18:56,946,828...56,958,702
Ensembl chr18:60,258,085...60,270,607
JBrowse link
G SERPINB6 serpin family B member 6 ISO (PMID:17761692) BHF-UCL PMID:17761692 NCBI chr 6:2,770,689...2,794,737
Ensembl chr 6:2,873,790...2,896,631
JBrowse link
G SERPINB8 serpin family B member 8 ISO (PMID:8530382) UniProtKB PMID:8530382 NCBI chr18:57,313,562...57,373,502
Ensembl chr18:60,634,206...60,669,118
JBrowse link
G SERPINB9 serpin family B member 9 ISO (PMID:21795594) UniProtKB PMID:21795594 NCBI chr 6:2,709,188...2,725,592
Ensembl chr 6:2,812,815...2,827,932
JBrowse link
G SERPINE1 serpin family E member 1 ISO (PMID:1695900) RGD
BHF-UCL
PMID:1695900, PMID:10717410 RGD:8547889 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 ISO (PMID:14511383) UniProtKB PMID:14511383 NCBI chr 5:132,372,283...132,890,168
Ensembl chr 5:138,512,523...138,797,416
JBrowse link
G SPOCK3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 ISO (PMID:11751414) UniProtKB PMID:11751414 NCBI chr 4:158,941,142...159,437,078
Ensembl chr 4:171,022,442...171,517,005
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO (PMID:3903517) UniProtKB PMID:3903517 NCBI chr  X:40,018,190...40,022,636
Ensembl chr  X:47,914,906...47,919,419
JBrowse link
G VTN vitronectin ISO (PMID:1695900) BHF-UCL PMID:1695900 NCBI chr17:28,403,813...28,407,202
Ensembl chr17:28,906,508...28,909,583
JBrowse link
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SGTA small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440
JBrowse link
G SVIP small VCP interacting protein ISO (PMID:17872946) UniProtKB PMID:17872946 NCBI chr11:22,828,321...22,837,536
Ensembl chr11:22,735,361...22,744,558
JBrowse link
G USP14 ubiquitin specific peptidase 14 ISO (PMID:19135427) ParkinsonsUK-UCL PMID:19135427 NCBI chr18:14,104,754...14,158,402
Ensembl chr18:17,745,733...17,797,070
JBrowse link
negative regulation of ERAD pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP11 aquaporin 11 ISO (MGI:MGI:3813160|PMID:18606867) UniProt PMID:18606867 MGI:MGI:3813160 NCBI chr11:72,653,721...72,673,698
Ensembl chr11:76,295,778...76,315,292
JBrowse link
G UBXN1 UBX domain protein 1 ISO (PMID:21135095) ParkinsonsUK-UCL PMID:21135095 NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404
JBrowse link
G USP25 ubiquitin specific peptidase 25 ISO (PMID:22590560) ParkinsonsUK-UCL PMID:22590560 NCBI chr21:2,468,993...2,618,200
Ensembl chr21:15,724,729...15,982,182
JBrowse link
negative regulation of membrane protein ectodomain proteolysis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL10 interleukin 10 ISO (PMID:18383040) BHF-UCL PMID:18383040 NCBI chr 1:182,369,234...182,374,207
Ensembl chr 1:186,648,289...186,653,371
JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 ISO (PMID:12207026) BHF-UCL PMID:12207026 NCBI chr 9:80,528,896...80,651,629
Ensembl chr 9:108,699,761...108,787,464
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO (PMID:12714508) UniProtKB PMID:12714508 NCBI chr  X:40,018,190...40,022,636
Ensembl chr  X:47,914,906...47,919,419
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO (PMID:18383040) BHF-UCL PMID:18383040 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964
JBrowse link
negative regulation of metalloendopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RECK reversion inducing cysteine rich protein with kazal motifs ISO (PMID:18194466)
(MGI:MGI:5659805|PMID:24812324)
UniProt
BHF-UCL
PMID:18194466, PMID:24812324 MGI:MGI:5659805 NCBI chr 9:35,886,741...35,974,133
Ensembl chr 9:36,699,631...36,774,116
JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO (MGI:MGI:5659805|PMID:24812324) BHF-UCL PMID:24812324 MGI:MGI:5659805 NCBI chr22:13,811,297...13,872,799
Ensembl chr22:31,662,562...31,723,964
JBrowse link
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PICALM phosphatidylinositol binding clathrin assembly protein ISO (MGI:MGI:5432454|PMID:22539346) Alzheimers_University_of_Toronto PMID:22539346 MGI:MGI:5432454 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684
JBrowse link
G SORL1 sortilin related receptor 1 ISO (MGI:MGI:3801250|PMID:18362153)
(PMID:17855360), (PMID:21989385)
Alzheimers_University_of_Toronto PMID:17855360, PMID:18362153, PMID:21989385 MGI:MGI:3801250 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432
JBrowse link
negative regulation of metallopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO (PMID:9573338) UniProtKB PMID:9573338 NCBI chr  X:40,018,190...40,022,636
Ensembl chr  X:47,914,906...47,919,419
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO (PMID:9573338) UniProtKB PMID:9573338 NCBI chr17:72,928,692...73,001,892
Ensembl chr17:78,476,807...78,495,649
JBrowse link
negative regulation of peptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAST calpastatin ISO (MGI:MGI:5295525|PMID:21849499) MGI PMID:21849499 MGI:MGI:5295525 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650
JBrowse link
G CST3 cystatin C ISO (PMID:18256700), (PMID:6203523), (PMID:7890620) ARUK-UCL PMID:6203523, PMID:7890620, PMID:18256700 NCBI chr20:23,583,043...23,587,399
Ensembl chr20:23,935,942...23,940,425
JBrowse link
G CST7 cystatin F ISO (MGI:MGI:6294189|PMID:18256700)
(PMID:15752368), (PMID:18256700), (PMID:22365146)
ARUK-UCL PMID:15752368, PMID:18256700, PMID:22365146 MGI:MGI:6294189 NCBI chr20:24,889,834...24,900,766
Ensembl chr20:25,237,251...25,248,364
JBrowse link
G CSTA cystatin A ISO (PMID:6203523) BHF-UCL PMID:6203523 NCBI chr 3:119,417,489...119,432,244
Ensembl chr 3:126,323,901...126,338,430
JBrowse link
G CSTB cystatin B ISO (PMID:6203523) BHF-UCL PMID:6203523 NCBI chr21:30,030,359...30,032,899 JBrowse link
G ECM1 extracellular matrix protein 1 ISO (PMID:16512877) UniProtKB PMID:16512877 NCBI chr 1:125,853,337...125,858,904
Ensembl chr 1:129,502,041...129,507,819
JBrowse link
G SERPINB4 serpin family B member 4 ISO (PMID:12949073) UniProtKB PMID:12949073 NCBI chr18:56,996,437...57,003,489 JBrowse link
G SERPINE2 serpin family E member 2 ISO (MGI:MGI:3521551|PMID:15509762), (MGI:MGI:3810206|PMID:18398001) MGI PMID:15509762, PMID:18398001 MGI:MGI:3521551, MGI:MGI:3810206 NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040
JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 ISO (MGI:MGI:72783|PMID:3428272) MGI PMID:3428272 MGI:MGI:72783 NCBI chr 5:143,273,137...143,287,745 JBrowse link
negative regulation of plasminogen activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPB2 carboxypeptidase B2 ISO RGD PMID:23369837 RGD:7243115 NCBI chr13:26,926,788...26,979,767 JBrowse link
G CTSZ cathepsin Z ISO (PMID:19433310) CAFA PMID:19433310 NCBI chr20:55,346,241...55,358,354
Ensembl chr20:56,706,511...56,718,941
JBrowse link
G SERPINE1 serpin family E member 1 ISO (PMID:8508955)
(MGI:MGI:4418017|PMID:19855083)
(PMID:18835034), (PMID:19855083)
BHF-UCL PMID:8508955, PMID:18835034, PMID:19855083 MGI:MGI:4418017 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G SERPINE2 serpin family E member 2 ISO (MGI:MGI:4418017|PMID:19855083)
(PMID:19855083)
BHF-UCL PMID:19855083 MGI:MGI:4418017 NCBI chr2B:111,221,317...111,285,491
Ensembl chr2B:229,797,655...229,861,040
JBrowse link
G SERPINF2 serpin family F member 2 ISO (PMID:134998) BHF-UCL PMID:134998 NCBI chr17:1,725,469...1,738,887
Ensembl chr17:1,618,549...1,631,570
JBrowse link
G THBS1 thrombospondin 1 ISO (PMID:6438154) BHF-UCL PMID:6438154 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170
JBrowse link
negative regulation of proteasomal protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALAD aminolevulinate dehydratase ISO (PMID:8175643) CAFA PMID:8175643 NCBI chr 9:84,488,339...84,503,360
Ensembl chr 9:112,859,171...112,873,784
JBrowse link
G F8A1 coagulation factor VIII associated 1 ISO (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:144,366,123...144,367,842 JBrowse link
G F8A2 coagulation factor VIII associated 2 ISO (PMID:27815841) UniProt PMID:27815841 NCBI chr  X:144,851,466...144,853,185 JBrowse link
G GABARAPL2 GABA type A receptor associated protein like 2 ISO (PMID:21669198) BHF-UCL PMID:21669198 NCBI chr16:56,135,482...56,147,046
Ensembl chr16:75,483,459...75,495,019
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO (MGI:MGI:6148636|PMID:17517623) ARUK-UCL PMID:17517623 MGI:MGI:6148636, RGD:13514081 NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872
JBrowse link
G LAMP3 lysosomal associated membrane protein 3 ISO (PMID:25681212) ParkinsonsUK-UCL PMID:25681212 NCBI chr 3:180,152,363...180,193,223
Ensembl chr 3:188,324,660...188,363,268
JBrowse link
G LOC100988585 transmembrane protein 220 ISO (MGI:MGI:5643882|PMID:25683716) MGI PMID:25683716 MGI:MGI:5643882 NCBI chr17:40,923,397...40,973,382
Ensembl chr17:45,703,642...45,720,520
Ensembl chr17:45,703,642...45,720,520
JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 ISO (PMID:29295817) UniProtKB PMID:29295817 NCBI chr2B:47,004,211...47,059,901
Ensembl chr2B:164,377,605...164,432,907
JBrowse link
G OPHN1 oligophrenin 1 ISO (MGI:MGI:5303043|PMID:21874017) UniProtKB PMID:21874017 MGI:MGI:5303043 NCBI chr  X:57,288,297...57,674,685
Ensembl chr  X:67,359,364...67,739,114
JBrowse link
G PRKCG protein kinase C gamma ISO (MGI:MGI:5467682|PMID:23185022) UniProtKB PMID:23185022 MGI:MGI:5467682 NCBI chr19:50,823,372...50,849,003
Ensembl chr19:59,672,097...59,695,977
JBrowse link
G PSME3IP1 proteasome activator subunit 3 interacting protein 1 ISO (PMID:29934401) UniProt PMID:29934401 NCBI chr16:37,430,698...37,464,089
Ensembl chr16:56,563,353...56,596,619
JBrowse link
G PSMF1 proteasome inhibitor subunit 1 ISO (PMID:10764772) UniProtKB PMID:10764772 NCBI chr20:1,275,662...1,325,410
Ensembl chr20:1,043,513...1,092,237
JBrowse link
G USP19 ubiquitin specific peptidase 19 ISO (MGI:MGI:5614537|PMID:25088257) ParkinsonsUK-UCL PMID:25088257 MGI:MGI:5614537 NCBI chr 3:49,032,373...49,045,238
Ensembl chr 3:50,100,216...50,125,112
JBrowse link
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAG5 BAG cochaperone 5 ISO (PMID:24475098) ParkinsonsUK-UCL PMID:24475098 NCBI chr14:84,182,879...84,189,180
Ensembl chr14:103,997,524...103,998,927
JBrowse link
G BAG6 BAG cochaperone 6 ISO (MGI:MGI:3808636|PMID:18678708) UniProtKB PMID:18678708 MGI:MGI:3808636 NCBI chr 6:31,300,126...31,313,829
Ensembl chr 6:32,190,037...32,204,321
JBrowse link
G CAMLG calcium modulating ligand ISO (PMID:20553626) UniProt PMID:20553626 NCBI chr 5:130,138,644...130,144,540
Ensembl chr 5:136,282,910...136,295,382
JBrowse link
G CCAR2 cell cycle and apoptosis regulator 2 ISO (PMID:23398316) UniProtKB PMID:23398316 NCBI chr 8:21,854,803...21,870,556
Ensembl chr 8:18,794,027...18,808,571
JBrowse link
G CLEC16A C-type lectin domain containing 16A ISO (MGI:MGI:5603233|PMID:24949970) MGI PMID:24949970 MGI:MGI:5603233 NCBI chr16:9,887,877...10,124,500
Ensembl chr16:11,109,869...11,343,512
JBrowse link
G DDRGK1 DDRGK domain containing 1 ISO (PMID:28263186) UniProtKB PMID:28263186 NCBI chr20:3,276,292...3,290,433
Ensembl chr20:3,038,779...3,052,789
JBrowse link
G EIF3H eukaryotic translation initiation factor 3 subunit H ISO (PMID:32269044) FlyBase PMID:32269044 NCBI chr 8:113,320,059...113,440,769
Ensembl chr 8:115,863,490...115,973,872
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase ISO (PMID:15313915) UniProtKB PMID:15313915 NCBI chr 3:59,670,777...61,177,974 JBrowse link
G GIPC1 GIPC PDZ domain containing family member 1 ISO (MGI:MGI:3807767|PMID:11546783) BHF-UCL PMID:11546783 MGI:MGI:3807767 NCBI chr19:14,041,192...14,059,402
Ensembl chr19:14,885,185...14,889,701
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO (PMID:24613385)
(PMID:16280321)
UniProtKB
MGI
PMID:16280321, PMID:24613385 NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872
JBrowse link
G KLHL40 kelch like family member 40 ISO (MGI:MGI:5586592|PMID:24960163) MGI PMID:24960163 MGI:MGI:5586592 NCBI chr 3:42,592,977...42,600,100
Ensembl chr 3:43,657,128...43,664,055
JBrowse link
G MAP1A microtubule associated protein 1A ISO (MGI:MGI:5703671|PMID:26609151) ARUK-UCL PMID:26609151 MGI:MGI:5703671 NCBI chr15:22,472,641...22,493,293
Ensembl chr15:40,627,099...40,647,752
JBrowse link
G MTM1 myotubularin 1 ISO (MGI:MGI:5510937|PMID:23695157) MGI PMID:23695157 MGI:MGI:5510937 NCBI chr  X:140,218,742...140,323,495
Ensembl chr  X:150,174,758...150,255,381
JBrowse link
G N4BP1 NEDD4 binding protein 1 ISO (MGI:MGI:3829128|PMID:17592138) UniProtKB PMID:17592138 MGI:MGI:3829128 NCBI chr16:28,809,881...28,881,352
Ensembl chr16:47,698,353...47,769,755
JBrowse link
G NOP53 NOP53 ribosome biogenesis factor ISO (PMID:22522597) UniProtKB PMID:22522597 NCBI chr19:44,739,739...44,751,303 JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase ISO (PMID:26678539) UniProtKB PMID:26678539 NCBI chr  X:60,798,219...60,840,948
Ensembl chr  X:70,852,687...70,894,921
JBrowse link
G PANO1 proapoptotic nucleolar protein 1 ISO (PMID:22094112) UniProtKB PMID:22094112 NCBI chr11:814,040...816,633 JBrowse link
G PARK7 Parkinsonism associated deglycase ISO (PMID:17015834) ParkinsonsUK-UCL PMID:17015834 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G PBK PDZ binding kinase ISO (MGI:MGI:5293269|PMID:21715333) MGI PMID:21715333 MGI:MGI:5293269 NCBI chr 8:27,084,789...27,112,986
Ensembl chr 8:24,285,395...24,313,658
JBrowse link
G RPL11 ribosomal protein L11 ISO (MGI:MGI:5897550|PMID:21804542) UniProtKB PMID:21804542 MGI:MGI:5897550 NCBI chr 1:22,883,157...22,887,806
Ensembl chr 1:23,868,688...23,873,313
JBrowse link
G RYBP RING1 and YY1 binding protein ISO (PMID:27060496) UniProtKB PMID:27060496 NCBI chr 3:72,315,494...72,389,328
Ensembl chr 3:74,247,807...74,318,398
JBrowse link
G SDCBP syndecan binding protein ISO (PMID:25893292) UniProtKB PMID:25893292 NCBI chr 8:54,992,627...55,022,560
Ensembl chr 8:56,643,962...56,673,833
JBrowse link
G SENP1 SUMO specific peptidase 1 ISO (MGI:MGI:3818351|PMID:17981124) MGI PMID:17981124 MGI:MGI:3818351 NCBI chr12:40,624,200...40,689,837
Ensembl chr12:41,507,348...41,558,969
JBrowse link
G SHH sonic hedgehog signaling molecule ISO (MGI:MGI:3624046|PMID:16611981) MGI PMID:16611981 MGI:MGI:3624046 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651
JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 ISO (MGI:MGI:5310666|PMID:22285184) MGI PMID:22285184 MGI:MGI:5310666 NCBI chr 3:47,487,948...47,683,623
Ensembl chr 3:48,590,221...48,781,248
JBrowse link
G TAF9 TATA-box binding protein associated factor 9 ISO (PMID:11278372) BHF-UCL PMID:11278372 NCBI chr 5:44,630,503...44,635,760 JBrowse link
G TLK2 tousled like kinase 2 ISO (PMID:20016786) UniProtKB PMID:20016786 NCBI chr17:56,542,670...56,678,294
Ensembl chr17:61,689,998...61,830,394
JBrowse link
G TRIM39 tripartite motif containing 39 ISO (PMID:23213251) UniProt PMID:23213251 NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:MGI:6362140 NCBI chr11:113,364,559...113,368,586
Ensembl chr11:117,295,191...117,298,928
JBrowse link
G UBXN1 UBX domain protein 1 ISO (PMID:20351172) UniProtKB PMID:20351172 NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404
JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 ISO (PMID:23770237) UniProtKB PMID:23770237 NCBI chr 1:168,471,501...168,519,366
Ensembl chr 1:172,764,606...172,811,880
JBrowse link
G USP7 ubiquitin specific peptidase 7 ISO (PMID:26678539) UniProtKB PMID:26678539 NCBI chr16:7,825,332...7,895,095
Ensembl chr16:9,065,858...9,106,146
JBrowse link
G WAC WW domain containing adaptor with coiled-coil ISO (PMID:22354037) BHF-UCL PMID:22354037 NCBI chr10:28,685,294...28,777,176
Ensembl chr10:29,042,331...29,130,591
JBrowse link
negative regulation of protein deubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 ISO (PMID:15936278) BHF-UCL PMID:15936278 NCBI chr2B:106,536,846...106,544,430
Ensembl chr2B:225,127,967...225,135,556
JBrowse link
G TRIM21 tripartite motif containing 21 ISO (PMID:16472766) UniProtKB PMID:16472766 NCBI chr11:4,588,083...4,596,942
Ensembl chr11:4,254,152...4,262,981
JBrowse link
negative regulation of protein K48-linked deubiquitination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase ISO (PMID:21097510) ParkinsonsUK-UCL PMID:21097510 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G UBXN1 UBX domain protein 1 ISO (PMID:21135095) ParkinsonsUK-UCL PMID:21135095 NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404
JBrowse link
negative regulation of protein processing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP4 acid phosphatase 4 ISO (PMID:15219672) UniProtKB PMID:15219672 NCBI chr19:47,754,780...47,760,294
Ensembl chr19:56,649,018...56,653,909
JBrowse link
G CDH1 cadherin 1 ISO (MGI:MGI:3763814|PMID:17344476) MGI PMID:17344476 MGI:MGI:3763814 NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488
JBrowse link
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 ISO (PMID:22445366) UniProtKB PMID:22445366 NCBI chr15:19,895,554...19,898,672
Ensembl chr15:38,145,730...38,148,698
JBrowse link
G FMR1 FMRP translational regulator 1 ISO Casp3 RGD PMID:22817682 RGD:11566024 NCBI chr  X:136,937,889...136,976,828
Ensembl chr  X:147,365,748...147,405,321
JBrowse link
G GAS1 growth arrest specific 1 ISO (PMID:21357679) UniProtKB PMID:21357679 NCBI chr 9:58,079,700...58,082,849
Ensembl chr 9:86,139,009...86,140,045
JBrowse link
G GLG1 golgi glycoprotein 1 ISO (MGI:MGI:4829577|PMID:20530870) MGI PMID:20530870 MGI:MGI:4829577 NCBI chr16:55,014,892...55,172,877
Ensembl chr16:74,372,660...74,526,764
JBrowse link
G IL1R2 interleukin 1 receptor type 2 ISO (MGI:MGI:5468848|PMID:23395675) MGI PMID:23395675 MGI:MGI:5468848 Ensembl chr2A:103,042,328...103,078,190 JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO (PMID:21370995) ParkinsonsUK-UCL PMID:21370995 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462
JBrowse link
G MDM2 MDM2 proto-oncogene ISO caspase-3 RGD PMID:19638633 RGD:2317364 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278
JBrowse link
G NLRP7 NLR family pyrin domain containing 7 ISO (PMID:15817483) UniProtKB PMID:15817483 NCBI chr19:51,966,886...51,990,971
Ensembl chr19:60,662,184...60,677,844
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A ISO Casp3 RGD PMID:21925170 RGD:9999170 NCBI chr19:45,872,596...45,876,376
Ensembl chr19:54,880,141...54,883,003
JBrowse link
G SNX12 sorting nexin 12 ISO (PMID:22709416) UniProtKB PMID:22709416 NCBI chr  X:60,327,484...60,336,682
Ensembl chr  X:70,384,164...70,395,737
JBrowse link
G TMEM59 transmembrane protein 59 ISO (PMID:20427278) UniProtKB PMID:20427278 NCBI chr 1:53,305,154...53,326,975
Ensembl chr 1:54,899,026...54,920,478
JBrowse link
G TMEM98 transmembrane protein 98 ISO (MGI:MGI:6258499|PMID:30249802) UniProt PMID:30249802 MGI:MGI:6258499 NCBI chr17:23,844,747...23,858,390
Ensembl chr17:24,133,357...24,146,912
JBrowse link
negative regulation of protein processing involved in protein targeting to mitochondrion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SIRT4 sirtuin 4 ISO RGD PMID:24029877 RGD:9586053 NCBI chr12:117,867,453...117,887,968
Ensembl chr12:121,241,112...121,261,777
JBrowse link
negative regulation of proteolysis involved in cellular protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (MGI:MGI:5468878|PMID:23277542)
(PMID:25217637)
MGI
ParkinsonsUK-UCL
PMID:23277542, PMID:25217637 MGI:MGI:5468878 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G EFNA1 ephrin A1 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr 1:130,475,128...130,482,531
Ensembl chr 1:134,083,855...134,091,228
JBrowse link
G EPHA4 EPH receptor A4 ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790
JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STYX serine/threonine/tyrosine interacting protein ISO (PMID:28007894) UniProtKB PMID:28007894 NCBI chr14:33,326,587...33,371,399
Ensembl chr14:51,610,523...51,651,096
JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CR1 complement C3b/C4b receptor 1 (Knops blood group) ISO (PMID:6910481) UniProtKB PMID:6910481 NCBI chr 1:183,094,601...183,246,957 JBrowse link
G SERPINA1 serpin family A member 1 ISO RGD PMID:19240864 RGD:7411612 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419
JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 ISO (MGI:MGI:4442135|PMID:20110462)
(MGI:MGI:5428115|PMID:22228629)
RGD
MGI
PMID:12771515, PMID:20110462, PMID:22228629 MGI:MGI:4442135, MGI:MGI:5428115, RGD:724699 NCBI chr 5:143,273,137...143,287,745 JBrowse link
G SPINK2 serine peptidase inhibitor Kazal type 2 ISO (MGI:MGI:5287926|PMID:21705336) MGI PMID:21705336 MGI:MGI:5287926 NCBI chr 4:67,101,686...67,113,671 JBrowse link
G SPINK5 serine peptidase inhibitor Kazal type 5 ISO (MGI:MGI:3770082|PMID:17012259) UniProtKB PMID:17012259 MGI:MGI:3770082 NCBI chr 5:143,387,981...143,578,839
Ensembl chr 5:149,506,367...149,590,930
JBrowse link
G SPINK6 serine peptidase inhibitor Kazal type 6 ISO (MGI:MGI:5560845|PMID:24352040) MGI PMID:24352040 MGI:MGI:5560845 NCBI chr 5:143,631,560...143,644,177
Ensembl chr 5:149,639,882...149,652,448
JBrowse link
negative regulation of serine-type peptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPINK5 serine peptidase inhibitor Kazal type 5 ISO (MGI:MGI:4440399|PMID:20179351) MGI PMID:20179351 MGI:MGI:4440399 NCBI chr 5:143,387,981...143,578,839
Ensembl chr 5:149,506,367...149,590,930
JBrowse link
negative regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A ISO (MGI:MGI:4461099|PMID:20100865) MGI PMID:20100865 MGI:MGI:4461099 NCBI chr 6:34,450,695...34,653,881
Ensembl chr 6:35,548,124...35,776,185
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (MGI:MGI:5468878|PMID:23277542)
(PMID:16173922), (PMID:18560357)
MGI
CAFA
PMID:16173922, PMID:18560357, PMID:23277542 MGI:MGI:5468878 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr20:689,494...752,092
Ensembl chr20:456,629...521,126
JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 ISO (PMID:28031292) ARUK-UCL PMID:28031292 NCBI chr16:38,426,399...38,466,575
Ensembl chr16:57,557,270...57,596,218
JBrowse link
G HFE homeostatic iron regulator ISO (PMID:24904118) BHF-UCL PMID:24904118 NCBI chr 6:25,921,663...25,930,852
Ensembl chr 6:26,580,358...26,588,591
JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 ISO (PMID:21628596) FlyBase PMID:21628596 NCBI chr 7:131,506,711...131,722,943 JBrowse link
G PDCL3 phosducin like 3 ISO (PMID:23792958) MGI PMID:23792958
G PML PML nuclear body scaffold ISO (PMID:15195100) UniProtKB PMID:15195100 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
JBrowse link
G PSEN1 presenilin 1 ISO (MGI:MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:MGI:4887523 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876
JBrowse link
G PSEN2 presenilin 2 ISO (MGI:MGI:4887523|PMID:20208556) BHF-UCL PMID:20208556 MGI:MGI:4887523 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295
JBrowse link
G QRICH2 glutamine rich 2 ISO (PMID:30683861)
(MGI:MGI:6277293|PMID:30683861)
UniProt PMID:30683861 MGI:MGI:6277293 NCBI chr17:70,222,033...70,256,747
Ensembl chr17:75,774,651...75,807,651
JBrowse link
G RPL11 ribosomal protein L11 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 1:22,883,157...22,887,806
Ensembl chr 1:23,868,688...23,873,313
JBrowse link
G RPL23 ribosomal protein L23 ISO (PMID:15314173) CAFA PMID:15314173 NCBI chr17:18,417,964...18,421,708
Ensembl chr17:18,690,682...18,698,253
JBrowse link
G RPL5 ribosomal protein L5 ISO (PMID:18560357) CAFA PMID:18560357 NCBI chr 1:95,497,047...95,507,006
Ensembl chr 1:94,230,451...94,241,522
JBrowse link
G RPS7 ribosomal protein S7 ISO (PMID:17310983) CAFA PMID:17310983 NCBI chr2A:3,593,350...3,599,106 JBrowse link
G SGTA small glutamine rich tetratricopeptide repeat containing alpha ISO (PMID:23129660) UniProtKB PMID:23129660 NCBI chr19:1,778,728...1,808,199
Ensembl chr19:2,736,565...2,763,440
JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling ISO (MGI:MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:MGI:4355593 NCBI chr10:99,107,516...99,231,761
Ensembl chr10:102,571,886...102,696,472
JBrowse link
G TAF1 TATA-box binding protein associated factor 1 ISO (PMID:17237821) ParkinsonsUK-UCL PMID:17237821 NCBI chr  X:60,630,137...60,729,904
Ensembl chr  X:70,684,217...70,782,323
JBrowse link
G TRIM39 tripartite motif containing 39 ISO (PMID:19100260) BHF-UCL PMID:19100260 NCBI chr 6:30,104,381...30,121,649
Ensembl chr 6:30,975,260...30,995,764
JBrowse link
G WNT1 Wnt family member 1 ISO (MGI:MGI:3628833|PMID:16601693) MGI PMID:16601693 MGI:MGI:3628833 NCBI chr12:39,767,839...39,772,460
Ensembl chr12:40,648,413...40,652,583
JBrowse link
negative regulation of ubiquitin-specific protease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase ISO (PMID:21097510) ParkinsonsUK-UCL PMID:21097510 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
G UBXN1 UBX domain protein 1 ISO (PMID:21135095) ParkinsonsUK-UCL PMID:21135095 NCBI chr11:58,033,304...58,035,893
Ensembl chr11:61,386,797...61,389,404
JBrowse link
zymogen inhibition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme ISO (PMID:11799113), (PMID:9130696) UniProt PMID:9130696, PMID:11799113 NCBI chr15:69,560,774...69,576,007
Ensembl chr15:88,763,269...88,774,023
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    metabolic process 7979
      primary metabolic process 7070
        protein metabolic process 4039
          proteolysis 1110
            negative regulation of proteolysis 224
              negative regulation of membrane protein ectodomain proteolysis 4
              negative regulation of peptidase activity + 119
              negative regulation of protein desumoylation 0
              negative regulation of protein deubiquitination + 4
              negative regulation of protein processing + 30
              negative regulation of proteolysis involved in cellular protein catabolic process + 70
Path 2
Term Annotations click to browse term
  biological_process 12564
    metabolic process 7979
      organic substance metabolic process 7672
        macromolecule metabolic process 6628
          protein metabolic process 4039
            cellular protein metabolic process 3640
              regulation of cellular protein metabolic process 2244
                negative regulation of cellular protein metabolic process 864
                  negative regulation of proteolysis 224
                    negative regulation of membrane protein ectodomain proteolysis 4
                    negative regulation of peptidase activity + 119
                    negative regulation of protein desumoylation 0
                    negative regulation of protein deubiquitination + 4
                    negative regulation of protein processing + 30
                    negative regulation of proteolysis involved in cellular protein catabolic process + 70
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.