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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of smoothened signaling pathway
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Accession:GO:0045879 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
Synonyms:exact_synonym: down regulation of smoothened signaling pathway;   downregulation of smoothened signaling pathway;   negative regulation of hedgehog signaling pathway;   negative regulation of hh signaling pathway;   negative regulation of smoothened signalling pathway
 narrow_synonym: inhibition of smoothened signaling pathway;   negative regulation of smoothened by patched
 related_synonym: negative regulation of smoothened activity;   negative regulation of smoothened receptor activity by patched
 alt_id: GO:0045877


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negative regulation of smoothened signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd3e CD3e molecule JBrowse link 8 49,297,604 49,309,370 RGD:1624291
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:1624291
G Gas1 growth arrest-specific 1 JBrowse link 17 4,846,116 4,849,350 RGD:1624291
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:1624291
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1624291
G Glis2 GLIS family zinc finger 2 JBrowse link 10 11,154,459 11,177,063 RGD:1624291
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:1600115
RGD:1624291
G Gpr37l1 G protein-coupled receptor 37-like 1 JBrowse link 13 51,985,698 51,992,547 RGD:1624291
RGD:1600115
G Herc4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 JBrowse link 20 26,755,948 26,831,267 RGD:1624291
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:1624291
G Ift122 intraflagellar transport 122 JBrowse link 4 147,756,574 147,826,983 RGD:1624291
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:1624291
G Kctd11 potassium channel tetramerization domain containing 11 JBrowse link 10 56,489,552 56,491,715 RGD:1624291
G Kctd21 potassium channel tetramerization domain containing 21 JBrowse link 1 162,307,746 162,325,284 RGD:1624291
RGD:1600115
G Kctd6 potassium channel tetramerization domain containing 6 JBrowse link 15 18,484,607 18,493,188 RGD:1624291
G Kif7 kinesin family member 7 JBrowse link 1 141,434,183 141,452,592 RGD:1624291
G Megf8 multiple EGF-like-domains 8 JBrowse link 1 82,184,671 82,234,045 RGD:1600115
RGD:1624291
G Mgrn1 mahogunin ring finger 1 JBrowse link 10 10,832,573 10,881,999 RGD:1600115
RGD:1624291
G Mosmo modulator of smoothened JBrowse link 1 190,604,613 190,671,906 RGD:1624291
RGD:13792537
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:1624291
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:1624291
RGD:1600115
G Runx2 RUNX family transcription factor 2 JBrowse link 9 18,564,743 18,773,092 RGD:1624291
RGD:1600115
G Sall1 spalt-like transcription factor 1 JBrowse link 19 23,387,737 23,405,025 RGD:1624291
G Sall3 spalt-like transcription factor 3 JBrowse link 18 77,572,200 77,591,710 RGD:1624291
G Serpine2 serpin family E member 2 JBrowse link 9 85,560,852 85,629,410 RGD:1624291
RGD:1600115
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
G Tulp3 TUB like protein 3 JBrowse link 4 161,636,084 161,677,807 RGD:1624291
G Ulk3 unc-51 like kinase 3 JBrowse link 8 62,368,548 62,375,229 RGD:1624291
RGD:1600115
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1600115
RGD:1624291
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1624291
negative regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 JBrowse link 1 21,748,201 21,813,205 RGD:1600115
RGD:1624291
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpr161 G protein-coupled receptor 161 JBrowse link 13 83,530,389 83,576,117 RGD:1624291
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:1624291
RGD:1600115
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:1624291
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:1624291
G Traf3ip1 TRAF3 interacting protein 1 JBrowse link 9 98,621,499 98,658,223 RGD:1624291
G Tulp3 TUB like protein 3 JBrowse link 4 161,636,084 161,677,807 RGD:1624291
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift122 intraflagellar transport 122 JBrowse link 4 147,756,574 147,826,983 RGD:1624291
G Rfx4 regulatory factor X4 JBrowse link 7 25,831,358 25,909,976 RGD:1624291
RGD:13792537
G Rfx8 RFX family member 8, lacking RFX DNA binding domain JBrowse link 9 46,414,407 46,476,076 RGD:13792537
G Tulp3 TUB like protein 3 JBrowse link 4 161,636,084 161,677,807 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19404
    cellular process 18142
      signal transduction 6884
        negative regulation of signal transduction 1221
          negative regulation of smoothened signaling pathway 37
            negative regulation of hh target transcription factor activity 1
            negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 6
            negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 4
Path 2
Term Annotations click to browse term
  biological_process 19404
    biological regulation 13421
      regulation of biological process 12724
        regulation of cellular process 12223
          signal transduction 6884
            cell surface receptor signaling pathway 2689
              smoothened signaling pathway 157
                regulation of smoothened signaling pathway 93
                  negative regulation of smoothened signaling pathway 37
                    negative regulation of hh target transcription factor activity 1
                    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning 6
                    negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.