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ONTOLOGY REPORT - ANNOTATIONS


Term:nucleobase biosynthetic process
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Accession:GO:0046112 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.
Synonyms:exact_synonym: nucleobase anabolism;   nucleobase biosynthesis;   nucleobase formation;   nucleobase synthesis


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'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase IDA
IBA
ISO
PMID:21873635
(PMID:24332717)
RGD PMID:24332717, PMID:1476792, PMID:21873635 RGD:5132591, RGD:13792537 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:133,759,722...133,786,452
Ensembl chr 5:133,759,735...133,786,452
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:1476792, PMID:21873635 RGD:5132591, RGD:13792537 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO (MGI:MGI:5469988|PMID:23429704) RGD PMID:23429704 MGI:MGI:5469988 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Umps uridine monophosphate synthetase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
adenine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyl transferase ISO
IBA
MGI:MGI:2429961 (MGI:MGI:85816|PMID:8864750)
PMID:21873635
RGD PMID:8864750, PMID:21873635 MGI:MGI:85816, RGD:13792537 NCBI chr19:55,387,288...55,389,256
Ensembl chr19:55,387,288...55,389,256
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO
IBA
MGI:MGI:1857299 (MGI:MGI:1331314|PMID:10037486)
PMID:21873635
RGD PMID:10037486, PMID:21873635 MGI:MGI:1331314, RGD:13792537 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:158,623,231...158,655,277
Ensembl chr  X:158,623,240...158,655,198
JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO
IBA
ISS
MGI:MGI:1857299 (MGI:MGI:1331314|PMID:10037486)
PMID:21873635
GO_REF:0000024
(PMID:19527031)
RGD
UniProt
PMID:10037486, PMID:19527031, PMID:21873635 GO_REF:0000024, MGI:MGI:1331314, RGD:13792537 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr  X:158,623,231...158,655,277
Ensembl chr  X:158,623,240...158,655,198
JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 NOT ISO (PMID:21054786) RGD PMID:21054786 NCBI chr17:87,926,242...88,037,040
Ensembl chr17:87,927,058...88,037,040
JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3640719|PMID:10720488) RGD PMID:10720488 MGI:MGI:3640719 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 ISO (PMID:17701896) RGD PMID:17701896 NCBI chr  X:111,798,233...111,820,270
Ensembl chr  X:111,798,233...111,820,266
JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO
ISS
(PMID:19527031)
GO_REF:0000024
RGD
UniProt
PMID:19527031 GO_REF:0000024 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G LOC103689983 hypoxanthine-guanine phosphoribosyltransferase ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:158,623,231...158,655,277
Ensembl chr  X:158,623,240...158,655,198
JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppat phosphoribosyl pyrophosphate amidotransferase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:33,580,541...33,614,919
Ensembl chr14:33,580,541...33,614,919
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IBA
(PMID:11516159)
PMID:21873635
RGD PMID:11516159, PMID:21873635 RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctps1 CTP synthase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:139,475,934...139,505,065
Ensembl chr 5:139,475,934...139,505,065
JBrowse link
G Ctps2 CTP synthase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:33,383,087...33,522,852
Ensembl chr  X:33,383,087...33,522,836
JBrowse link
G Umps uridine monophosphate synthetase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628
JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO MGI:MGI:1857117|MGI:MGI:2683027 (MGI:MGI:3640719|PMID:10720488) RGD PMID:10720488 MGI:MGI:3640719 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        organonitrogen compound metabolic process 7132
          nucleobase metabolic process 49
            nucleobase biosynthetic process 18
              purine nucleobase biosynthetic process + 10
              pyrimidine nucleobase biosynthetic process + 8
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cellular metabolic process 11065
        cellular nitrogen compound metabolic process 6683
          nucleobase-containing compound metabolic process 5483
            nucleobase-containing small molecule metabolic process 590
              nucleobase metabolic process 49
                nucleobase biosynthetic process 18
                  purine nucleobase biosynthetic process + 10
                  pyrimidine nucleobase biosynthetic process + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.