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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin catabolic process
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Accession:GO:0046223 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin breakdown;   aflatoxin catabolism;   aflatoxin degradation


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aflatoxin catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 IMP RGD PMID:12727802 RGD:1304380 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 ISO MGI:MGI:4430389 (MGI:MGI:4429761|PMID:19850059) RGD PMID:19850059 MGI:MGI:4429761 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 IMP RGD PMID:27071940 RGD:12910550 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    detoxification 137
      toxin catabolic process 3
        mycotoxin catabolic process 3
          aflatoxin catabolic process 3
Path 2
Term Annotations click to browse term
  biological_process 20014
    response to stimulus 10568
      response to chemical 6330
        response to toxic substance 306
          detoxification 137
            toxin catabolic process 3
              mycotoxin catabolic process 3
                aflatoxin catabolic process 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.