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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin catabolic process
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Accession:GO:0046223 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin breakdown;   aflatoxin catabolism;   aflatoxin degradation


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aflatoxin catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC474938 glutathione S-transferase A2 ISO (MGI:MGI:4429761|PMID:19850059) MGI PMID:19850059 MGI:MGI:4429761 NCBI chr12:20,349,133...20,365,023 JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 ISO RGD PMID:27071940 RGD:12910550 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    detoxification 101
      toxin catabolic process 2
        mycotoxin catabolic process 2
          aflatoxin catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 16162
    response to stimulus 8537
      response to chemical 5053
        response to toxic substance 259
          detoxification 101
            toxin catabolic process 2
              mycotoxin catabolic process 2
                aflatoxin catabolic process 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.