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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin catabolic process
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Accession:GO:0046223 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin breakdown;   aflatoxin catabolism;   aflatoxin degradation


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aflatoxin catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR7A3 aldo-keto reductase family 7 member A3 IEA Ensembl GO_REF:0000107 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 ISO (MGI:MGI:4429761|PMID:19850059) MGI PMID:19850059 MGI:MGI:4429761 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18626
    detoxification 144
      toxin catabolic process 3
        mycotoxin catabolic process 3
          aflatoxin catabolic process 3
Path 2
Term Annotations click to browse term
  biological_process 18626
    response to stimulus 10122
      response to chemical 5615
        response to toxic substance 318
          detoxification 144
            toxin catabolic process 3
              mycotoxin catabolic process 3
                aflatoxin catabolic process 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.