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ONTOLOGY REPORT - ANNOTATIONS


Term:aflatoxin catabolic process
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Accession:GO:0046223 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.
Synonyms:exact_synonym: aflatoxin breakdown;   aflatoxin catabolism;   aflatoxin degradation


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aflatoxin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr7a3 aldo-keto reductase family 7 member A3 JBrowse link 5 157,801,120 157,813,756 RGD:1304380
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:12910550

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    detoxification 136
      toxin catabolic process 3
        mycotoxin catabolic process 3
          aflatoxin catabolic process 3
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      response to chemical 6305
        response to toxic substance 303
          detoxification 136
            toxin catabolic process 3
              mycotoxin catabolic process 3
                aflatoxin catabolic process 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.