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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of JNK cascade
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Accession:GO:0046329 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
Synonyms:exact_synonym: down regulation of JNK cascade;   downregulation of JNK cascade
 narrow_synonym: inhibition of JNK cascade


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negative regulation of JNK cascade term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO UniProtKB:O35625 (MGI:3799599|PMID:17681137) RGD PMID:17681137 MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:17064355 RGD:2298577 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 ISO (MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:3693042 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISS
ISO
IEA
GO_REF:0000024
(MGI:6162308|PMID:29291351)
(PMID:29291351)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:29291351 GO_REF:0000024, GO_REF:0000107, MGI:6162308 NCBI chr19:19,264,984...19,323,817
Ensembl chr19:19,265,164...19,315,357
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 ISO
IBA
(PMID:17197390)
(MGI:5437437|PMID:17197390)
PMID:21873635
RGD PMID:17197390, PMID:21873635 MGI:5437437, RGD:13792537 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
(PMID:10391943)
MGI:3052343 (MGI:3051749|PMID:15306813)
PMID:21873635
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Dusp3 dual specificity phosphatase 3 ISO
IBA
(PMID:11085983), (PMID:19010898)
PMID:21873635
RGD PMID:11085983, PMID:19010898, PMID:21873635 RGD:13792537 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G F2rl1 F2R like trypsin receptor 1 ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Fktn fukutin ISO (PMID:18808525) RGD PMID:18808525 NCBI chr 5:70,522,001...70,578,270
Ensembl chr 5:70,528,688...70,578,273
JBrowse link
G Gps2 G protein pathway suppressor 2 ISO (PMID:11931768)
(MGI:6148454|PMID:22424771)
RGD PMID:11931768, PMID:22424771 MGI:6148454 NCBI chr10:56,524,327...56,527,447
Ensembl chr10:56,524,468...56,526,987
JBrowse link
G Hdac3 histone deacetylase 3 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO (MGI:3774677|PMID:18246070) RGD PMID:18246070 MGI:3774677 NCBI chr 3:150,660,665...150,752,016
Ensembl chr 3:150,686,638...150,749,827
JBrowse link
G Klhl31 kelch-like family member 31 ISO (PMID:18719355) RGD PMID:18719355 NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Marveld3 MARVEL domain containing 3 ISO (PMID:24567356) RGD PMID:24567356 NCBI chr19:41,710,076...41,724,923
Ensembl chr19:41,710,102...41,724,923
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO (PMID:10856240) RGD PMID:10856240 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
JBrowse link
G Men1 menin 1 ISO (PMID:12226747) RGD PMID:12226747 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 IEA
ISO
GO_REF:0000107
(PMID:11931768)
Ensembl
RGD
PMID:11931768 GO_REF:0000107 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO MGI:1100089 (MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:5308511 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Per1 period circadian regulator 1 IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 IDA RGD PMID:18567805 RGD:4107045 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 IMP PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr18:36,371,041...36,471,020
Ensembl chr18:36,371,041...36,471,015
JBrowse link
G Sirpa signal-regulatory protein alpha IEA
ISO
GO_REF:0000107
(MGI:3760575|PMID:17954568)
Ensembl
RGD
PMID:17954568 GO_REF:0000107, MGI:3760575 NCBI chr 3:122,113,735...122,152,478
Ensembl chr 3:122,114,108...122,152,477
JBrowse link
G Taok3 TAO kinase 3 ISO
IEA
(PMID:10559204)
GO_REF:0000107
RGD
Ensembl
PMID:10559204 GO_REF:0000107 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:63,825,616...63,914,740
Ensembl chr17:63,825,627...63,879,171
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated ISO (PMID:17681137)
(MGI:3799599|PMID:17681137)
RGD PMID:17681137 MGI:3799599 NCBI chr13:101,698,096...101,724,928
Ensembl chr13:101,698,096...101,724,923
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 ISO
ISS
(PMID:24512202)
GO_REF:0000024
RGD
UniProt
PMID:24512202 GO_REF:0000024 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO
IBA
(PMID:10391943)
MGI:3052343 (MGI:3051749|PMID:15306813)
PMID:21873635
RGD PMID:10391943, PMID:15306813, PMID:21873635 MGI:3051749, RGD:13792537 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS
(PMID:16636664)
(MGI:3721484|PMID:12646564), (MGI:5009198|PMID:10945608), (MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:10945608, PMID:12646564, PMID:16023107, PMID:16636664 GO_REF:0000024, MGI:3721484, MGI:5009198, MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 IEA
ISO
GO_REF:0000107
(MGI:1913166|PMID:11034606)
Ensembl
RGD
PMID:11034606 GO_REF:0000107, MGI:1913166 NCBI chr 3:94,349,778...94,419,185
Ensembl chr 3:94,352,969...94,419,048
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP PMID:21076496 RGD
UniProt
PMID:12064607, PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Nppa natriuretic peptide A ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pdcd4 programmed cell death 4 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:206,342,066...206,390,348
Ensembl chr 2:206,342,066...206,390,348
JBrowse link
G Serpinb3 serpin family B member 3 ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 IEA
ISO
GO_REF:0000107
MGI:108078|MGI:1860298 (MGI:3839161|PMID:19300477)
Ensembl
RGD
PMID:19300477 GO_REF:0000107, MGI:3839161 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:1860298|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 ISO MGI:108078|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 1:261,442,108...261,446,570
Ensembl chr 1:261,442,108...261,446,570
JBrowse link
G Tp73 tumor protein p73 ISO (MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:3574697 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      signal transduction 7010
        intracellular signal transduction 2593
          MAPK cascade 831
            stress-activated MAPK cascade 248
              JNK cascade 181
                negative regulation of JNK cascade 38
                  negative regulation of JUN kinase activity 15
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            intracellular signal transduction 2593
              MAPK cascade 831
                regulation of MAPK cascade 756
                  regulation of stress-activated MAPK cascade 190
                    negative regulation of stress-activated MAPK cascade 50
                      negative regulation of JNK cascade 38
                        negative regulation of JUN kinase activity 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.