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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of JNK cascade
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Accession:GO:0046330 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
Synonyms:exact_synonym: up regulation of JNK cascade;   upregulation of JNK cascade
 narrow_synonym: activation of JNK cascade;   stimulation of JNK cascade


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positive regulation of JNK cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGER advanced glycosylation end-product specific receptor JBrowse link 12 1,574,251 1,577,410 RGD:9068941
G ANKRD6 ankyrin repeat domain 6 JBrowse link 12 48,646,173 48,844,231 RGD:13508589
G APP amyloid beta precursor protein JBrowse link 31 21,351,207 21,614,466 RGD:13508589
G AXIN1 axin 1 JBrowse link 6 40,155,797 40,218,330 RGD:9068941
G CARD9 caspase recruitment domain family member 9 JBrowse link 9 49,110,913 49,120,758 RGD:13508589
G CCL19 C-C motif chemokine ligand 19 JBrowse link 11 51,357,706 51,359,207 RGD:13508589
G CCL21 C-C motif chemokine ligand 21 JBrowse link 11 51,375,107 51,375,790 RGD:9068941
G CCN2 cellular communication network factor 2 JBrowse link 1 25,508,082 25,511,058 RGD:13508589
G CD27 CD27 molecule JBrowse link 27 38,534,704 38,537,806 RGD:13508589
G CDC42 cell division cycle 42 JBrowse link 2 77,153,276 77,169,947 RGD:9068941
G CEACAM1 CEA cell adhesion molecule 1 JBrowse link 1 111,902,429 111,919,191 RGD:9068941
G DAB2IP DAB2 interacting protein JBrowse link 9 60,725,887 60,918,242 RGD:9068941
G DIXDC1 DIX domain containing 1 JBrowse link 5 21,097,000 21,168,470 RGD:9068941
G DUSP19 dual specificity phosphatase 19 JBrowse link 36 26,095,436 26,111,700 RGD:9068941
G DUSP22 dual specificity phosphatase 22 JBrowse link 35 678,320 733,225 RGD:13508589
G EDAR ectodysplasin A receptor JBrowse link 10 34,873,311 34,943,140 RGD:13508589
G F2RL1 F2R like trypsin receptor 1 JBrowse link 3 29,801,119 29,810,006 RGD:13508589
G FGF19 fibroblast growth factor 19 JBrowse link 18 48,464,931 48,469,967 RGD:13508589
G FLT4 fms related receptor tyrosine kinase 4 JBrowse link 11 1,145,643 1,184,097 RGD:13508589
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 6 77,393,026 77,396,473 RGD:13508589
G GADD45B growth arrest and DNA damage inducible beta JBrowse link 20 56,627,915 56,629,960 RGD:13508589
G GADD45G growth arrest and DNA damage inducible gamma JBrowse link 1 96,745,001 96,746,535 RGD:13508589
G HIPK2 homeodomain interacting protein kinase 2 JBrowse link 16 9,066,957 9,256,916 RGD:13508589
G HMGB1 high mobility group box 1 JBrowse link 25 9,431,223 9,558,167 RGD:13508589
G HRAS HRas proto-oncogene, GTPase JBrowse link 18 25,642,844 25,644,717 RGD:13508589
G IL1A interleukin 1 alpha JBrowse link 17 36,969,581 36,979,445 RGD:9068941
G IL1B interleukin 1 beta JBrowse link 17 37,019,329 37,033,388 RGD:9068941
G IL3 interleukin 3 JBrowse link 11 20,330,480 20,332,668 RGD:9068941
G LOC100856270 low affinity immunoglobulin gamma Fc region receptor II JBrowse link 38 20,980,777 20,994,403 RGD:9068941
G LTBR lymphotoxin beta receptor JBrowse link 27 38,598,725 38,605,829 RGD:13508589
G MAP2K7 mitogen-activated protein kinase kinase 7 JBrowse link 20 52,594,450 52,604,236 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 1 113,422,239 113,435,979 RGD:9068941
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 18 51,593,641 51,609,245 RGD:9068941
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 29,107,813 29,306,437 RGD:9068941
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 12 49,669,849 49,740,039 RGD:9068941
G MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 JBrowse link 18 52,353,606 52,367,065 RGD:9068941
G MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 10 41,088,020 41,276,801 RGD:9068941
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 JBrowse link 18 43,517,186 43,522,603 RGD:9068941
G MFHAS1 malignant fibrous histiocytoma amplified sequence 1 JBrowse link 16 35,579,531 35,676,552 RGD:13508589
G MINK1 misshapen like kinase 1 JBrowse link 5 31,707,975 31,718,013 RGD:13508589
G MMP8 matrix metallopeptidase 8 JBrowse link 5 29,036,381 29,047,180 RGD:13508589
G MTURN maturin, neural progenitor differentiation regulator homolog JBrowse link 14 42,890,343 42,928,985 RGD:9068941
G MYD88 MYD88 innate immune signal transduction adaptor JBrowse link 23 7,901,578 7,905,274 RGD:13508589
G NCF1 neutrophil cytosolic factor 1 JBrowse link 6 5,702,222 5,719,515 RGD:13508589
G NOD1 nucleotide binding oligomerization domain containing 1 JBrowse link 14 43,162,671 43,226,948 RGD:13508589
G NOD2 nucleotide binding oligomerization domain containing 2 JBrowse link 2 64,636,850 64,667,232 RGD:13508589
G NOX1 NADPH oxidase 1 JBrowse link X 74,784,627 74,811,796 RGD:13508589
G PJA2 praja ring finger ubiquitin ligase 2 JBrowse link 3 2,689,238 2,797,142 RGD:13508589
G PLCB1 phospholipase C beta 1 JBrowse link 24 13,337,285 13,996,218 RGD:9068941
G PTK2B protein tyrosine kinase 2 beta JBrowse link 25 30,137,546 30,264,221 RGD:13508589
G PYCARD PYD and CARD domain containing JBrowse link 6 17,049,352 17,051,348 RGD:13508589
G RASGRP1 RAS guanyl releasing protein 1 JBrowse link 30 5,840,901 5,914,804 RGD:13508589
G RASSF2 Ras association domain family member 2 JBrowse link 24 16,736,786 16,779,910 RGD:9068941
G RB1CC1 RB1 inducible coiled-coil 1 JBrowse link 29 4,445,668 4,544,223 RGD:13508589
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 35 3,367,796 3,407,631 RGD:9068941
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 29 35,283,209 35,311,608 RGD:9068941
G SERPINF2 serpin family F member 2 JBrowse link 9 45,876,076 45,883,777 RGD:13508589
G SH3RF1 SH3 domain containing ring finger 1 JBrowse link 25 20,025,920 20,208,470 RGD:9068941
G SH3RF2 SH3 domain containing ring finger 2 JBrowse link 2 40,380,313 40,514,211 RGD:13508589
G SH3RF3 SH3 domain containing ring finger 3 JBrowse link 10 34,374,376 34,730,548 RGD:13508589
G SLAMF1 signaling lymphocytic activation molecule family member 1 JBrowse link 38 21,653,801 21,685,408 RGD:9068941
G STK3 serine/threonine kinase 3 JBrowse link 13 647,363 920,887 RGD:13508589
G TAOK1 TAO kinase 1 JBrowse link 9 43,501,752 43,660,077 RGD:9068941
G TAOK2 TAO kinase 2 JBrowse link 6 18,014,685 18,029,188 RGD:13508589
G TAOK3 TAO kinase 3 JBrowse link 26 14,534,083 14,712,779 RGD:9068941
G TIRAP TIR domain containing adaptor protein JBrowse link 5 8,222,217 8,237,595 RGD:9068941
G TLR3 toll like receptor 3 JBrowse link 16 44,617,012 44,633,591 RGD:9068941
G TLR4 toll like receptor 4 JBrowse link 11 71,356,390 71,367,166 RGD:13508589
G TNF tumor necrosis factor JBrowse link 12 1,074,561 1,076,425 RGD:9068941
G TNFRSF19 TNF receptor superfamily member 19 JBrowse link 25 14,985,893 15,075,701 RGD:13508589
G TNFSF11 TNF superfamily member 11 JBrowse link 22 8,226,931 8,257,926 RGD:9068941
G TPD52L1 TPD52 like 1 JBrowse link 1 64,165,833 64,216,851 RGD:9068941
G TRAF1 TNF receptor associated factor 1 JBrowse link 11 73,920,729 73,939,644 RGD:13508589
G TRAF3 TNF receptor associated factor 3 JBrowse link 8 70,739,389 70,794,448 RGD:13508589
G TRAF4 TNF receptor associated factor 4 JBrowse link 9 42,933,638 42,940,033 RGD:13508589
G TRAF5 TNF receptor associated factor 5 JBrowse link 7 9,812,019 9,831,955 RGD:13508589
G TRAF6 TNF receptor associated factor 6 JBrowse link 18 31,674,242 31,689,160 RGD:13508589
G TRPV4 transient receptor potential cation channel subfamily V member 4 JBrowse link 26 17,293,334 17,330,156 RGD:9068941
G UNC5CL unc-5 family C-terminal like JBrowse link 12 9,782,411 9,794,822 RGD:13508589
G WNT16 Wnt family member 16 JBrowse link 14 59,388,034 59,404,812 RGD:13508589
G WNT5A Wnt family member 5A JBrowse link 20 34,756,430 34,790,937 RGD:9068941
G WNT7A Wnt family member 7A JBrowse link 20 4,072,010 4,139,521 RGD:13508589
G WNT7B Wnt family member 7B JBrowse link 10 20,160,916 20,208,786 RGD:13508589
G ZNF622 zinc finger protein 622 JBrowse link 4 86,929,947 86,943,711 RGD:9068941
activation of JNKK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ERCC6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 28 1,358,383 1,432,276 RGD:13508589
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,918,210 43,996,817 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 1 113,422,239 113,435,979 RGD:13508589
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 18 51,593,641 51,609,245 RGD:13508589
G MAP3K12 mitogen-activated protein kinase kinase kinase 12 JBrowse link 27 1,721,484 1,736,204 RGD:13508589
G MAP3K13 mitogen-activated protein kinase kinase kinase 13 JBrowse link 34 18,081,158 18,252,800 RGD:13508589
G MAP3K9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 8 44,435,714 44,509,528 RGD:13508589
G MAPKBP1 mitogen-activated protein kinase binding protein 1 JBrowse link 30 8,807,584 8,857,693 RGD:9068941
G NRK Nik related kinase JBrowse link X 79,341,449 79,488,046 RGD:13508589
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 35 3,367,796 3,407,631 RGD:13508589
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 29 35,283,209 35,311,608 RGD:13508589
G TNIK TRAF2 and NCK interacting kinase JBrowse link 34 35,426,716 35,727,308 RGD:9068941
activation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCL19 C-C motif chemokine ligand 19 JBrowse link 11 51,357,706 51,359,207 RGD:9068941
G CD40LG CD40 ligand JBrowse link X 107,001,421 107,023,007 RGD:13508589
G DAB2IP DAB2 interacting protein JBrowse link 9 60,725,887 60,918,242 RGD:9068941
G ERCC6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 28 1,358,383 1,432,276 RGD:13508589
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 9 11,930,614 12,006,724 RGD:13508589
G ERN2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 6 22,150,275 22,165,382 RGD:13508589
G FCER1A Fc fragment of IgE receptor Ia JBrowse link 38 22,683,478 22,688,842 RGD:9068941
G FGD4 FYVE, RhoGEF and PH domain containing 4 JBrowse link 27 16,252,405 16,464,099 RGD:9068941
G GAB1 GRB2 associated binding protein 1 JBrowse link 19 10,269 117,808 RGD:9068941
G INS insulin JBrowse link 18 46,324,047 46,324,933 RGD:9068941
G LOC477072 serotransferrin JBrowse link 23 30,658,250 30,683,816 RGD:9068941
G MAP2K4 mitogen-activated protein kinase kinase 4 JBrowse link 5 36,142,610 36,243,673 RGD:13508589
G MAP2K7 mitogen-activated protein kinase kinase 7 JBrowse link 20 52,594,450 52,604,236 RGD:13508589
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,918,210 43,996,817 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 1 113,422,239 113,435,979 RGD:13508589
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 18 51,593,641 51,609,245 RGD:13508589
G MAP3K12 mitogen-activated protein kinase kinase kinase 12 JBrowse link 27 1,721,484 1,736,204 RGD:13508589
G MAP3K13 mitogen-activated protein kinase kinase kinase 13 JBrowse link 34 18,081,158 18,252,800 RGD:13508589
G MAP3K20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 36 17,353,829 17,515,247 RGD:9068941
G MAP3K9 mitogen-activated protein kinase kinase kinase 9 JBrowse link 8 44,435,714 44,509,528 RGD:13508589
G MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 JBrowse link 1 114,444,231 114,461,254 RGD:13508589
G MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 JBrowse link 18 52,353,606 52,367,065 RGD:13508589
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 6 39,132,746 39,179,427 RGD:13508589
G MDFI MyoD family inhibitor JBrowse link 12 10,324,499 10,339,699 RGD:9068941
G MDFIC MyoD family inhibitor domain containing JBrowse link 14 54,063,832 54,153,346 RGD:9068941
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 2 78,394,013 78,402,032 RGD:13508589
G PTPN1 protein tyrosine phosphatase non-receptor type 1 JBrowse link 24 36,936,469 37,010,929 RGD:13508589
G RIPK1 receptor interacting serine/threonine kinase 1 JBrowse link 35 3,367,796 3,407,631 RGD:13508589
G RIPK2 receptor interacting serine/threonine kinase 2 JBrowse link 29 35,283,209 35,311,608 RGD:13508589
G SPAG9 sperm associated antigen 9 JBrowse link 9 26,820,381 26,966,315 RGD:13508589
G SYK spleen associated tyrosine kinase JBrowse link 1 95,903,501 95,955,577 RGD:9068941
G TNFSF11 TNF superfamily member 11 JBrowse link 22 8,226,931 8,257,926 RGD:13508589
G WNT5A Wnt family member 5A JBrowse link 20 34,756,430 34,790,937 RGD:13508589
G WNT7B Wnt family member 7B JBrowse link 10 20,160,916 20,208,786 RGD:9068941
positive regulation of JUN kinase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGER advanced glycosylation end-product specific receptor JBrowse link 12 1,574,251 1,577,410 RGD:13508589
G ARHGEF5 Rho guanine nucleotide exchange factor 5 JBrowse link 16 5,648,947 5,673,488 RGD:13508589
G AXIN1 axin 1 JBrowse link 6 40,155,797 40,218,330 RGD:9068941
G DAB2IP DAB2 interacting protein JBrowse link 9 60,725,887 60,918,242 RGD:9068941
G DKK1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 26 35,697,428 35,701,596 RGD:13508589
G DUSP19 dual specificity phosphatase 19 JBrowse link 36 26,095,436 26,111,700 RGD:9068941
G DVL2 dishevelled segment polarity protein 2 JBrowse link 5 32,194,326 32,201,922 RGD:13508589
G DVL3 dishevelled segment polarity protein 3 JBrowse link 34 17,053,534 17,069,965 RGD:13508589
G EDN1 endothelin 1 JBrowse link 35 11,808,892 11,815,383 RGD:13508589
G EPHA4 EPH receptor A4 JBrowse link 37 27,670,143 27,809,642 RGD:13508589
G FGD2 FYVE, RhoGEF and PH domain containing 2 JBrowse link 12 6,069,251 6,091,972 RGD:13508589
G FZD10 frizzled class receptor 10 JBrowse link 26 1,907,382 1,909,416 RGD:13508589
G FZD4 frizzled class receptor 4 JBrowse link 21 12,699,886 12,709,132 RGD:9068941
G FZD5 frizzled class receptor 5 JBrowse link 37 16,123,788 16,126,634 RGD:13508589
G FZD8 frizzled class receptor 8 JBrowse link 2 1,319,179 1,322,103 RGD:13508589
G IL1B interleukin 1 beta JBrowse link 17 37,019,329 37,033,388 RGD:9068941
G IL1RN interleukin 1 receptor antagonist JBrowse link 17 37,236,690 37,250,424 RGD:9068941
G IRAK1 interleukin 1 receptor associated kinase 1 JBrowse link X 121,853,340 121,862,582 RGD:9068941
G MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 JBrowse link 17 62,055,705 62,290,808 RGD:9068941
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,918,210 43,996,817 RGD:9068941
G MAP3K10 mitogen-activated protein kinase kinase kinase 10 JBrowse link 1 113,422,239 113,435,979 RGD:9068941
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 JBrowse link 18 51,593,641 51,609,245 RGD:9068941
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 JBrowse link 1 49,590,615 49,702,289 RGD:9068941
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 29,107,813 29,306,437 RGD:13508589
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 12 49,669,849 49,740,039 RGD:13508589
G MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 JBrowse link 6 39,132,746 39,179,427 RGD:9068941
G PAK1 p21 (RAC1) activated kinase 1 JBrowse link 21 21,341,530 21,409,535 RGD:13508589
G PTK2B protein tyrosine kinase 2 beta JBrowse link 25 30,137,546 30,264,221 RGD:9068941
G ROR2 receptor tyrosine kinase like orphan receptor 2 JBrowse link 1 95,209,122 95,280,956 RGD:9068941
G RPS3 ribosomal protein S3 JBrowse link 21 23,180,515 23,187,034 RGD:9068941
G SASH1 SAM and SH3 domain containing 1 JBrowse link 1 39,221,243 39,478,057 RGD:13508589
G TAOK3 TAO kinase 3 JBrowse link 26 14,534,083 14,712,779 RGD:13508589
G TIAM1 TIAM Rac1 associated GEF 1 JBrowse link 31 26,058,858 26,440,059 RGD:9068941
G TLR6 toll like receptor 6 JBrowse link 3 73,504,357 73,523,964 RGD:13508589
G TLR9 toll like receptor 9 JBrowse link 20 37,529,322 37,547,117 RGD:9068941
G TNF tumor necrosis factor JBrowse link 12 1,074,561 1,076,425 RGD:13508589
G TNFRSF11A TNF receptor superfamily member 11a JBrowse link 1 14,504,595 14,555,956 RGD:13508589
G TRAF2 TNF receptor associated factor 2 JBrowse link 9 48,688,071 48,713,936 RGD:13508589
G TRAF6 TNF receptor associated factor 6 JBrowse link 18 31,674,242 31,689,160 RGD:13508589
G WNT5A Wnt family member 5A JBrowse link 20 34,756,430 34,790,937 RGD:9068941
G ZEB2 zinc finger E-box binding homeobox 2 JBrowse link 19 46,419,812 46,541,888 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16042
    cellular process 15297
      signal transduction 5381
        signal transduction by protein phosphorylation 795
          MAPK cascade 786
            stress-activated MAPK cascade 255
              JNK cascade 193
                positive regulation of JNK cascade 135
                  positive regulation of JUN kinase activity + 72
Path 2
Term Annotations click to browse term
  biological_process 16042
    metabolic process 10497
      organic substance metabolic process 9994
        macromolecule metabolic process 8684
          protein metabolic process 5321
            protein modification process 3688
              cellular protein modification process 3688
                protein phosphorylation 1875
                  signal transduction by protein phosphorylation 795
                    MAPK cascade 786
                      regulation of MAPK cascade 722
                        regulation of stress-activated MAPK cascade 229
                          positive regulation of stress-activated MAPK cascade 168
                            positive regulation of JNK cascade 135
                              positive regulation of JUN kinase activity + 72
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.