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ONTOLOGY REPORT - ANNOTATIONS


Term:icosanoid biosynthetic process
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Accession:GO:0046456 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids.
Synonyms:exact_synonym: eicosanoid biosynthesis;   eicosanoid biosynthetic process;   icosanoid anabolism;   icosanoid biosynthesis;   icosanoid formation;   icosanoid synthesis
 xref: Wikipedia:Eicosanoid


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icosanoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:5509794
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:14402444
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 JBrowse link 1 263,778,510 263,803,166 RGD:14402444
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:1624291
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:1625451
RGD:13792537
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:1625451
RGD:13792537
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:1625451
RGD:13792537
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 JBrowse link 5 133,978,953 134,008,255 RGD:13792537
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1624291
cyclooxygenase pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:1624291
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:1624291
RGD:1600115
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1600115
RGD:1624291
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:2311353
leukotriene A4 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1624291
RGD:1600115
leukotriene biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:632194
RGD:1624291
RGD:1600115
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:69749
RGD:13792537
RGD:1624291
RGD:2313889
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:1624291
G Lta4h leukotriene A4 hydrolase JBrowse link 7 34,288,333 34,320,243 RGD:1600115
RGD:13792537
RGD:1624291
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:724432
RGD:13792537
RGD:2302289
G Mgst2 microsomal glutathione S-transferase 2 JBrowse link 2 140,708,396 140,727,381 RGD:1624291
RGD:13792537
G Mgst3 microsomal glutathione S-transferase 3 JBrowse link 13 85,601,499 85,622,392 RGD:1624291
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:1624291
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1624291
RGD:1600115
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:2303037
RGD:1624291
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 JBrowse link 3 72,395,194 72,401,254 RGD:1624291
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:1624291
RGD:1600115
leukotriene D4 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07044631.2 RGD:13792537
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:1624291
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:1624291
RGD:13792537
lipoxin A4 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:1624291
RGD:1600115
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:1600115
RGD:1624291
lipoxin B4 biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:1624291
RGD:1600115
lipoxin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:1600115
RGD:1624291
negative regulation of prostaglandin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pibf1 progesterone immunomodulatory binding factor 1 JBrowse link 15 83,494,110 83,663,202 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
positive regulation of prostaglandin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:2306959
RGD:13792537
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:2300349
G Avpr1a arginine vasopressin receptor 1A JBrowse link 7 67,341,366 67,345,290 RGD:2300349
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:2304243
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1624291
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1642461
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1624291
prostaglandin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07034131.1 RGD:13792537
G AABR07054614.1 RGD:1600115
RGD:13792537
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
RGD:1600115
G Daglb diacylglycerol lipase, beta JBrowse link 12 13,113,073 13,157,748 RGD:1600115
RGD:1624291
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:1624291
G Edn2 endothelin 2 JBrowse link 5 139,098,472 139,106,396 RGD:1624291
RGD:1600115
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:68838
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:1624291
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:1624291
RGD:1600115
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:1624291
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 6 64,224,870 64,288,465 RGD:1624291
G Prxl2b peroxiredoxin like 2B JBrowse link 5 172,304,799 172,307,402 RGD:1624291
RGD:8552775
RGD:1600115
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:8553429
RGD:1624291
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:67929
RGD:13792537
RGD:1624291
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:5688071
RGD:13792537
RGD:1600115
RGD:1624291
G Ptges3l1 prostaglandin E synthase 3-like 1 JBrowse link X 45,410,545 45,419,817 RGD:13792537
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:727270
RGD:13792537
RGD:1624291
RGD:1600115
RGD:8693629
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:2300259
RGD:1600115
RGD:1624291
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:2300259
RGD:1624291
G Tbxas1 thromboxane A synthase 1 JBrowse link 4 66,624,181 66,846,745 RGD:1624291
regulation of prostaglandin biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      biosynthetic process 5984
        organic substance biosynthetic process 5887
          fatty acid derivative biosynthetic process 76
            icosanoid biosynthetic process 56
              leukotriene biosynthetic process + 15
              lipoxin biosynthetic process + 4
              prostanoid biosynthetic process + 32
Path 2
Term Annotations click to browse term
  biological_process 19676
    cellular process 18449
      cellular metabolic process 10780
        organic acid metabolic process 1067
          oxoacid metabolic process 1040
            carboxylic acid metabolic process 992
              carboxylic acid biosynthetic process 312
                icosanoid biosynthetic process 56
                  leukotriene biosynthetic process + 15
                  lipoxin biosynthetic process + 4
                  prostanoid biosynthetic process + 32
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.