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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylcholine metabolic process
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Accession:GO:0046470 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
Synonyms:exact_synonym: phosphatidylcholine metabolism


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phosphatidylcholine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd3 abhydrolase domain containing 3 JBrowse link 18 1,892,413 1,946,840 RGD:1624291
RGD:13792537
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:1624291
RGD:13792537
RGD:1600115
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:13792537
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 JBrowse link 17 42,085,027 42,131,344 RGD:1600115
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4889588
G Lcat lecithin cholesterol acyltransferase JBrowse link 19 37,913,333 37,916,799 RGD:1624291
RGD:1600115
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1600650
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:1624291
RGD:1600115
G Pla2g15 phospholipase A2, group XV JBrowse link 19 38,129,666 38,146,958 RGD:1582127
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:1624291
RGD:1600115
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:1624291
RGD:1600115
G Plaat1 phospholipase A and acyltransferase 1 JBrowse link 11 75,125,951 75,145,868 RGD:1624291
G Pnpla6 patatin-like phospholipase domain containing 6 JBrowse link 12 2,068,749 2,098,139 RGD:1600115
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:1624291
RGD:1600115
CDP-choline pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cept1 choline/ethanolamine phosphotransferase 1 JBrowse link 2 209,118,140 209,162,071 RGD:1600115
G Chka choline kinase alpha JBrowse link 1 219,076,618 219,126,221 RGD:1600115
G Chkb choline kinase beta JBrowse link 7 130,404,818 130,408,813 RGD:1600115
G Chpt1 choline phosphotransferase 1 JBrowse link 7 29,019,518 29,070,928 RGD:1600115
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha JBrowse link 11 71,547,865 71,592,037 RGD:8553740
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta JBrowse link X 62,727,691 62,821,199 RGD:1600115
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:1600115
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lpcat1 lysophosphatidylcholine acyltransferase 1 JBrowse link 1 32,379,431 32,429,917 RGD:1624291
RGD:1600115
negative regulation of phosphatidylcholine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
phosphatidylcholine acyl-chain remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dbi diazepam binding inhibitor, acyl-CoA binding protein JBrowse link 13 36,147,667 36,156,076 RGD:1624291
G Lpcat1 lysophosphatidylcholine acyltransferase 1 JBrowse link 1 32,379,431 32,429,917 RGD:1624291
RGD:1600115
G Lpcat2 lysophosphatidylcholine acyltransferase 2 JBrowse link 19 15,470,177 15,540,704 RGD:1600115
RGD:1624291
phosphatidylcholine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:1600115
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:1624291
RGD:1600115
G Cept1 choline/ethanolamine phosphotransferase 1 JBrowse link 2 209,118,140 209,162,071 RGD:1624291
G Chka choline kinase alpha JBrowse link 1 219,076,618 219,126,221 RGD:1624291
RGD:1600115
G Chkb choline kinase beta JBrowse link 7 130,404,818 130,408,813 RGD:1624291
G Chpt1 choline phosphotransferase 1 JBrowse link 7 29,019,518 29,070,928 RGD:1624291
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:1624291
G Fgf7 fibroblast growth factor 7 JBrowse link 3 118,315,859 118,368,464 RGD:68696
G Gpat4 glycerol-3-phosphate acyltransferase 4 JBrowse link 16 73,615,949 73,649,769 RGD:1624291
RGD:1600115
G Lcat lecithin cholesterol acyltransferase JBrowse link 19 37,913,333 37,916,799 RGD:1624291
RGD:1600115
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha JBrowse link 11 71,547,865 71,592,037 RGD:70012
RGD:1624291
RGD:729598
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:729486
RGD:13792537
RGD:1600115
G Phka1 phosphorylase kinase regulatory subunit alpha 1 JBrowse link X 72,377,020 72,515,385 RGD:724642
G Slc27a1 solute carrier family 27 member 1 JBrowse link 16 19,997,823 20,016,193 RGD:1600115
RGD:13792537
RGD:1624291
phosphatidylcholine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 JBrowse link 7 94,479,931 94,563,086 RGD:8553522
RGD:13792537
RGD:1624291
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 JBrowse link 1 198,199,032 198,209,178 RGD:1624291
RGD:1600115
G Pla2g15 phospholipase A2, group XV JBrowse link 19 38,129,666 38,146,958 RGD:1624291
RGD:1600115
G Pnpla8 patatin-like phospholipase domain containing 8 JBrowse link 6 64,224,870 64,288,465 RGD:1624291
RGD:1600115
positive regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acsl3 acyl-CoA synthetase long-chain family member 3 JBrowse link 9 84,569,601 84,593,565 RGD:1624291
RGD:1600115
G Capn2 calpain 2 JBrowse link 13 100,878,649 100,928,811 RGD:13792658
G Rab38 RAB38, member RAS oncogene family JBrowse link 1 152,072,716 152,153,449 RGD:13524861
regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fabp3 fatty acid binding protein 3 JBrowse link 5 148,528,854 148,535,597 RGD:1624291
RGD:1600115
regulation of phosphatidylcholine catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1624291
RGD:1600115
G Scarb1 scavenger receptor class B, member 1 JBrowse link 12 36,694,952 36,761,445 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17967
    metabolic process 10722
      nitrogen compound metabolic process 9148
        organonitrogen compound metabolic process 6372
          phosphatidylcholine metabolic process 41
            1,2-diacyl-sn-glycero-3-phosphocholine metabolic process 0
            phosphatidylcholine acyl-chain remodeling 3
            phosphatidylcholine biosynthetic process + 20
            phosphatidylcholine catabolic process + 7
            phosphatidylethanolamine acyl-chain remodeling 0
Path 2
Term Annotations click to browse term
  biological_process 17967
    metabolic process 10722
      primary metabolic process 9657
        lipid metabolic process 1261
          cellular lipid metabolic process 960
            glycerolipid metabolic process 341
              glycerophospholipid metabolic process 243
                phosphatidylcholine metabolic process 41
                  1,2-diacyl-sn-glycero-3-phosphocholine metabolic process 0
                  phosphatidylcholine acyl-chain remodeling 3
                  phosphatidylcholine biosynthetic process + 20
                  phosphatidylcholine catabolic process + 7
                  phosphatidylethanolamine acyl-chain remodeling 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.