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ONTOLOGY REPORT - ANNOTATIONS


Term:ceramide biosynthetic process
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Accession:GO:0046513 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.
Synonyms:exact_synonym: ceramide anabolism;   ceramide biosynthesis;   ceramide formation;   ceramide synthesis


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ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agk acylglycerol kinase JBrowse link 4 68,483,345 68,561,518 RGD:1624291
RGD:1600115
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:1600115
RGD:1624291
G Aloxe3 arachidonate lipoxygenase 3 JBrowse link 10 55,711,996 55,735,915 RGD:1624291
RGD:1600115
G Asah1 N-acylsphingosine amidohydrolase 1 JBrowse link 16 53,998,604 54,030,006 RGD:1600115
RGD:1624291
G Asah2 N-acylsphingosine amidohydrolase 2 JBrowse link 1 250,557,042 250,665,083 RGD:13838803
RGD:1624291
RGD:13838793
G Cers1 ceramide synthase 1 JBrowse link 16 20,845,580 20,860,789 RGD:1624291
G Cers2 ceramide synthase 2 JBrowse link 2 196,487,656 196,495,930 RGD:1624291
RGD:13792537
G Cers3 ceramide synthase 3 JBrowse link 1 127,706,618 127,781,041 RGD:1624291
RGD:13792537
G Cers4 ceramide synthase 4 JBrowse link 12 4,439,750 4,474,759 RGD:1624291
RGD:13792537
G Cers5 ceramide synthase 5 JBrowse link 7 141,386,391 141,424,375 RGD:1624291
RGD:13792537
G Cers6 ceramide synthase 6 JBrowse link 3 55,094,240 55,338,370 RGD:1624291
RGD:13792537
G Degs1 delta(4)-desaturase, sphingolipid 1 JBrowse link 13 100,665,265 100,672,731 RGD:1624291
RGD:13792537
G Degs2 delta(4)-desaturase, sphingolipid 2 JBrowse link 6 132,591,968 132,608,600 RGD:1624291
RGD:13792537
G Elovl1 ELOVL fatty acid elongase 1 JBrowse link 5 137,255,868 137,260,486 RGD:1600115
RGD:1624291
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
RGD:1600115
G LOC498300 similar to degenerative spermatocyte homolog JBrowse link 13 99,369,102 99,374,051 RGD:13792537
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:1624291
RGD:1600115
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G RGD1564463 similar to Mdes protein JBrowse link 13 99,374,006 99,395,804 RGD:13792537
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:13792537
G Sgms1 sphingomyelin synthase 1 JBrowse link 1 250,692,448 250,951,685 RGD:1624291
RGD:13792537
G Sgms2 sphingomyelin synthase 2 JBrowse link 2 236,458,276 236,530,667 RGD:1624291
RGD:13792537
RGD:1600115
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1601344
RGD:13792537
RGD:1624291
G Smpd2 sphingomyelin phosphodiesterase 2 JBrowse link 20 46,212,070 46,215,183 RGD:1581395
G Smpd4 sphingomyelin phosphodiesterase 4 JBrowse link 11 87,522,971 87,546,687 RGD:1624291
RGD:13792537
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 JBrowse link 17 11,856,525 11,895,566 RGD:1624291
RGD:1600115
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 JBrowse link 6 111,334,408 111,417,960 RGD:1624291
G Sptssa serine palmitoyltransferase, small subunit A JBrowse link 6 75,540,132 75,551,545 RGD:1624291
RGD:1600115
G Sptssb serine palmitoyltransferase, small subunit B JBrowse link 2 166,654,036 166,682,325 RGD:1624291
RGD:13792537
G Tlcd3b TLC domain containing 3B JBrowse link 1 198,252,208 198,265,840 RGD:1624291
RGD:1600115
galactosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B3galt1 Beta-1,3-galactosyltransferase 1 JBrowse link 3 53,699,409 54,269,612 RGD:1624291
RGD:1600115
G B3galt2 Beta-1,3-galactosyltransferase 2 JBrowse link 13 60,435,946 60,444,957 RGD:1624291
RGD:1600115
G B4galt3 beta-1,4-galactosyltransferase 3 JBrowse link 13 89,643,847 89,649,880 RGD:1624291
RGD:1600115
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:13825191
RGD:1624291
G Gal3st1 galactose-3-O-sulfotransferase 1 JBrowse link 14 84,231,473 84,247,371 RGD:1624291
RGD:1600115
G Ugt8 UDP glycosyltransferase 8 JBrowse link 2 229,644,373 229,718,678 RGD:1600115
ganglioside biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07013843.1 RGD:13792537
G B3galt4 Beta-1,3-galactosyltransferase 4 JBrowse link 20 5,446,104 5,447,679 RGD:1600115
RGD:1624291
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 JBrowse link 7 70,439,273 70,459,556 RGD:1624291
RGD:1600115
G St6galnac3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 JBrowse link 2 259,379,653 259,918,813 RGD:13792537
G St6galnac4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 JBrowse link 3 11,607,103 11,619,595 RGD:13792537
G St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 JBrowse link 2 258,025,177 259,150,709 RGD:13792537
G St6galnac6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 JBrowse link 3 11,620,050 11,641,460 RGD:1624291
RGD:13792537
G St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 JBrowse link 1 135,336,374 135,406,699 RGD:1624291
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 JBrowse link 18 59,748,766 59,755,257 RGD:1624291
RGD:1600115
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 JBrowse link 9 103,117,705 103,207,154 RGD:1624291
RGD:1600115
G St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 JBrowse link 17 80,960,785 81,002,830 RGD:1624291
ganglioside biosynthetic process via lactosylceramide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt5 beta-1,4-galactosyltransferase 5 JBrowse link 3 164,039,731 164,055,561 RGD:1600115
RGD:1624291
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:1600115
RGD:1624291
glucosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fa2h fatty acid 2-hydroxylase JBrowse link 19 43,545,380 43,596,788 RGD:1600115
RGD:1624291
G Ugcg UDP-glucose ceramide glucosyltransferase JBrowse link 5 76,376,722 76,419,564 RGD:13792537
RGD:1624291
RGD:1600115
lactosylceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt6 beta-1,4-galactosyltransferase 6 JBrowse link 18 15,462,913 15,525,584 RGD:1600115
RGD:1624291
negative regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 JBrowse link 9 53,110,628 53,120,454 RGD:1624291
RGD:13792537
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 JBrowse link 7 3,242,991 3,246,085 RGD:1624291
RGD:13792537
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 JBrowse link 10 86,545,910 86,554,478 RGD:1624291
RGD:13792537
RGD:1600115
G Sphk1 sphingosine kinase 1 JBrowse link 10 105,498,728 105,504,401 RGD:1600115
RGD:1624291
positive regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccn1 cellular communication network factor 1 JBrowse link 2 251,529,354 251,532,312 RGD:1624291
RGD:1600115
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6482750
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:1624291
G Smpd3 sphingomyelin phosphodiesterase 3 JBrowse link 19 38,237,963 38,321,572 RGD:10041064
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1600115
RGD:1624291
regulation of ceramide biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Samd8 sterile alpha motif domain containing 8 JBrowse link 15 2,685,504 2,731,062 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      cellular metabolic process 10461
        cellular nitrogen compound metabolic process 6216
          cellular amide metabolic process 1335
            amide biosynthetic process 1069
              ceramide biosynthetic process 60
                ganglioside biosynthetic process + 13
                glycosylceramide biosynthetic process + 7
                lactosylceramide biosynthetic process 1
                negative regulation of ceramide biosynthetic process + 4
                positive regulation of ceramide biosynthetic process + 6
                regulation of ceramide biosynthetic process + 11
Path 2
Term Annotations click to browse term
  biological_process 19245
    metabolic process 11438
      primary metabolic process 10300
        lipid metabolic process 1291
          cellular lipid metabolic process 979
            membrane lipid metabolic process 178
              sphingolipid metabolic process 130
                sphingolipid biosynthetic process 82
                  ceramide biosynthetic process 60
                    ganglioside biosynthetic process + 13
                    glycosylceramide biosynthetic process + 7
                    lactosylceramide biosynthetic process 1
                    negative regulation of ceramide biosynthetic process + 4
                    positive regulation of ceramide biosynthetic process + 6
                    regulation of ceramide biosynthetic process + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.